Biomechanical properties of cells play a very important role in regulating cells function. Experimental studies found that when Leukocytes move near the vessel wall, the phenomena such as rolling, jumping and adhesion will appear. Based on the non-linear fluid-structure interaction theory, leukocyte’s tiny jumping mechanism and rolling phenomenon were studied. The results were: 1) The choice of time step of leukocyte had a great influence on the movement of leukocyte. Instead of landing on the bottom of flow chamber, leukocyte jumped to a certain height and then moved periodically toward the bottom of the flow chamber again. Leukocyte had the biggest deformation when jumping; 2) Adhesion and rolling along the bottom of the flow chamber appeared in the process of moving forward, the scrolling speed was greater than that of pure rolling. Leukocytes’ movement in blood vessels was closely related with body physiological and pathological characteristics. The study of dynamic movement of leukocyte provided theoretical basis for clinical medicine.
Cite this paper
W. Li, "Numerical Simulation of Fluid-Structure Interaction Method on Dynamic Movement of Leukocyte in Flow Chamber," Advances in Pure Mathematics
, Vol. 3 No. 9, 2013, pp. 692-697. doi: 10.4236/apm.2013.39094
 M. Long, L. Harry, Goldsmith, D. F. J. Tees and C. Zhu, “Probabilistic Modeling of Shear-Induced Formation and Breakage of Doublets Cross-Linked by Receptor-Ligand Bonds,” Biophysical Journal, Vol. 76, No. 2, 1999, pp. 1112-1128. http://dx.doi.org/10.1016/S0006-3495(99)77276-0
 T. Yamaguchi, Y. Yamamoto and H. Liu, “Computational Mechanical Model Studies on the Spontaneous Emergent Morphogenesis of the Cultured Endothelial Cells,” Journal of Biomechanics, Vol. 33, No. 1, 2000, pp. 115-126. http://dx.doi.org/10.1016/S0021-9290(99)00159-1
 K. C. Chang, D. F. Tees and D. A. Hammer, “The State Diagram for Cell Adhesion under Flow: Leukocyte Rolling and Firm Adhesion,” Proceedings of the National Academy of Sciences, Vol. 97, No. 21, 2000, pp. 11262-11267. http://dx.doi.org/10.1073/pnas.200240897
 M. J. Slattery and C. Dong, “Neutrophils Influence Melanoma Adhesion and Migration under Flow Conditions,” International Journal of Cancer, Vol. 106, No. 5, 2003, pp. 713-722. http://dx.doi.org/10.1002/ijc.11297
 N. A. N’Dri, W. Shyy and R. Tran-Son-Tay, “Computational Modeling of Cell Adhesion and Movement Using a Continuum-Kinetics Approach,” Biophysics Journal, Vol. 84, No. 4, 2003, pp. 2273-2286.
 S. Liang, M. J. Slattery, D. Wagner, S. I. Simon and C. Dong, “Hydrodynamic Shear Rate Regulates Melanoma-Leukocyte Aggregation, Melanoma Adhesion to the Endothelium, and Subsequent Extravasation,” Annals of Biomedical Engineering, Vol. 36, No. 4, 2008, pp. 661-671. http://dx.doi.org/10.1007/s10439-008-9445-8
 A. Squeira, A. M. Artoli, A. S. Silva-Herdade and C. Saldanha, “Leukocytes Dynamics in Microcirculation under Shear-thinning Blood Flow,” Computers and Mathematics with Applications, Vol. 58, No. 5, 2009, pp. 1035-1044.http://dx.doi.org/10.1016/j.camwa.2009.02.003
 X. He, J. Cui, S. Wei and T. Yang, “Lattice Boltzmann Method with Immersed Boundary Method for Simulation RBC Movement in Micro-vessel,” Proceedings of the 8th World Congress on Intelligent Control and Automation, Jinan, 7-9 July 2010, pp. 1953-1958.