JCT  Vol.4 No.10 , December 2013
Inflammation and Carcinogenesis
ABSTRACT

We consider that inflammatory substances play an important role in the carcinogenesis process. In the process, cytokines and growth factor secreted by cells can actively recruit immune cells in the carcinogenesis microenvironment, further, promote carcinogenesis progression. The carcinogenesis microenvironment even subverted the immune system, moreover, enhanced the carcinogenesis through immune suppressive mechanisms within the carcinogenesis microenvironment.


Cite this paper
Y. Wu and S. Chen, "Inflammation and Carcinogenesis," Journal of Cancer Therapy, Vol. 4 No. 10, 2013, pp. 1449-1451. doi: 10.4236/jct.2013.410173.
References
[1]   P. Allavena, A. Sica, G. Solinas, et al., “The Inflammatory Micro-Environment in Tumor Progression: The Role of Tumor-Associated Macrophages,” Critical Reviews in Oncology/Hematology, Vol. 66, No. 1, 2008, pp. 1-9. http://dx.doi.org/10.1016/j.critrevonc.2007.07.004

[2]   N. A. Punchard, C. J. Whelan and I. Adcock, “The Journal of Inflammation,” Journal of Inflammation, Vol. 1, No. 1, 2004, p. 1. http://dx.doi.org/10.1186/1476-9255-1-1

[3]   D. Maslinska and M. Gajewski, “Some Aspects of the Inflammatory Process,” Folia Neuropathologica, Vol. 36, No. 4, 1998, pp. 199-204.

[4]   I. Sbarsi, C. Falcone, C. Boiocchi, et al., “Inflammation and Atherosclerosis: The role of TNF and TNF Receptors Polymorphisms in Coronary Artery Disease,” International Journal of Immunopathology and Pharmacology, Vol. 20, No. 1, 2007, pp. 145-154.

[5]   P. Libby, P. M. Ridker and A. Maseri, “Inflammation and Atherosclerosis,” Circulation, Vol. 105, No. 9, 2002, pp. 1135-1143. http://dx.doi.org/10.1161/hc0902.104353

[6]   J. M. Schott and T. Revesz, “Inflammation in Alzheime’s Disease: Insights from Immunotherapy,” Brain, Vol. 136, 2013, pp. 2654-2656. http://dx.doi.org/10.1093/brain/awt231

[7]   J. M. Rubio-Perez and J. M. Morillas-Ruiz, “A Review: Inflammatory Process in Alzheimer’s Disease, Role of Cytokines,” Scientific World Journal, Vol. 2012, 2012. Article ID: 756357 http://dx.doi.org/10. 1100/2012/756357

[8]   C. D. Gregory, “Inflammation and Cancer Revisited: An Hypothesis on the Oncogenic Potential of the Apoptotic Tumor Cell,” Autoimmunity, Vol. 46, No. 5, 2013, pp. 312-316. http://dx.doi.org/10. 3109/08916934.2012.755961

[9]   B. B. Aggarwal, S. Shishodia, S. K. Sandur et al., “Inflammation and cancer: How Hot Is the Link?” Biochemical Pharmacology, Vol. 72, No. 11, 2006, pp. 1605-1621.

[10]   G. S. Hotamisligil, N. S. Shargill and B. M. Spiegelman, “Adipose Expression of Tumor-Necrosis-Factor-Alpha-Direct Role in Obesity-Linked Insulin Resistance,” Science, Vol. 259, No. 5091, 1993, pp. 87-91. http://dx.doi.org/10.1126/science.7678183

[11]   J. L. Dunne, R. G. Collins, A. L. Beaudet, et al., “Mac-1, but Not LFA-1, Uses Intercellular Adhesion Molecule-1 to Mediate Slow Leukocyte Rolling in TNF-Alpha-Induced Inflammation,” Journal of Immunology, Vol. 171, No. 11, 2003, pp. 6105-6111.

[12]   C. V. Carman and T. A. Springer, “A Transmigratory Cup in Leukocyte Diapedesis Both through Individual Vascular Endothelial Cells and between Them,” Journal of Cell Biology, Vol. 167, No. 2, 2004, pp. 377-388. http://dx.doi.org/10.1083/jcb.200404129

[13]   S. K. Fried, D. A. Bunkin, and A. S. Greenberg, “Omental and Subcutaneous Adipose Tissues of Obese Subjects Release Interleukin-6: Depot Difference and Regulation by Glucocorticoid,” Journal of Clinical Endocrinology & Metabolism, vol. 83, No. 3, 1998, pp. 847-850. http://dx.doi.org/10.1210/jc.83.3.847

[14]   Z. Xing, J. Gauldie, G. Cox, et al., “IL-6 Is an Antiinflammatory Cytokine Required for Controlling Local or Systemic Acute Inflammatory Responses,” Journal of Clinical Investigation, Vol. 101, No. 2, 1998, pp. 311-320. http://dx.doi.org/10.1172/JCI1368

[15]   T. Sakurai, G. He, A. Matsuzawa, et al., “Hepatocyte Necrosis Induced by Oxidative Stress and IL-1 Alpha Release Mediate Carcinogen-Induced Compensatory Proliferation and Liver Tumorigenesis,” Cancer Cell, Vol. 14, No. 2, 2008, pp. 156-165. http://dx.doi.org/10.1016/j.ccr.2008.06.016

[16]   R. M. Gallucci, P. P. Simeonova, J. M. Matheson, et al., “Impaired Cutaneous Wound Healing in Interleukin-6-Deficient and Immunosuppressed Mice,” Faseb Journal, Vol. 14, No. 15, 2000, pp. 2525-2531. http://dx.doi.org/10.1096/fj.00-0073com

[17]   C. Gabay, C. Lamacchia and G. Palmer, “IL-1 Pathways in Inflammation and Human Diseases,” Nature Reviews Rheumatology, Vol. 6, No. 4, 2010, pp. 232-241. http://dx.doi.org/10.1038/ nrrheum.2010.4

[18]   C. A. Dinarello, “Biologic Basis for Interleukin-1 in Disease,” Blood, Vol. 87, No. 6, 1996, pp. 2095-2147.

[19]   G. E. Carpagnano, A. Spanevello, R. Sabato, et al., “Systemic and Airway Inflammation in Sleep Apnea and Obesity: The Role of ICAM-1 and IL-8,” Translational Research, Vol. 155, No. 1, 2010, pp. 35-43. http://dx.doi.org/10.1016/j.trsl.2009.09.004

[20]   M. Saraiva and A. O’Garra, “The Regulation of IL-10 Production by Immune Cells,” Nature Reviews Immunology, Vol. 10, No. 3, 2010, pp. 170-181. http://dx.doi.org/10.1038/nri2711

[21]   W. J. Ouyang, S. Rutz, N. K. Crellin, et al., “Regulation and Functions of the IL-10 Family of Cytokines in Inflammation and Disease,” Annual Review of Immunology, Vol 29, 2011, pp. 71-109.

[22]   F. Balkwill and A. Mantovani, “Inflammation and Cancer: Back to Virchow?” Lancet, Vol. 357, No. 9255, 2001, pp. 539-545. http://dx.doi.org/10.1016/S0140-6736(00)04046-0

[23]   E. Shacter and S. A. Weitzman, “Chronic Inflammation and Cancer,” Oncology-New York, Vol. 16, No. 2, 2002, p. 217.

[24]   S. I. Grivennikov, F. R. Greten and M. Karin, “Immunity, Inflammation, and Cancer,” Cell, Vol. 140, No. 6, 2010, pp. 883-899. http://dx.doi.org/10.1016/j.cell.2010.01.025

[25]   H. Clevers, “At the Crossroads of Inflammation and Cancer,” Cell, Vol. 118, No. 6, 2004, pp. 671-674. http://dx.doi.org/10.1016/j.cell.2004.09.005

[26]   E. Fosslien, “Molecular Pathology of Cyclooxygenase-2 in Neoplasia,” Annals of Clinical and Laboratory Science, Vol. 30, No. 1, 2000, pp. 3-21.

[27]   L. M. Coussens and Z. Werb, “Inflammation and Cancer,” Nature, Vol. 420, No. 6917, 2002, pp. 860-867.

 
 
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