Is it possible to block the cancer cells in circulating blood by extracorporeal circulation? Implications of the immune system and other factors (review)

Sante Basso  Ricci; Francesco  Garbagnati

doi:10.4236/oji.2013.34029

Sante Basso Ricci, Francesco Garbagnati^*

Abstract: The presence of cancer cells in circulating blood and the possibility of colonization in the tissues of the body worsen in a determinant way the prognosis of the disease. Nevertheless, there are factors in the body that can lead to a prognostic improvement, even in such conditions. In addition to the immune system, other favorable factors can act at the level of the microenvironment of the tumor so much that cases of spontaneous total regression, not only of primary tumors but also metastases, have been reported in the literature. Since it was recently reported that patients with renal tumors and in permanent hemodialysis present at post mortem examination, a metastatic spread much less extensive than observed in patients deceased for renal tumors but not on hemodialysis. The authors maintain it likely that the dialytic membrane concurs to block at least in part the cancer cells circulating in the blood. The possibility to block cancer cells can be extended in addition to the dialytic membrane also to other types of filters inserted in the extracorporeal circulation. The block of the cancer cells thus is obtained and that occurs in regional lymph nodes and in the microenvironment of the tumor causing a relative increase in the elements of the immune system compared to the number of cancer cells, which could determine clearly positive therapeutic results also in cases with advanced metastatic spread.

Keywords: Block of Cancer Cells; Extracorporeal Circulation; Filters; Immune System

Cite this paper: Ricci, S. and Garbagnati, F. (2013) Is it possible to block the cancer cells in circulating blood by extracorporeal circulation? Implications of the immune system and other factors (review). Open Journal of Immunology, 3, 224-227. doi: 10.4236/oji.2013.34029.

References

[1] Thoroddsen, A., Geirsson, G., Agnarson, B.A. and Magnusson, K. (2002) Spontaneous regression of pleural metastases after nephrectomy for renal cell carcinoma. Scandinavian Journal of Urology and Nephrology, 5, 396-398. http://dx.doi.org/10.1080/003655902320783971

[2] De Weerd, J.H., Hawthorn, J. and Adson, M.A. (1977) Regression of renal cell hepatic metastases following removal of primary lesions. Journal of Urology, 117, 790-792.

[3] Basso Ricci, S. and Cerchiari, U. (2010) Spontaneous regression of malignant tumors: importance of the immune system and other factors (review). Oncology Letters, 1, 941-945.

[4] Munshi, H.G. and Stack, M.S. (2006) Reciprocal interactions between adhesion receptor signaling and MMP regulation. Cancer Metastasis Review, 25, 45-56. http://dx.doi.org/10.1007/s10555-006-7888-7

[5] Hood, J.D. and Cheresh, D.A. (2002) Role of integrins in cell invasion and migration. National Review of Cancer, 2, 91-100. http://dx.doi.org/10.1038/nrc727

[6] Hoskin, D.H., Mader, J.S., Furlong, S.J., Conrad, D.M. and Blay, J. (2008) Inhibition of T cell and natural killer cell function by adenosine and its contribution to immune evasion by tumor cells (Review). International Journal of Oncology, 18, 527-535.

[7] Kurita, M., Hirano, K., Ebihara, S., Takushima, A., Hari, K., Fujino, T. and Fujioka, Y. (2007) Spontaneous regression of cervical lymph node metastasis in patients with nasopharyngeal squamous cell carcinoma of the tongue: Possible association between apoptosis and tumor regression. Journal of Clinical Oncology, 12, 448-454. http://dx.doi.org/10.1007/s10147-007-0711-9

[8] Basso Ricci, S. (2007) Dialysis membrane and metastatic cancer cells. Clinical Nephrology, 68, 354-356. http://dx.doi.org/10.5414/CNP68354

[9] Basso Ricci, S. and Cerchiari, U. (2009) Some relations among the dialysis membrane, metastatic cells and the immune system. Medical Hypotheses, 73, 328-331. http://dx.doi.org/10.1016/j.mehy.2009.03.043

[10] Basso Ricci, S. (2012) Therapeutic possibilities of techniques of extracorporeal blood circulation in oncology. Medical Hypotheses, 78, 1-3. http://dx.doi.org/10.1016/j.mehy.2011.09.026

[11] Witz, I.P. (2008) The selectin-selectin ligand axis in tumor progression. Cancer Metastasis Review, 27, 18-30. http://dx.doi.org/10.1007/s10555-007-9101-z

[12] Abercombe, M., Heasman, J. and Pegrum, S.M. (1975) The locomotion of fibroblasts in culture. Experimental Cell Research, 67, 359-367. http://dx.doi.org/10.1016/0014-4827(71)90420-4

[13] Abercombe, M. and Dunn, G.A. (1975) Adhesion fibroblasts to substratum during contact inhibition observed by interference reflection microscopy. Experimental Cell Research, 92, 57-62. http://dx.doi.org/10.1016/0014-4827(75)90636-9

[14] Lo, S.H. and Chen, L.B. (1994) Focal adhesion as a signal transduction organelle. Cancer Metastasis Review, 132, 9-24. http://dx.doi.org/10.1007/BF00690415

[15] Rousseau, Y., Haeffner Cavaillon, N., Poignet, J.L., Meyrier, A. and Carreno, M.P. (2000) In vitro intracellular cytokine production by leucocytes during hemodialysis. Cytokine, 12, 506-517. http://dx.doi.org/10.1006/cyto.1999.0574

[16] Bingel, M., Lonnemann, G., Koch, K.M., Dinarello, A. and Sheldon, S. (1988) Plasma interleukin-1 activity during hemodialysis: The influence of dialysis membrane. Nephron, 50, 273-276. http://dx.doi.org/10.1159/000185186

[17] Canivet, E., Lavand, S., Wong, T., Guenounoue, M., Willemin, J.C., Potron, G. and Chanard, J. (1994) Cuprophane but not synthetic membrane induces increases in serum tumor necrosis factor alpha levels during hemodialysis. American Journal of Kidney Disease, 23, 41-46.

[18] Arnaut M.A., Kakim R.M. and Todd R.F. (1985) Increased expression of an adhesion-promoting surface glycoprotein in the granulocytopenia of hemodialysis. New England Journal of Medicine, 312, 457-462. http://dx.doi.org/10.1056/NEJM198502213120801

[19] Dal Canton, A. (1993) Adhesion molecules in renal disease. Kidney International, 48, 1087-1090.

[20] Mrowka, C., Heintz, B. and Siebert, H.G. (1999) Is dialysis membrane type responsible for increased circulating adhesion molecules during chronic hemodialysis? Clinical Nephrology, 52, 312-321.