Mass deposition inside the artery wall may play a significant role in the development of the disease atherosclerosis. Locally elevated concentrations of LDL in the arterial wall are considered to be the initiator of atherosclerotic plaque formation. In this study, an attempt has been made to study initially the effect of fluid dynamic parameters on the disease and finally proposed a concept, from the idea of basic flow characteristics in constricted arteries, for the assessment of mass deposition in the arterial wall to some extent for rectangular as well as half circular stenosed models. Reynolds numbers are chosen as 100, 200, 300 and 400 and percentage of restrictions as 30%, 50%, 70% and 90% respectively. The governing Navier-Stokes and continuity equations are solved in the artery lumen with the commercial CFD code ANSYS 12.1. The pressure-velocity coupling equations are solved by SIMPLE (Semi-Implicit Method for Pressure-Linked Equations) algorithm. The studies on pressure drop at stenosis zone and flow separation zone reveal that the effect of percentage of restriction is more dominant than Reynolds number on the progression of the disease, atherosclerosis for any shaped restriction. The mass deposition results of rectangular and half circular stenotic models motivate to conclude that the effect of percentage of restriction is more prone to the disease than that of Reynolds number. Half circular stenotic shape insists for the less chance of mass deposition in the arterial wall compared to rectangular shaped restriction.
 Stangeby, D. and Ethier, C. (2002) Computational analysis of coupled blood-wall arterial LDL transport. ASME Journal of Biomechanical Engineering, 124, 1-8.
 Kaazempur-Mofrad, M., Wada, S., Myers, J. and Ethier, C. (2005) Mass transport and fluid flow in stenotic arteries: Axisymmetric and asymmetric models. International Journal of Heat and Mass Transfer, 48, 4510-4517.
 Sun, N.F., Torii, R., Wood, N.B., Hughes, A.D., Thom, S.A.M. and Xu, X.Y. (2006) Fluid-wall modelling of LDL transport in a human right coronary artery. Excerpt from the Proceedings of the COMSOL Users Conference, Birmingham.
 Valencia, A. and Villanueva, M. (2006) Unsteady flow and mass transfer in models of stenotic arteries considering fluid-structure interaction. International Communications in Heat and Mass Transfer, 33, 966-975.
 Gessaghia, V.C., Raschib, M.A., Larreteguym A.E. and Perazzo, C.A. (2007) Influence of arterial geometry on a model for growth rate of atheromas. Journal of Physics: Conference Series, 90, Article ID: 012046.
 Sun, N.F., Wood, N.B., Hughes, A.D., Thom, S.A.M. and Xu, X.Y. (2007) Influence of pulsatile flow on LDL transport in the arterial wall. Annals of Biomedical Engineering, 35, 1782-1790.
 Yang, N. and Vafai, K. (2008) Low-density lipoprotein (LDL) transport in an artery—A simplified analytical solution. International Journal of Heat and Mass Transfer, 51, 497-505.
 Yang, N. and Vafai, K. (2006) Modeling of low-density lipoprotein (LDL) transport in the artery—Effects of hypretension. International Journal of Heat and Mass Transfer, 49, 850-867.
 Olgac, U., Kurtcuoglu, V. and Poulikakos, D. (2008) Modeling of blood-wall low-density lipoprotein mass transport in dependence of shear stress. Journal of Biomechanics, 41, S277.
 Khakpour, M. and Vafai, K. (2008) Critical assessment of arterial transport models. International. Journal of Heat and Mass Transfer, 51, 807-822.
 Gessner, F.B. (1973) Haemodynamic theories of atehrogenesis. Circulation Research, 3, 259-266.
 Chesler, N.C. and Enyinna, O.C. (2003) Particle deposition in arteries ex vivo: Effects of pressure, flow and wave form. Journal of Biomechanical Engineering, 125, 389-394. http://dx.doi.org/10.1115/1.1572905
 Tu, C., Deville, M., Dheur, L. and Vanderschuren, L., (1992) Finite element simulation of pulsatile flow through arterial stenosis. Journal of Biomechanics, 25, 1141-1152.
 Weinbaum, S. and Chien, S., (1993) Lipid transport aspects of atherogenesis. Journal of Biomechanical Engineering, 115, 602-610.