The association of depression and perceived stress with beta cell function between African and Haitian Americans with and without type 2 diabetes

Fatma G.  Huffman; Maria  Vallasciani; Joan A.  Vaccaro; Joel C.  Exebio; Gustavo G.  Zarini; Ali  Nayer; Sahar  Ajabshir

doi:10.4236/jdm.2013.34036

JDM Vol.3 No.4 , November 2013

The association of depression and perceived stress with beta cell function between African and Haitian Americans with and without type 2 diabetes

Fatma G. Huffman, Maria Vallasciani, Joan A. Vaccaro, Joel C. Exebio, Gustavo G. Zarini, Ali Nayer, Sahar Ajabshir

Abstract: Background: Diabetes and diabetes-related complications are major causes of morbidity and mortality in the United States. Depressive symptoms and perceived stress have been identified as possible risk factors for beta cell dysfunction and diabetes. The purpose of this study was to assess associations between depression symptoms and perceived stress with beta cell function between African and Haitian Americans with and without type 2 diabetes. Participants and Methods: Informed consent and data were available for 462 participants (231 African Americans and 231 Haitian Americans) for this cross-sectional study. A demographic questionnaire developed by the Primary Investigator was used to collect information regarding age, gender, smoking, and ethnicity. Diabetes status was determined by self-report and confirmed by fasting blood glucose. Anthropometrics (weight, and height and waist circumference) and vital signs (blood pressure) were taken. Blood samples were drawn after 8 10 hours over-night fasting to measure lipid panel, fasting plasma glucose and serum insulin concentrations. The homeostatic model assessment, version 2 (HOMA2) computer model was used to calculate beta cell function. Depression was assessed using the Beck Depression Inventory-II (BDI-II) and stress levels were assessed using the Perceived Stress Scale (PSS). Results: Moderate to severe depressive symptoms were more likely for persons with diabetes (p = 0.030). There were no differences in perceived stress between ethnicity and diabetes status (p = 0.283). General linear models for participants with and without type 2 diabetes using beta cell function as the dependent variable showed no association with depressive symptoms and perceived stress; however, Haitian Americans had significantly lower beta cell function than African Americans both with and without diabetes and adjusting for age, gender, waist circumference and smoking. Further research is needed to compare these risk factors in other race/ethnic groups.

Keywords: Beta Cell Function; HOMA-IR2; Type 2 Diabetes; Haitian Americans; African Americans; Depressive Symptoms; Perceived Stress

Cite this paper: Huffman, F. , Vallasciani, M. , Vaccaro, J. , Exebio, J. , Zarini, G. , Nayer, A. and Ajabshir, S. (2013) The association of depression and perceived stress with beta cell function between African and Haitian Americans with and without type 2 diabetes. Journal of Diabetes Mellitus, 3, 236-243. doi: 10.4236/jdm.2013.34036.

References

[1] Center for Disease Control and Prevention (CDC) (2013) Age-specific percentage of civilian, non-institutionalized population with diagnosed diabetes, by age, race and sex, United States, Modified, March. http://www.cdc.gov/diabetes/statistics/prevalence_national.htm

[2] Cowie, C., Rust, K., Ford, E., Eberhardt, M., Bryd-Holt, D., Li, C., et al. (2009) Full accounting of diabetes and pre-diabetes in the U.S. population in 1988-1994 and 2005-2006. Diabetes Care, 32, 287-294. http://www.ncbi.nlm.nih.gov/pubmed/19017771 http://dx.doi.org/10.2337/dc08-1296

[3] Kahn, S.E. (2003) The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes. Diabetologia, 46, 3-19. http://www.ncbi.nlm.nih.gov/pubmed/ 12637977

[4] Beaudry, J. and Ridell, M. (2012) Effects of glucocorticoids and exercise on pancreatic B-cell function and diabetes development. Diabetes Metabolism Research and Reviews, 28, 560-573. http://www.yorku.ca/mriddell/documents/dmrr2310.pdf http://dx.doi.org/10.1002/ dmrr.2310

[5] Chung, J.-O., Cho, D.-H., Chung, D.-J. and Chung, M.-Y. (2012) Associations among body mass index, insulin resistance, and pancreatic B-cell function in Korean patients with new-onset type 2 diabetes. Korean Journal of International Medicine, 27, 66-71. http://www.ncbi.nlm.nih.gov/pmc/articles/ PMC3295991/ http://dx.doi.org/10.3904/kjim.2012.27.1.66

[6] Hasson, R., Adam, T., Pearson, J., Davis, J., Spruijt-Metz, D. and Goran, M. (2013) Sociocultural and socioeconomic influences on type 2 diabetes risk in overweight/ obese African American and Latino American children and adolescents. Journal of Obesity, Article ID: 512914. http://dx.doi.org/ 10.1155/2013/512914

[7] Pearson, S., Schmidt, M., Patton, G., Dwyer, T., Blizzard, L., Otahal, P. and Venn, A. (2010) Depression and insulin resistance. Diabetes Care, 33, 1128-1133. http://care.diabetesjournals. org/content/33/5/1128.long http://dx.doi.org/10.2337/dc09-1940

[8] Mezuk, B., Eaton, W., Albrecht, S. and Hill Golden, S. (2008) Depression and type 2 diabetes over the lifespan. Diabetes Care, 31, 2383-2390. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2584200/ http://dx.doi.org/10.2337/dc08-0985

[9] Timonen, M., Salmenkaita, I., Jokelainen, J., Laakso, M., Harkonen, P., Koskela, P., et al. (2007) Insulin resistance and depressive symptoms in young adult males: Findings from Finnish military conscripts. Psychosomatic Medicine, 69, 723-728. http://www.ncbi.nlm.nih.gov/pubmed/17942838 http://dx.doi.org/10.1097/PSY.0b013e318157ad2e

[10] Thomas, J., Jones, G., Scarinci, I. and Brantley, P. (2003) A descriptive and comparative study of the prevalence of depressive and anxiety disorders in low-income adults with type 2 diabetes and other chronic illnesses. Diabetes Care, 26, 2311-2317. http://www.ncbi.nlm.nih.gov/pubmed/12882854 http://dx.doi.org/10.2337/diacare.26.8.2311

[11] Engum, A., Mykletun, A., Midthjell, K., Holen, A. and Dahl, A. (2005) Depression and diabetes: A large population-based study of sociodemographic, lifestyle, and clinical factors associated with depression in type 1 and type 2 diabetes. Diabetes Care, 28, 1904-1909.
http://care.diabetesjournals.org/content/28/8/1904.full http://dx.doi.org/10.2337/diacare.28.8.1904

[12] Fisher, L., Mulan, J., Arean, P., Glasgow, R., Hessler, D. and Masharani, U. (2010) Diabetes depression but not clinical depression or depressive symptoms is associated with glycemic control in both cross-sectional and longitudinal analyses. Diabetes Care, 33, 23-28.
http://www.ncbi.nlm.nih.gov/pubmed/19837786 http://dx.doi.org/10.2337/dc09-1238

[13] American Diabetes Association (2013) Living with diabetes complications: African Americans and complications. http://www.diabetes.org/living-with-diabetes/complications/african-americans-and-complications.html

[14] Jackson, J., Knight, K. and Rafferty, J. (2010) Race and unhealthy behaviors: Chronic stress, the HPA axis, and physical and mental health disparities over the life course. American Journal of Public Health, 100, 933-939. http://www.ncbi.nlm.nih.gov/pubmed/19846689 http://dx.doi.org/10.2105/ AJPH.2008.143446

[15] Wallace, T.M., Levy, J.C. and Matthews, D.R. (2004) Use and abuse of HOMA modeling. Diabetes Care, 27, 1487-1495. http://www.ncbi.nlm.nih.gov/pubmed/15161807 http://dx.doi.org/10.2337/ diacare.27.6.1487

[16] Rudenski, A., Matthews, D., Levy, J. and Turner, R. (1991) Understanding insulin resistance: Both glucose resistance and insulin resistance are required to model human diabetes. Metabolism, 40, 908-917. http://www.ncbi.nlm.nih.gov/pubmed/1895955 http://dx.doi.org/10.1016/0026-0495 (91)90065-5

[17] Beck, A.T., Steer, R.A. and Brown, G.K. (1996) Manual for the Beck Depression Inventory-II. Psychological Corporation, San Antonio. http://www.nctsn.org/content/beck-depression-inventory-second-edition-bdi-ii

[18] Lustman, P.J., Clouse, R.E., Griffith, L.S., Carney, R.M. and Freedland, K.E. (1997) Screening for depression in diabetes using the Beck Depression inventory. Psychosomatic Medicine, 59, 24-31. http://www.ncbi.nlm.nih.gov/pubmed/9021863

[19] Cohen, S. and Williamson, G. (1988) Perceived stress in a probability sample of the United States. The Social Psychology of Health, 13, 31-67.

[20] Araya, R., Montero-Marin, J., Barroilhet, S., Fritsch, R. and Montgomery, A. (2013) Detecting depression among adolescents in Santiago, Chile: Sex differences. BMC Psychiatry, 13, 1-12. http://www.biomedcentral.com/1471-244X/13/122

[21] Lawlor, D., Ben-Shlomo, Y., Ebrahim, S., Smith, G., Stansfeld, S., Yarnell, J. and Gallacher, J. (2005) Insulin resistance and depressive symptoms in middle aged men: Findings from the Caerphilly prospective cohort study. BMJ, 330, 705-706. http://www.ncbi.nlm.nih.gov/pubmed/15684022 http://dx.doi.org/10.1136/bmj.38377.616921.F7

[22] Timonen, M., Laakso, M., Jokelainen, J., Rajala, U., Meyer-Rochow, V.B. and Keinanen-Kiukaanniemi, S. (2005) Insulin resistance and depression: Cross sectional study. BMJ, 330, 17-18. http://www.bmj.com/content/330/7481/17 http://dx.doi.org/10.1136/bmj.38313.513310.F71

[23] Pyykkonen, A., Raikkonen, K., Tuomi, T., Eriksson, J., de Groop, L. and Isomma, B. (2010) Stressful life events and the metabolic syndrome. Diabetes Care, 33, 378-384. http://www.ncbi.nlm.nih.gov/ pubmed/19880581 http://dx.doi.org/10.2337/dc09-1027

[24] Raikkonen K., Matthews, K. and Kuller, L. (2007) Depressive symptoms and stressful life events predict metabolic syndrome among middle-aged women. Diabetes Care, 30, 872-877. http://www.ncbi.nlm.nih.gov/pubmed/17392548 http://dx.doi.org/10.2337/dc06-1857

[25] Kim-Dorner, S., Simpson-Mackenzie, C., Poth, M. and Deuster, P. (2009) Psychological and physiological correlates of insulin resistance at fasting and in response to a meal in African Americans and Whites. Ethnicity & Disease, 10, 104-110. http://www.ncbi.nlm.nih.gov/pubmed/19537218

[26] Novak, M., Bjorck, L., Giang, K., Heden-Stahl, C., Wihelmsen, L. and Rosengren, A. (2013) Perceived stress and incidence of type 2 diabetes: A 35-year follow-up study of middle-aged Swedish men. Diabetic Medicine, 30, e8-e16. http://www.ncbi.nlm.nih.gov/pubmed/23075206

[27] Kruyt, N., van Westerloo D. and DeVries, H. (2012) Stress induced hyperglycemia in healthy bungee jumpers without diabetes due to decreased pancreatic B-cell function and increased insulin resistance. Diabetes Technology & Therapeutics, 14, 311-314.
http://www.ncbi.nlm.nih.gov/pubmed/22283617 http://dx.doi.org/10.1089/dia.2011.0171

[28] Shiloah, E., Witz, S., Abramovitch, Y., Cohen, O., Buchs, A., Ramot, Y., et al. (2003) Effect of acute psychotic stress in nondiabetic subjects on B-cell function and insulin sensitivity. Diabetes Care, 26, 1462-1467. http://care.diabetesjournals.org/content/26/5/1462.full.pdf http://dx.doi.org/10.2337/ diacare.26.5.1462

[29] De Groot, M., Auslander, W., Williams, J., Sherraden, M. and Haire-Joshu, D. (2003) Depression and poverty among African American women at risk for type 2 diabetes. Annals of Behavioral Medicine, 25, 172-181. http://www.ncbi.nlm.nih.gov/pubmed/12763712

[30] Krishnan, S., Cozier, Y., Rosenberg, L. and Palmer, J. (2010) Socioeconomic status and incidence of type 2 diabetes: Results from the Black women’s health study. American Journal of Epidemiology, 171, 564-570. http://www.ncbi.nlm.nih.gov/pubmed/20133518 http://dx.doi.org/10.1093/aje/ kwp443

[31] Wagner, J., Osborn, C., Mendenhall, E., Budris, L., Belay, S. and Tenner, H. (2011) Beliefs about racism and health among African American women with diabetes: A quailtative study. Journal of the National Medical Association, 103, 224-232. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082367/

[32] Chang, S., Kim, H., Yoon, K., Ko, S., Kwon, H., Kim, S., et al. (2004) Body mass index is the most important determining factor for the degree of insulin resistance in non-obese type 2 diabetic patients in Korea. Metabolism, 53, 142-146. http://www.ncbi.nlm.nih.gov/pubmed/14767863 http://dx.doi.org/10.1016/S0026-0495(03)00314-7

[33] Everson-Rose, S., Meyer, P., Powell, L., Pandey, D., Torrens, J., Kravitz, J., et al. (2004) Depressive symptoms, insulin resistance, and risk of diabetes in women at midlife. Diabetes Care, 27, 2856-2862. http://www.ncbi.nlm.nih.gov/pubmed/15562197

[34] Torrens, J., Skurnick, J., Davidow, A., Korenman, S., Santoro, N., Soto-Greene, M., et al. (2004) Ethnic differences in insulin sensitivity and B-cell function in premenopausal or early perimenopausal women without diabetes. Diabetes Care, 27, 354-361. http://care.diabetesjournals.org/content/27/2/ 354.full.pdf http://dx.doi.org/10.2337/diacare.27.2.354

[35] Fisher, L., Skaff, M., Mullan, J., Arean, P., Mohr, D., Masharani, U., et al. (2007) Clinical depression versus distress among patients with type 2 diabetes. Diabetes Care, 30, 542-548. http://www.ncbi.nlm.nih.gov/pubmed/17327318 http://dx.doi.org/10.2337/dc06-1614

[36] Miller, S. (2011) Diabetes and psychological profile of younger rural African American women with type 2 diabetes. Journal of Health Care for the Poor and Undeserved, 22, 1239-1252. http://www.ncbi.nlm.nih.gov/pubmed/22080706

[37] Huffman, F., Vaccaro, J., Ajabshir, S., Zarini, G., Exebio, J. and Dixon, Z. (2013) Perceived stress and self-rated health of Haitian and African Americans with and without type 2 diabetes. Journal of Research in Medical Science, 18, 198-204. http://www.ncbi.nlm.nih.gov/pubmed/23930115