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 AJPS  Vol.4 No.11 , November 2013
Evaluation of Antibacterial and Antidiarrhoeal Activities of Feronia limonia Leaf Extract
Abstract: The present study was carried out to investigate possible antibacterial and antidiarrhoeal activities of ethanol extract of Feronia limonia leaves. Phytochemical analysis of the crude extract was performed to detect presence of different kinds of phytoconstituents. The antibacterial activity was investigated against four Gram positive and four Gram negative bacteria by using disc diffusion method. The plant extract showed moderate antibacterial activity against Gram positive bacteria namely Staphylococcus saprophyticus and Staphylococcus pyogenes and all tested Gram negative bacteria namely Escherichia coli, Shigella boydii, Shigella dysentery and Shigella flexneri in dose dependant manner. The results of castor oil-induced diarrhoeal study showed that Feronia limonia extract significantly reduced the severity & frequency of diarrhoea in mice at a higher dose of 500 mg/kg compared with the standard drug loperamide (25 mg/kg). The present study clearly supports the medicinal value of this plant. The overall results indicate the possibility of presence of some active principles in the plant extract possessing antibacterial and antidiarrhoeal actions.
Cite this paper: M. Motalib Momin, M. Khan, J. Rayhan, A. Afrose, S. Rana and A. Begum, "Evaluation of Antibacterial and Antidiarrhoeal Activities of Feronia limonia Leaf Extract," American Journal of Plant Sciences, Vol. 4 No. 11, 2013, pp. 2181-2185. doi: 10.4236/ajps.2013.411270.
References

[1]   A. J. Alanis, “Resistance to Antibiotics: Are We in the Post-Antibiotics Era?” Archives of Medical Research, Vol. 36, No. 6, 2005, pp. 697-705.
http://dx.doi.org/10.1016/j.arcmed.2005.06.009

[2]   J. D. Snyder and M. H. Merson, “The Magnitude of the Global Problem of Acute Diarrhea Disease: A Review of Active Surveillance of Data,” Bulletin of the WHO, Vol. 60, No. 4, 1982, pp. 605-613.

[3]   K. Park, “Park’s Text Book of Preventive and Social Medicine,” Banarsidas Bharat Publishers, Jabalpur, 2000, pp. 122-175.

[4]   Anonymous, “Diarrhoeal Disease Control Program,” Weekly Epidemic Record, Vol. 16, 1979, p. 121.

[5]   L. Zhu, Y. J. Tian, L. Yang and J. G. Jiang, “Chemical Composition and Antimicrobial Activities of Essential Oil of Blumea megacephala,” EXCLI Journal, Vol. 10, 2011, pp. 62-68.

[6]   D. L. Dreyer, M. V. Pickering and P. Cohan, “Distribution of Limonoids in the Rutaceae,” Phytochemistry, Vol. 11, No. 2, 1972, pp. 705-713.
http://dx.doi.org/10.1016/0031-9422(72)80036-0

[7]   J. D. Hooker, “The Flora of British India,” L. Reeve & Co, London, 1875, p. 178.

[8]   K. R. Kirtikar and B. D. Basu, “Indian Medicinal Plants,” Vol. I, 2nd Edition, Bishen Sigh Mahinder Pal Singh, Dehra Dun, 1998, pp. 496-498.

[9]   D. N. G. Bakshi, P. Sensarma and D. C. Pai, “A Lexicon of Medicinal Plants in India,” Naya Prokash, Calcutta, 2001, pp. 186-187.

[10]   S. M. Ahamed, K. N. Jayaveera, J. V. Rao and T. Nagarjan, “Hepatoprotective and Antioxidant Activity of Methanolic Extract of Feronia limonia Leaves on Paracetamol-Induced Hepatic Injury in Rats,” Advances in Pharmacology and Toxicology, Vol. 11, No. 1, 2010, pp. 47-53.

[11]   A. A. Rahuman, G. Gopalarkrishnan, G. Saleem, S. Arumugam and B. Himalayan, “Effect of Feronia limonia on Mosquito Larvae,” Fitoterapia, Vol. 71, No. 5, 2000, pp. 553-555. http://www.sciencedirect.com/science/article/pii/S0367326X00001647
http://dx.doi.org/10.1016/S0367-326X(00)00164-7


[12]   Y. Saima, A. K. Das, K. K. Sarkar, A. K. Sen and P. Sur, “An Antitumor Pectic Polysaccharide from Feronia limonia,” International Journal of Biological Macromolecules, Vol. 27, No. 5, 2000, pp. 333-335.
http://www.ncbi.nlm.nih.gov/pubmed/10998491
http://dx.doi.org/10.1016/S0141-8130(00)00134-3


[13]   R. K. Joshi, P. A. Patil, M. H. K. Mujawar, D. Kumar and S. D. Kholkute, “Hypoglycemic Activity of Aqueous Leaf Extract of Feronia elephantum in Normal and Streptozotocin-Induced Diabetic Rats,” Pharmacologyonline, Vol. 3, 2009, pp. 815-821.
http://pharmacologyonline.silae.it/front/archives_2009_3

[14]   B. D. Patel, R. Shrivastava and R. K. Uppadhyay, “Phytochemical and Pharmacological Studies of Root and Root Bark of Feronia limonia (L.) Swingle,” Indian Journal of Forestry, Vol. 5, No. 1, 1982, pp. 14-17.

[15]   Md. R. Ali, M. Hossain, J. F. Runa and Md. Hasanuzzaman, “Preliminary Cytotoxic Activity of Different Extracts of Averrhoa bilimbi (Fruits)”, International Current Pharmaceutical Journal, Vol. 2, No. 3, 2013, pp. 83-84.
http://www.icpjonline.com/documents/Vol2Issue3/09.pdf

[16]   S. C. Das, S. Sultana, S. Roy and S. S. Hasan, “Antibacterial and Cytotoxic Activities of Methanolic Extracts of Leaf and Fruit Parts of the Plant Averrhoa bilimbi (Oxalidaceae),” American Journal of Scientific and Industrial Research, Vol. 2, No. 4, 2011, pp. 531-536.
http://dx.doi.org/10.5251/ajsir.2011.2.4.531.536

[17]   Md. A. A. Sikder, A. K. M. N. Hossian, Md. M. Parvez, Md. A. Kaisar, I. Nimmi and M. A. Rashid, “Antioxidant Behavior of Two Bangladeshi Medicinal Plants: Kigelia pinnata and Mesua nagassarium,” Bangladesh Pharmaceutical Journal, Vol. 14, No. 1, 2011, pp. 27-30.

[18]   A. Ghani, “Medicinal Plants of Bangladesh: Chemical Constituents & Uses,” 2nd Edition, Asiatic Society of Bangladesh, Dhaka, 2003, pp. 1-16.

[19]   M. T. Trease and S. E. Evans, “The Phytochemical Analysis and Antibacterial Screening of Extracts of Tetracarpetum conophorum,” Journal—Chemical Society of Nigeria, Vol. 26, 1978, pp. 57-58.

[20]   A. L. Barry, “Procedures for Testing Antimicrobial Agents in Agar Media,” In: V. Lorian, Ed., Antibiotics in Laboratory Medicine, Willams and Wilkins Company, Baltimore, 1980, pp. 1-23.

[21]   A. W. Bauer, W. M. M. Kirby, J. C. Sherries and M. Truck, “Antibiotic Susceptibility Testing by Standardized Single Disc Method,” American Journal of Clinical Pathology, Vol. 45, No. 4, 1966, pp. 493-496.

[22]   M. S. Rahman and M. A. Rashid, “Antimicrobial Activity and Cytotoxicity of Eclipta prostrate,” Oriental Pharmacy and Experimental Medicine, Vol. 8, No. 1, 2008, pp. 47-52. http://dx.doi.org/10.3742/OPEM.2008.8.1.047

[23]   R. Yegnanarayan and D. S. Shostri, “Comparison of Antidiarrhoeal Activity of Sons Drugs in Experimental Diarrhea,” Indian Journal of Pharmacology, Vol. 14, No. 4, 1982, pp. 293-299.

[24]   R. H. Cichewicz and P. A. Thorpe, “The Antimicrobial Properties of Chile Peppers (Capsicum Species) and Their Uses in Mayan Medicine,” Journal of Ethnopharmacology, Vol. 52, No. 2, 1996, pp. 61-70.
http://dx.doi.org/10.1016/0378-8741(96)01384-0

[25]   D. Srinivasan, L. P. Perumalsamy, S. Nathan and T. Sures, “Antimicrobial Activity of Certain Indian Medicinal Plants Used in Folkloric Medicine,” Journal of Ethnopharmacology, Vol. 74, No. 3, 2001, pp. 217-222.
http://dx.doi.org/10.1016/S0378-8741(00)00345-7

[26]   S. C. Garg, “Antimicrobial Activity of the Essential Oil of Feronia elephantum Correa,” Indian Journal of Pharmaceutical Sciences, Vol. 63, No. 2, 2001, pp. 155-157.
http://www.ijpsonline.com/showBackIssue.asp?issn=0250-474X;year=2001;volume=63;issue=2;month=March-April

[27]   T. S. Gaginella, J. J. Stewart, W. A. Olsen and P. Bass, “Action of Recinoleic Acid and Structurally Related Fatty Acid on the Gastrointestinal Tract. II. Effect on Water and Electrolyte Absorption in Vitro,” Journal of Pharmacology and Experimental Therapeutics, Vol. 195, No. 2, 1975, pp. 355-356.
http://www.ncbi.nlm.nih.gov/pubmed/1185605

[28]   J. Bruneton, “Pharmacognosy, Phytochemistry, Medicinal Plants,” 3rd Edition, Intercept Ltd., Hampshire, 1999, pp. 385-386.

[29]   M. J. G. Farthing, “Diarrhoea: A Significant Worldwide Problem,” International Journal of Antimicrobial Agents, Vol. 14, No. 1, 2000, pp. 65-69.
http://www.ijaaonline.com/article/S0924-8579%2899%2900149-1
http://dx.doi.org/10.1016/S0924-8579(99)00149-1


[30]   K. D. Tripathy, “Essential of Medical Pharmacology,” Medical Publishers, Jaypee Brothers, New Delhi, 1994, p. 187.

[31]   J. Galvez, A. Zarzuelo, M. E. Crespo, M. D. Lorente, M. A. Ocete and J. Jimenez, “Antidiarrhoeic Activity of Euphorbia hirta Extract and Isolation of an Active Flavonoid Constituent,” Planta Medica, Vol. 59, No. 4, 1993, pp. 333-336. http://dx.doi.org/10.1055/s-2006-959694

[32]   V. S. N. Rao, F. A. Santos, T. T. Sobreika, M. F. Souza, L. L. Melo and E. R. Silveira, “Investigations on the Gastroprotective and Antidiarrhoeal Properties of Ternatin, a Tetramethoxyflavone from Egletes viscose,” Planta Medica, Vol. 63, No. 2, 1997, pp. 146-149.
http://dx.doi.org/10.1055/s-2006-957632

 
 
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