Homotopy analysis method (HAM) is employed to investigate amperometric biosensor at mixed enzyme kinetics and diffusion limitation. Mathematical modeling of the problem is developed utilizing non-Michaelis-Menten kinetics of the enzymatic reaction. Different results of the problem are obtained for different values of the dimensionless parameters. Accuracy of the obtained results is verified by comparing them with the available actual and simulated ones. It is concluded that the obtained solution can be considered as a promising one to investigate different aspects of the phenomena.
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