Background: Pleomorphic adenoma constitutes the most
common benign parotid gland tumor. Local recurrence after surgery has been
described in 1%-5% of cases, and malignant evolution in 2%-9% of
cases. Metastasizing pleomorphic adenomas has rarely been
reported. No histologic or molecular parameters exist at the present time that
could predict the development of metastasis in these neoplasms. Methods and Results: A 54-year-old woman had a superficial left
parotidectomy with facial nerve preservation for pleomorphic adenoma. She
developed two recurrences in 2000 and 2001, but 25 years later the first
operation she presented a metastasis in her right gluteal region with evidence
of local recurrence. Conclusion: Metastatizing
pleomorphic adenoma is a rare pathologic situation but, in case of swelling or
lump appearance in patients with pleomorphic adenoma history, it should be
taken in mind.
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