NS  Vol.5 No.11 , November 2013
Can the early bird catch the worm? Effects of early rising on leukocyte subsets via modification of autonomic nervous system and the effect on glucose levels
Abstract: The importance of sleep has been described in proverbs such as “the early bird catches the worm”. However, there are few scientific reports on the effects of early rising. Therefore, early risers (Group E) and late risers (Group L) were compared and the number and ratio of leukocytes, body temperature, glucose and its associated hormones were studied. Furthermore, each group was divided into two groups by the duration of sleep and the following four groups were compared: early risers with short sleep (Group E-S); early risers with long sleep (Group E-L); late risers with short sleep (Group L-S); and late risers with long sleep (Group L-L). Then, compared with Group L, Group E showed lower numbers and ratio of granulocytes and a higher ratio of lymphocytes showing parasympathetic nerve dominance. Group E showed higher levels of glucose and its related hormones than Group L, indicating sympathetic nerve dominance. Compared with Groups E-S and L-S, Groups E-L and L-L showed lower glucose and cortisol levels, respectively. These results indicated that early rising might affect leukocyte subsets, and adequate duration of sleep could decrease levels of glucose via modification of the autonomic nervous system.
Cite this paper: Watanabe, M. , Ling, Y. , Tomiyama, C. , Adachi, K. , Mori, H. , Nishijo, K. , Abo, T. and Akazawa, K. (2013) Can the early bird catch the worm? Effects of early rising on leukocyte subsets via modification of autonomic nervous system and the effect on glucose levels. Natural Science, 5, 1133-1138. doi: 10.4236/ns.2013.511139.

[1]   Adachi, K., Nishijo, K. and Abo, T. (2010) Those with the habit of going to sleep early show a higher ratio of lymphocytes while those with the habit of staying up late show a higher ratio of granulocytes. Biomedical Research, 31, 143-149.

[2]   Barrett-Connor, E. and Ferrara, A. (1998) Isolated postchallenge hyperglycemia and the risk of fatal cardiovascular disease in older women and men. The Rancho Bernardo Study. Diabetes Care, 21, 1236-1239.

[3]   Ren, J.P., Chen, D.N., Wang, S.H., Han, X.Q., Liang, R. and Wang, Z.P. (2012) Stratified analysis of blood lipids and glucose in annual check-ups for medical staff at a Beijing class A grade III hospital, and related intervention measures. HEP, 39, 530-534.

[4]   Hancox, R.J. and Landhuis, C.E. (2012) Association between sleep duration and haemoglobin A1c in young adults. Journal of Epidemiol Community Health, 66, 957961.

[5]   Gottlieb, D.J., Punjabi, N.M., Newman, A.B., Resnick, H.E., Redline, S., Baldwin, C.M. and Nieto, F.J. (2005) Association of sleep time with diabetes mellitus and impaired glucose tolerance. Archives of Internal Medicine, 165, 863-867.

[6]   Najafian, J., Mohamadifard, N., Siadat, Z.D., Sadri, G. and Rahmati, M.R. (2013) Association between sleep duration and diabetes mellitus: Isfahan Healthy Heart Program. Nigerian Journal of Clinical Practice, 16, 5962.

[7]   Abo, T, Kawamura, T. and Watanabe, H. (2005) Immunologic status of autoimmune diseases. Immunologic Research, 33, 23-34.

[8]   Abo, T. and Kawamura, T. (2002) Immunomodulation by the autonomic nervous system: Therapeutic approach for cancer, collagen diseases, and inflammatory bowel diseases. Therapeutic Apheresis, 6, 348-357.

[9]   Miyaji, C., Watanabe, H., Minagawa, M., Toma, H., Kawamura, T., Nohara, Y., Nozaki, H., Sato, Y. and Abo, T. (1997) Numerical and functional characteristics of lymphocyte subsets in centenarians. Journal of Clinical Immunology, 17, 420-429.

[10]   Kainuma, E., Watanabe, M., Tomiyama-Miyaji, C., Inoue, M., Kuwano, Y., Ren, H. and Abo, T. (2009) Association of glucocorticoid with stress-induced modulation of body temperature, blood glucose and innate immunity. Psychoneuroendocrinology, 34, 1459-1468.

[11]   Watanabe, M., Tomiyama-Miyaji, C., Kainuma, E., Inoue, M., Kuwano, Y., Ren, H., Shen, J. and Abo, T. (2008) Role of alpha-adrenergic stimulus in stress-induced modulation of body temperature, blood glucose and innate immunity. Immunology Letters, 115, 43-49.

[12]   Suzuki, S., Toyabe, S., Moroda, T., Tada, T., Tsukahara, A., Iiai, T., Minagawa, M., Maruyama, S., Hatakeyama, K., Endoh, K. and Abo, T. (1997) Circadian rhythm of leucocytes and lymphocytes subsets and its possible correlation with the function of the autonomic nervous system. Clinical & Experimental Immunology, 110, 500508.

[13]   Morselli, L., Leproult, R., Balbo, M. and Spiegel, K. (2010) Role of sleep duration in the regulation of glucose metabolism and appetite. Best Practice & Research Clinical Endocrinology & Metabolism, 24, 687-702.

[14]   Gangwisch, J.E., Feskanich, D., Malaspina, D., Shen, S. and Forman, J.P. (2013) Sleep duration and risk for hypertension in women: Results from the nurses’ health study. American Journal of Hypertension, 26, 903-911.

[15]   Ghalichi, L., Pournik, O., Ghaffari, M. and Vingard, E. (2013) Sleep quality among health care workers. Archives of Iranian Medicine, 16, 100-103.

[16]   Amato, G., Carella, C., Fazio, S., Montagna, L.M., Cittadini, A., Sabatini, D., MarcianoMone, C., Sacca, L. and Bellastella, A. (1993) Body composition, bone metabolism, and heart structure and function in growth hormone (GH)-deficiend adults before and after GH replacement therapy at low doses. JCE & M, 77, 1671-1976.