Model-based Analysis of Ventilation Inhomogeneity in Respiratory Mechanics

Christoph  Schranz; Kévin  Meffray; Claudius  Stahl; Knut  Möller

doi:10.4236/eng.2013.510B073

Christoph Schranz^*, Kévin Meffray, Claudius Stahl, Knut Möller

Abstract: Individualized models of respiratory mechanics help to reduce potential harmful effects of mechanical ventilation by supporting the evaluation of patient-specific lung protective ventilation strategies. Assessing ventilation inhomogeneities might be an important aspect in optimizing ventilator settings. The aim of this studyis to capture and analyze ventilation inhomogeneity by a mathematical model using clinical data. The results show that the lung physiology of mechanically ventilated patients without lung condition can be described by an inhomogeneity model revealing two alveolar compartments with median time constants of 0.4 and 3.9 s. Thus, the IHM in combination with specific ventilation maneuver might be suitable to capture lung physiology for model-based optimization of ventilator settings but requires additional image-based investigations to further support the validity of the model.

Keywords: Respiratory Mechanics; Inhomogeneity Model; Parameter Identification; Model-Based Therapy

Cite this paper: Schranz, C. , Meffray, K. , Stahl, C. and Möller, K. (2013) Model-based Analysis of Ventilation Inhomogeneity in Respiratory Mechanics. Engineering, 5, 363-367. doi: 10.4236/eng.2013.510B073.

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