ENG  Vol.5 No.10 B , October 2013
Multi-Layer Microbubbles by Microfluidics
Abstract: Multi-layer microbubble has great potential in enabling the corporation of medical imaging with tumor therapy such as drug and gene delivery of therapeutics or other functional materials in medical applications. Microfluidic technique has advanced over the last decade and showed great promise in replacing traditional microbubble generating method. In this paper, a multi-layer microbubble structure was produced with the aspect as potentially used for drug loaded microbubble contrast agents.
Cite this paper: Zhang, H. , Meng, H. , Sun, Q. , Liu, J. and Zhang, W. (2013) Multi-Layer Microbubbles by Microfluidics. Engineering, 5, 146-148. doi: 10.4236/eng.2013.510B031.

[1]   E. Talu, K. Hettiarachchi, R. L. Powell, A. P. Lee, P. A. Dayton, and M. L. Longo, “Maintaining Monodispersity in a Microbubble Population Formed by Flow-Focusing,” Langmuir, Vol. 24, 2008, pp. 1745-1749.

[2]   K. Y. Song, W. J. Zhang and M. M. Gupta, “Size-Controllable Monodispersed Microsphere Generation by Liquid Chopper Utilizing PZT Actuator,” Journal of Microelectromechanical Systems, Vol. 22, No. 1, 2013, pp. 147-151.

[3]   M. R. Kendall, D. Bardin, R. Shih, P. A. Dayton and A. P. Lee, “Scaled-Up Production Using Multi-Array Micro-fluidic Module for Medical Imaging and Drug Delivery,” Bubble Science, Engineering and Technology, Vol. 4, No. 1, 2012, pp. 12-20.

[4]   S. A. Peyman, R. H. Abou-Saleh, J. R. Mclaughlan, N. Ingram, B. R. G. Johnson, et al., “Expanding 3D Geometry for Enhanced On-Chip Microbubble Production and Single Step Formation of Liposome Modified Microbubbles,” Lab on Chip, Vol. 12, 2012, pp. 4544-4552.

[5]   E. Castro-Hernandez, W. van Hoeve, D. Lohse and J. M. Gordillo, “Microbubble Generation in a Co-Flow Device Operated in a New Regime,” Lab on Chip, Vol. 11, 2011, pp. 2023-2029.

[6]   W. Hoeve, B. Dollet, M. Versluis and D. Lohse, “Microbubble Formation and Pinch-Off Scaling Exponent in Flow Focusing Devices,” Physics of Fluids, Vol. 23, 2011, Article ID: 092001.

[7]   I. Lentacker, B. G. Geest, R. E. broucke, et al., “Ultrasound-Responsive Polymer Coated Microbubbles That Bind and Protect DNA,” Lamgmuir, Vol. 27, No. 17, 2006, pp. 341-334.