Primary Cervical Choriocarcinoma: Case Report and the Review of Literatures
Author(s)
N. Behtash,
M. Karimi Zarchi,
A. A. Shamshirsaz,
A. A. Shamshirsaz,
Ashrafosadt Miratashi-Yazd,
N. Mehrdad
Affiliation(s)
Gynecological Oncology Fellowship, Shahid Sadoughi University of Medical Science, Yazd, Iran.
Gynecological Oncology Fellowship, Shahid Sadoughi University of Medical Science, Yazd, Iran.
ABSTRACT
Background: Primary choriocarcinoma of the cervix is a very rare entity. Case: A 35-year-old patient had been admitted to our hospital with vaginal bleeding for 7 months. A cervical mass measured 4 × 4 cm was palpated on the anterior surface of the cervix. Biopsy of the lesion demonstrated extensive necrosis and was in favor of squamous cell carcinoma. Patient was accepted as FIGO stage Ib1-2 and underwent type II hysterectomy with bilateral salpingoopherectomy and bilateral pelvic lymph node dissection was carried out. Post operative pathologic evaluation of the surgical specimen evinced that the case was primary cervical choriocarcinoma. Conclusion: Primary choriocarcinoma of the cervix should be considered in patients in their reproductive years with cervical lesion and negative cervical cytology. Beta-hCG assay and transvaginal color Doppler sonography are useful for early diagnosis.
Cite this paper
N. Behtash, M. Zarchi, A. Shamshirsaz, A. Shamshirsaz, A. Miratashi-Yazd and N. Mehrdad, "Primary Cervical Choriocarcinoma: Case Report and the Review of Literatures," Journal of Cancer Therapy, Vol. 4 No. 8, 2013, pp. 1335-1340. doi: 10.4236/jct.2013.48158.
N. Behtash, M. Zarchi, A. Shamshirsaz, A. Shamshirsaz, A. Miratashi-Yazd and N. Mehrdad, "Primary Cervical Choriocarcinoma: Case Report and the Review of Literatures," Journal of Cancer Therapy, Vol. 4 No. 8, 2013, pp. 1335-1340. doi: 10.4236/jct.2013.48158.
References
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http://dx.doi.org/10.1046/j.1525-1438.2001.01005.x [11] H. Sonobe, K. Taguchi, K. Ogawa and T. Yoshioka, “Latent Vaginal Choriocarcinoma in a Postmenopausal Woman,” Acta Pathologica Japonica, Vol. 26, 1976, pp. 611-618. [12] FIGO Oncology Committee Report, “FIGO Staging for Gestational Trophoblastic Neoplasia 2000,” International Journal of Gynecology & Obstetrics, Vol. 77, No. 3, 2002, pp. 285-287.
http://dx.doi.org/10.1016/S0020-7292(02)00063-2 [13] P. Y. Wel snd P. C. Ouyang, “Trophoblastic Disease in Taiwan: A Review of 157 Cases on a 10-Year Period,” American Journal of Obstetrics & Gynecology, Vol. 85, 1963, pp. 844-849. [14] P. C. Dyke and L. M. Fink, “Latent Choriocarcinoma,” Cancer, Vol. 20, No. 1, 1967, pp. 150-154. http://dx.doi.org/10.1002/1097-0142(1967)20:1<150::AID-CNCR2820200121>3.0.CO;2-9 [15] W. Park, “Choriocarcinoma: A Study of Its Pathology,” F. A. Davis, Philadelphia, 1971. [16] N. Tsukamoto, M. Nakamura, M. Kashimura and T. Saito, “Primary Cervical Choriocarcinoma,” Gynecologic Oncology, Vol. 9, No. 1, 1980, pp. 99-107. http://dx.doi.org/10.1016/0090-8258(80)90014-1 [17] E. Kairi-Vassilatou, K. Papakonstantinou, D. Grapsa, A. Kondi-Paphiti and D. Hasiakos “Primary Gestational Choriocarcinoma of the Uterine Cervix,” International Journal of Gynecological Cancer, Vol. 17, No. 4, 2007, pp. 921-925. http://dx.doi.org/10.1111/j.1525-1438.2006.00852.x [18] A. Ben-Chetrit, S. Yagel, I. Ariel, D. Zacut, S. Shimonovitz and D. Ceinikier-Hochner, “Successful Conservative Management of Primary Nonmetastatic Cervical Choriocarcinoma,” American Journal of Obstetrics & Gynecology, Vol. 163, No. 4, 1990, pp. 1161-1163. http://dx.doi.org/10.1016/0002-9378(90)90679-2