PSYCH  Vol.4 No.10 A , October 2013
Neural Substrates of Forward and Backward Associative Priming: A Functional MRI Study
ABSTRACT

Forward associative priming results of an association moves from the prime to the target whereas backward associative priming results of an association from the target to the prime (Koivisto, 1998). Little is known about this dissociation of process and the associated cerebral substrates. Fourteen healthy participants were included in this study. The task consisted in a lexical decision task using an fMRI-adapted semantic priming paradigm. Contrasts between forward related and forward unrelated conditions showed activation in the left temporal gyrus, left inferior prefrontal cortex, fusiform gyrus and occipital regions and cerebellum. Investigation of the different patterns of activation between forward and backward priming shows significant results: during the contrast between the forward priming effect and the backward priming effect, we observe a deactivation of BOLD response in temporal and frontal areas, which may reflect the post-lexical integration process. So, areas responsible for language and for decoding spelling seem not to be involved in the backward process. An adaptation of this research in event-related brain potentials is underway to better explore the temporality of post-lexical process.


Cite this paper
Terrien, S. , Gierski, F. , Caillies, S. , Baltazart, V. , Portefaix, C. , Pierot, L. and Besche-Richard, C. (2013) Neural Substrates of Forward and Backward Associative Priming: A Functional MRI Study. Psychology, 4, 34-41. doi: 10.4236/psych.2013.410A007.
References
[1]   Argyropoulos, G. (2011). Cerebellar theta-burst stimulation selectively enhances lexical associative priming. Cerebellum, 10, 540-550.
http://dx.doi.org/10.1007/s12311-011-0269-y

[2]   Behrmann, M., Nelson, J. J., & Sekuler, E. B. (1998). Visual complexity in letter-by-letter reading: “Pure” alexia is not pure. Neuropsychologia, 36, 1115-1132.
http://dx.doi.org/10.1016/S0028-3932(98)00005-0

[3]   Bellebaum, C., & Daum, I. (2011). Mechanisms of cerebellar involvement in associative learning. Cortex, 47, 128-136.
http://dx.doi.org/10.1016/j.cortex.2009.07.016

[4]   Besche, C., Passerieux, C., Segui, J., Sarfati, Y., Laurent, J. P., & Hardy-Baylé, M. C. (1997). Syntactic and semantic processing in schizophrenic patients evaluated by lexical-decision tasks. Neuropsychology, 4, 498-505.
http://dx.doi.org/10.1037/0894-4105.11.4.498

[5]   Blumstein, S. E., Milberg, W., & Shrier, R. (1982). Semantic processing in aphasia: Evidence from an auditory lexical decision task. Brain and Language, 17, 301-315.
http://dx.doi.org/10.1016/0093-934X(82)90023-2

[6]   Catani, M., Dell’Acqua, F., Vergani, F., Malik, F., Hodge, H., Roy, P., et al. (2012). Short frontal lobe connections of the human brain. Cortex, 48, 273-291. http://dx.doi.org/10.1016/j.cortex.2011.12.001

[7]   Chwilla, D. J., Hagoort, P., & Brown, C. M. (1998). The mechanism underlying backward priming in a lexical decision task: Spreading activation versus semantic matching. The Quarterly Journal of Experimental Psychology A: Human Experimental Psychology, 51A, 531-560. http://dx.doi.org/10.1080/027249898391521

[8]   Copland, D. A., de Zubicaray, G. I., McMahon, K., Wilson, S. J., Eastburn, M., & Chenery, H. J. (2003). Brain activity during automatic semantic priming revealed by event-related functional magnetic resonance imaging. NeuroImage, 20, 302-310.
http://dx.doi.org/10.1016/S1053-8119(03)00279-9

[9]   Daselaar, S., Rombouts, S., Veltman, D., Raaijmakers, J., Lazeron, R., & Jonker, C. (2001). Parahippocampal activation during successful recognition of words: A self-paced event-related fMRI study. Neuro-Image, 13, 1113-1120. http://dx.doi.org/10.1006/nimg.2001.0758

[10]   Franklin, M. S., Dien, J., Neely, H. N., Huber, E., & Waterson, L. D. (2007). Semantic priming modulates the N400, N300, and N400RP. Clinical Neurophysiology, 118, 1053-1068.
http://dx.doi.org/10.1016/j.clinph.2007.01.012

[11]   Gainotti, G. (2006). Anatomical functional and cognitive determinants of semantic memory disorders. Neuroscience and Biobehavioral Reviews, 30, 577-594.
http://dx.doi.org/10.1016/j.neubiorev.2005.11.001

[12]   Gebhart, A. L., Petersen, S. E., & Thach, W. T. (2002). Role of the posterolateral cerebellum in language. In S. M. Highstein, & W. Thach (Eds.), The cerebellum: Recent developments in cerebellar research (pp. 318-333). New York: New York Academy of Sciences.

[13]   Gordon, N. (1996). Speech, language, and the cerebellum. European Journal of Disorders of Communication, 31, 359-367.
http://dx.doi.org/10.3109/13682829609031327

[14]   Hagoort, P. (1993). Impairments of lexical-semantic processing in aphasia: Evidence from the processing of lexical ambiguities. Brain and Language, 45, 189-232. http://dx.doi.org/10.1006/brln.1993.1043

[15]   Hagoort, P. (1997). Semantic priming in Broca’s aphasics at a short SOA: No support for an automatic access deficit. Brain and Language, 56, 287-300. http://dx.doi.org/10.1006/brln.1997.1849

[16]   Henik, A., Dronkers, N. F., & Knight, R. T. (1993). Differential effects of semantic and identity priming in patients with left and right hemisphere lesions. Journal of Cognition and Neuroscience, 5, 45-55.
http://dx.doi.org/10.1162/jocn.1993.5.1.45

[17]   Kahan, T. A., Neely, J. H., & Forsythe, W. J. (1999). Dissociated backward priming effects in lexical decision and pronunciation tasks. Psychonomic Bulletin and Review, 6, 105-110.
http://dx.doi.org/10.3758/BF03210816

[18]   Kandhadai, P., & Federmeier, K. D. (2010). Automatic and controlled aspects of lexical associative processing in the two cerebral hemispheres. Psychophysiology, 47, 774-785.
http://dx.doi.org/10.1111/j.1469-8986.2009.00969.x

[19]   Ketteler, D., Kastrau, F., Vohn, R., & Huber, W. (2008). The subcortical role of language processing. High level linguistic features such as ambiguity-resolution and the human brain: An fMRI study. Neuro-Image, 39, 2002-2009.
http://dx.doi.org/10.1016/j.neuroimage.2007.10.023

[20]   Koivisto, M. (1998). Backward priming and postlexical processing in the right hemisphere. Laterality, 3, 21-40.
http://dx.doi.org/10.1080/135765098397386

[21]   Koriat, A. (1981). Semantic facilitation in lexical decision as a function of prime-target association. Memory and Cognition, 9, 587-598.
http://dx.doi.org/10.3758/BF03202353

[22]   Leiner, H. C., Leiner, A. L., & Dow, R. S. (1993). Cognitive and language functions of the human cerebellum. Trends in Neurosciences, 16, 444-447. http://dx.doi.org/10.1016/0166-2236(93)90072-T

[23]   Maldjian, J. A., Laurienti, P. J., & Burdette, J. H. (2004). Precentralgyrus discrepancy in electronic versions of the Talairach atlas. NeuroImage, 21, 450-455.
http://dx.doi.org/10.1016/j.neuroimage.2003.09.032

[24]   Maldjian, J. A., Laurienti, P. J., Kraft, R. A., & Burdette, J. H. (2003). An automated method for neuroanatomic and cytoarchitectonic atlasbased interrogation of fMRI data sets. NeuroImage, 19, 1233-1239. http://dx.doi.org/10.1016/S1053-8119(03)00169-1

[25]   Marien, P., Engelborghs, S., & De Deyn, P. (2001). Cerebellar neuroncognition: A new avenue. ActaNeurologicaBelgica, 101, 96-109.

[26]   Matsumoto, A., Iidaka, T., Haneda, K., Okada, T., & Sadato, N. (2005). Linking semantic priming effect in functional MRI and event-related potentials. NeuroImage, 24, 624-634.
http://dx.doi.org/10.1016/j.neuroimage.2004.09.008

[27]   Meyer, D. E., & Schvaneveldt, R. W. (1971). Facilitation in recognizing pairs of words: Evidence of a dependence between retrieval operations. Journal of Experimental Psychology, 90, 227-234.
http://dx.doi.org/10.1037/h0031564

[28]   Milberg, W., Blumstein, S. E., Katz, D., Gershberg, F., & Brown, T. (1995). Semantic facilitation in aphasia: Effects of time and expectancy. Journal of Cognition and Neuroscience, 7, 33-50.
http://dx.doi.org/10.1162/jocn.1995.7.1.33

[29]   Mummery, C. J., Shallice, T., & Price, C. J. (1999). Dual-process model in semantic priming: A functional imaging perspective. NeuroImage, 9, 516-525. http://dx.doi.org/10.1093/cercor/bhp055

[30]   Neely, J. H. (1991). Semantic priming effects in visual word recognition: A selective review of current findings and theories. In D. Besner, & G. W. Humphreys (Eds.), Basic processes in reading: Visual word recognition (pp. 264-336). Hillsdale, NJ: Lawrence Erlbaum Associates, Inc.

[31]   Neely, J. H., Keefe, D. E., & Ross, K. L. (1989). Semantic priming in the lexical decision task: Roles of prospective prime-generated expectancies and retrospective semantic matching. Journal of Experimental Psychology: Learning, Memory, and Cognition, 15, 1003-1019. http://dx.doi.org/10.1037/0278-7393.15.6.1003

[32]   Nobre, A. C., Allison, T., & McCarthy, G. J. (1994).Word recognition in the human inferior temporal lobe. Nature, 372, 260-273.
http://dx.doi.org/10.1038/372260a0

[33]   Nobre, A. C., & McCarthy, G. J. (1995). Language-related field potentials in the anteriormedial temporal lobe: II. Effects of word type and semantic priming. Journal of Neuroscience, 15, 1090-2008.

[34]   O’Hare, A. J., Dien, J., Waterson, L. D., & Savage, C. R. (2008). Activation of the posterior cingulate by semantic priming: A co-Registered ERP/fMRI study. Brain Research, 1189, 97-114.
http://dx.doi.org/10.1016/j.brainres.2007.10.095

[35]   Oldfield, R. C. (1971). The assessment and analysis of handedness: The Edinburgh inventory. Neuropsychologia, 9, 97-114.
http://dx.doi.org/10.1016/0028-3932(71)90067-4

[36]   Philipose, L. E., Gottesman, R. F., Newhart, M., Kleinman, J. T., Herskovits, E. H., Pawlak, M. A., et al. (2007). Neural regions essential for reading and spelling of words and pseudowords. Annals of Neurology, 62, 481-492. http://dx.doi.org/10.1002/ana.21182

[37]   Pulvermüller, F. (2012). Meaning and the brain: The neurosemantics of referential, interactive, and combinatorial knowledge. Journal of Neurolinguistics, 25, 423-459.
http://dx.doi.org/10.1016/j.jneuroling.2011.03.004

[38]   Rossel, S. L., Bullmore, E. T., Williams, S. C. R., & David, A. S. (2001). Brain activation during automatic and controlled processing of semantic relations: A priming experiment using lexical-decision. Neuropsychologia, 39, 1167-1176.
http://dx.doi.org/10.1016/S0028-3932(01)00049-5

[39]   Sabb, F. W., Bilder, R. M., Chou, M., & Bookheimer, S. Y. (2007). Working memory effects on semantic processing: Priming differences in pars orbitalis. NeuroImage, 37, 311-322.
http://dx.doi.org/10.1016/j.neuroimage.2007.04.050

[40]   Sass, K., Krach, S., Sachs, O., & Kircher, T. (2009). Lion-tiger-stripes: Neural correlates of indirect semantic priming across processing modalities. NeuroImage, 45, 224-236.
http://dx.doi.org/10.1016/j.neuroimage.2008.10.014

[41]   Schmahmann, J. D., & Pandya, D. N. (1997). The cerebrocerebellar system. International Review of Neurobiology, 41, 31-60.
http://dx.doi.org/10.1016/S0074-7742(08)60346-3

[42]   Simon, J. S., Koutstaal, W., Pince, S., Wagner, A. D., & Schacter, D. L. (2003). Neural mechanisms of visual object priming: Evidence for perceptual and semantic distinctions in fusiform cortex. NeuroImage, 19, 613-626. http://dx.doi.org/10.1016/S1053-8119(03)00096-X

[43]   Starrfelt, R., Habekost, T., & Leff, A. (2009). Too little, too late: Reduced visual span and speed characterize pure alexia. Cerebral Cortex, 19, 2880-2890. http://dx.doi.org/10.1093/cercor/bhp059

[44]   Stowe, L. A., Paans, A. M., Wijers, A. A., Zwarts, F., Mulder, G., & Vaalburg, W. (1999). Sentence comprehension and word repetition: A positron emission tomography investigation. Psychophysiology, 36, 786-801. http://dx.doi.org/10.1111/1469-8986.3660786

[45]   Timmann, D., Drepper, J., Frings, M., Maschke, M., Richter, S., Gerwig, M., et al. (2010). The human cerebellum contributes to motor, emotional and cognitive associative learning: A review. Cortex, 46, 845-857. http://dx.doi.org/10.1016/j.cortex.2009.06.009

[46]   Tzourio-Mazoyer, N. N., Landeau, B. B., Papathanassiou, D. D., Crivello, F. F., Etard, O. O., Delcroix, N. N., et al. (2002). Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. Neuro-Image, 15, 273. http://dx.doi.org/10.1006/nimg.2001.0978

[47]   Wagner, A. D., Paré-Blagoev, E. J., Clark, J., & Poldrack, R. A. (2001). Recovering meaning: Left prefrontal cortex guides controlled semantic retrieval. Neuron, 2, 329-338.
http://dx.doi.org/10.1016/S0896-6273(01)00359-2

 
 
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