ENG  Vol.4 No.10 , October 2012
The COP9 Signalosome Controls Adipocyte Differentiation by Regulating CHOP Protein Stability
Abstract

Obesity is a serious health problem of our time. Dysfunction of adipogenesis, the differentiation of adipocytes, is a hallmark of obesity. Therefore here we investigate the role of the COP9 signalosome and of CHOP in the differentiation of LiSa-2 preadipocytes.


Cite this paper
X. Huang and W. Dubiel, "The COP9 Signalosome Controls Adipocyte Differentiation by Regulating CHOP Protein Stability," Engineering, Vol. 4 No. 10, 2012, pp. 192-193. doi: 10.4236/eng.2012.410B050.
References

[1]   Li, X. et al. (2006) Lactacystin inhibits 3T3-L1 adipocyte differentiation through induction of CHOP-10 expression. Biochem. Biophys. Res. Commun. 350, 1-6.

[2]   Wei, N., Chamovitz, D.A. and Deng, X.W. (1994) Arabidopsis COP9 is a component of a novel signaling complex mediating light control of development. Cell 78, 117-124.

[3]   Deshaies, R.J. and Joazeiro, C.A. (2009) RING domain E3 ubiquitin ligases. Annu. Rev. Biochem. 78, 399-434.

[4]   Cope, G.A., Suh, G.S., Aravind, L., Schwarz, S.E., Zipursky, S.L., Koonin, E.V. and Deshaies, R.J. (2002) Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1. Science 298, 608-611.

[5]   Rogalla, S., Geier, C.F., Braumann, C., Ordemann, J., Müller, J.M. and Dubiel, W. (2010) in: 45th Congress of the European Society for Surgical Research - ESSR -, Vol. 45, pp. 17-23 (Cikirikcioglu, M., Ed.) MEDIMOND, Geneva, Switzerland.

[6]   Braumann, C., Tangermann, J., Jacobi, C.A., Muller, J.M. and Dubiel, W. (2008) Novel anti-angiogenic compounds for application in tumor therapy - COP9 signalosome-associated kinases as possible targets. Mini Rev Med Chem 8, 421-428.

[7]   Aggarwal, B.B. (2010) Targeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals. Annu. Rev. Nutr. 30, 173-199.

 
 
Top