OJOG  Vol.3 No.8 , October 2013
Spot urine protein/creatinine ratio—A quick and accurate method for diagnosis of pre-eclampsia
ABSTRACT

Objective(s):To assess the diagnostic accuracy of spot urine protein-creatinine (P/C) ratio and its compareson with 24-hour urine proteinuria for predicting eclampsia. Method(s): Spot urine P/C ratio was determined in a mid-stream urine sample, and the 24-hour urine protein was measured. The correlation between the spot P/C ratio and 24-hour urine protein amount was done. Logistic regression analysis and ROC curve analysis have been used to analyse data. Result(s): There was a strong correlation between the spot P/C ratio and 24-hour urine protein excretion (pearson’s correlation coefficient r = 0.71; P < 0.0001). The optimal spot P/C ratio cutoff point was 0.25, for 300 mg/24 h of protein excretion, with sensitivity and specificity of 69% and 75% respectively. Conclusion(s): Spot urine P/C ratio is a quick and reliable tool which can be used as an alternative method for evaluation of proteinuria for diagnosis of pre-eclampsia.


Cite this paper
Sharma, A. , Kiran, P. and Ajai, B. (2013) Spot urine protein/creatinine ratio—A quick and accurate method for diagnosis of pre-eclampsia. Open Journal of Obstetrics and Gynecology, 3, 609-612. doi: 10.4236/ojog.2013.38109.
References
[1]   Majhi, A.K., Mondal, A. and Mukherjee, G.G. (2001) Safe motherhood—A long way to achieve. Journal of Indian Medical Association, 99, 132-137.

[2]   Granger, J.P., Alexander, B.T., Llinas, M.T., Bennett, W.A., Khalil, R.A. (2001) Pathophysiology of hypertension during pre-eclampsia linking placental ischemia with endothelial dysfunction. Hypertension, 38, 718-722. http://dx.doi.org/10.1161/01.HYP.38.3.718

[3]   (2000) Report of the national high blood pressure education program working group on high blood pressure in pregnancy. American Journal of Obstetrics and Gynecology, 183, S1-S22.
http://dx.doi.org/10.1067/mob.2000.107928

[4]   Al, R.A., Baykal, C., Karacay, O., Geyik, P.O., Altun, S. and Doten, I. (2004) Random urine protein creatinine ratio to predict protenuria in new onset mild hypertension in late preganncy. Obstetrics & Gynecology, 104, 367-371. http://dx.doi.org/10.1097/01.AOG.0000134788.01016.2a

[5]   Eigbejoh, J.O., Abebe, J., Odike, M.A. and Isabu, P. (2007) Protein/creatinine ratio in random urine specimen for quantitation of proteinuria in pre-eclampsia. Internet Journal of Gynecology & Obstetrics, 7, 6.

[6]   Durnwald, C. and Mercer, B. (2003) A prospective comparison of total protein/creatinine ratio versus 24-hour urine protein in women with suspected pre-eclampsia. American Journal of Obstetrics & Gynecology, 189, 848-852. http://dx.doi.org/10.1067/S0002-9378(03)00849-4

[7]   Wheeler 2nd, T.L., Blackhurst, D.W., Dellinger, E.H. and Ramsey, P.S. (2007) Usage of spot urine protein to creatinine ratios in the evaluation of pre-eclampsia. American Journal of Obstetrics & Gynecology, 196, 465e1-4.

[8]   Shahbazian, N. and Farjanet Hosseini-Asl, F. (2008) A comparison of spot urine protein-creatinine ratio with 24-hours urine protein excretion in women with pre-eclampsia. Iranian Journal of Kidney Diseases, 2,127-131.

 
 
Top