ABSTRACT To investigate the effect of Flunixin meglumine- a NSAID; alone and in combination with hypertonic saline on endotoxemic buffalo calves, two groups of five apparently healthy male buffalo calves aged be-tween 6-8 months were subjected to I.V. infusion of E.coli endotoxin at the rate of 5μg/kg BW per hour for 3 hours. A highly significant (P < 0.01) fall in mean systolic,diastolic, pulse, mean arterial pressure (M.A.P), central venous pressure (C.V.P) and haemo-globin was observed till the end of endotoxin infusion while respiratory rate was significantly elevated along with a non-significant alteration in rectal tem-perature and hematocrit during the infusion of en-dotoxin. Immediately at the end of endotoxin infusion, flunixin meglumine at the rate of 1.1 mg/kg B.W was infused i.v. in group-I animals and group-II animals were infused with hypertonic saline solution (H.S.S.) at the rate of 4 ml/Kg BW as one time infusion fol-lowed by flunixin meglumine at the rate of 1.1 mg/kg B.W which resulted in increase of various parameters either to normal or very close to normal value while the rectal temperature and haematocrit decreased non-significantly throughout the observation period of 7 hours. No improvement in Hb and respiration was observed consequent to FM administration. Both treatments successfully raised systolic, diastolic, pulse pressure, C.V.P & M.A.P to normal pre-infusion val-ues. From the results of the present investigation, it can be concluded that i.v. infusion of FM alone and in combination with hypertonic saline solution in en-dotoxemic buffalo calves effectively restores the various hemodynamic parameters close to normal pre-infusion values and it can be used as immediate resuscitation measure to provide the clinician valu-able time to plan further long term treatment.
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nullSingh, D. , Bansal, S. and Ghumman, G. (2011) Effect of flunixin meglumine alone and in combination on haemodynamics during bovine endotoxic shock and after treatment. Journal of Biomedical Science and Engineering, 4, 29-33. doi: 10.4236/jbise.2011.41004.
 Semrad, S.D. (1993) Comparative efficiency of flunixin, ketoprofen and ketorolac for treating endotoxemine neonatal calves. American Journal of Veterinary Research, 54, 1511-1516.
Ng, S.W., Zhang, H., Hedge, A. and Bhatia, M. (2008) Role of preprotachykinin—A gene products on multiple organ injury in LPS- induced endotoxemia. Journal of leucocyte Biology, 83, 288-95.
Singh, D.V., Singh, R.V. and Sodhi, S.P.S. (2002) Effect of HSS on haemodynamics of endotoxemic buffalo calves. Indian Journal of Animal Sciences, 72, 1083- 1086.
Dacie, J.V. and Lewis, S.M. (1975) Practical hematology. 5th Edition, Churchill Livingstone, London.
Snedecor, G.W. and Cochran, W.G. (1976) Statistical methods. Iowa State College Printing Press, Iowa, USA.
Singh, D.V., Singh, R.V. and Sodhi, S.P.S (2005) Effect of blood transfusion in combination with Dextran-40 and hypertonic Saline Solution on cardiopulmonary haemodynamics of endotoxic shock in buffalo calves. Veterinary Research Communication, 29, 421-430. doi:10.1007/s11259-005-1434-x
Singh, K., Krishnamurthy, D. and Peskin, P.K. (1997) Endotoxin shock with and without dexamethasone pre- treatment in anaesthetized buffalo calves. II. Indian Journal of Veterinary Surgery, 18, 8-11.
Margolis, J.H., Buttons, G.D. and Fessler, J.F. (1987). The efficacy of dexamethasone and flunixin meglumine in treating endotoxin induced changes in calf. Veterinary Research Communications, 11, 479-491. doi:10.1007/BF00380630
Jean, G.S., Constable, P.D., and Yvorchok, M. (1993) The clinical use of hypertonic saline solution in food animals with haemorrhagic and endotoxic shock. Agricultural Practice, 14, 6-11.
Olson, N.C., Hellyer, P.W. and Dodam, J.R. (1995) Mediators and vascular effects in response to endotoxin. British Veterinary Journal, 151, 489-521. doi:10.1016/S0007-1935(05)80023-5
Sobti, V.K., Mirakhur, K.K., Krishnamurthy, D. and Nigam, J.M. (1981) Ringer’s lactate and homologous blood transfusion in hemorrhagic shock in buffalo calves. Indian journal of experimental Biology, 19, 371-374.
Singh, J. (1979). An investigation into Patho-Physiology and treatment of shock in bovines, Ph.D. dissertation, Punjab Agricultural University, Ludhiana, India.
Constable, P.D., Schmall, M., Muir, W.W., Hoffsis, G.F. and Shertel, E.R. (1991) Haemodynamic response of endotoxemic calves to treatment with small volume HSS. American Journal of Veterinary Research, 52, 981-989.
Dupe, R., Bywater, R.J. and Goddard, M. (1993) A hypertonic saline infusion in treatment of experimental shock in calves and clinical shock in dogs and cats. Veterinary Record, 133, 585-590.
 Constable, P.D., Gohar, H.M., Morin, D.E. and Thurmon J.C. (1996). Use of hypertonic saline- dextrin solution to resuscitate hypovolemic calves with diarrhoea. American Journal of Veterinary Research, 57, 97-104.
Kopcha, M. and Ahl, A.S. (1989) Experimental use of flunixin meglumine and phenyl butazone in food producing animals. Journal of American Veterinary Research Communications, 11, 479-491.