JBNB  Vol.4 No.4 , October 2013
Upon the Delivery Properties of a Polymeric System Based on Poly(2-Hydroxyethyl Methacrylate) Prepared with Protective Colloids
Abstract: A comparative study related to the preparation of poly(2-hydroxyethyl methacrylate) (pHEMA) through radical polymerization process in the presence of three different protective colloid substances, respectively poly(vinyl alcohol) (PVA), β-cyclodextrin, or poly(aspartic acid) (PAS), is presented. The dependence of the thermal behavior of the polymers as well as their morphological aspect, on the protective colloids used in synthesis was evidenced by polymers characterization. It is also demonstrated that the swelling capacity is dependent on the protective colloid variant present during the pHEMA preparation. This behavior induces as well interdependence on the ability to load bioactive compounds onto the polymeric matrices. The distribution of the indomethacin (INN), as model drug, into the pHEMA network was put into evidence by near infrared chemical imaging (NIR-CI), a non-destructive technique and with its correspondingly statistical analysis.
Cite this paper: L. Nita, A. Chiriac, M. Nistor and T. Budtova, "Upon the Delivery Properties of a Polymeric System Based on Poly(2-Hydroxyethyl Methacrylate) Prepared with Protective Colloids," Journal of Biomaterials and Nanobiotechnology, Vol. 4 No. 4, 2013, pp. 357-364. doi: 10.4236/jbnb.2013.44045.

[1]   G. Mabilleau, C. Cincu, M. F. Basle and D. Chappard, “Polymerization of 2-(Hydroxyethyl Methacrylate by Two Different Initiator/Accelerator Systems: A Raman Spectroscopic Monitoring,” Journal of Raman Spectroscopy, Vol. 39, No. 7, 2008, pp. 767-771.

[2]   J. P. Montheard, J. Kahovec and D. Chappard, “Chapter 5,” In: R. Arshady, Ed., Desk Reference of Functional Polymers; Syntheses and Applications, American Chemical Society, Washington DC, 1997, pp. 699-750.

[3]   J. Barton and I. Capek, “Radical Polymerization in Disperse Systems,” Ellis Horwood, New York, 1994.

[4]   R. G. Gilbert, “Emulsion Polymerization: A Mechanistic Approach,” Academic Press, London, 1995.

[5]   R. M. Fitch, “Polymer Colloids: A Comprehensive Introduction,” Academic Press, London, 1997.

[6]   C. S. Chern, “Emulsion Polymerization Mechanisms and Kinetics,” Progress in Polymer Science, Vol. 31, No. 5, 2006, pp. 443-486.

[7]   A. P. Chiriac, L. E Nita and M. T. Nistor, “Copolymerization of 2-Hydroxyethyl Methacrylate with a Comonomer with Spiroacetal Moiety,” Journal of Polymer Science Part A: Polymer Chemistry, Vol. 49, No. 7, 2011, pp. 1543-1551.

[8]   H. H. Chu and C. S. Lin, “The Effect of Initiators on the Emulsion Polymerization of 2-Hydroxyethyl Methacrylate,” Journal of Polymer Research, Vol. 10, No. 4, 2003, pp. 283-287.

[9]   S. Rimmer, P. Tattersall, “The Inclusion of β-Cyclodextrin Provides a Supramolecular Solution to the Problem of Polymerization of Dodecyl and Octadecyl Methacrylates in Aqueous Emulsion,” Polymer, Vol. 40, No. 20, 1999, pp. 5729-5731.

[10]   T. Sun, J. Shen, H. Yan, J. Hao and A. Hao, “Stable Vesicles Assembled by ‘Supramolecular Amphiphiles’ with Double Hydrophobic Chains,” Colloids and Surfaces A: Physicochemical and Engineering Aspects, Vol. 414, 2012, pp. 41-49.

[11]   Y. Hou, F. Xin, M. Yin, Li Kong, H. Zhang, T. Sun, P. Xing and A. Hao, “Stimuli-Responsive Supramolecular Organogels That Exhibit a Succession of Micro-Morphologies,” Colloids and Surfaces A: Physicochemical and Engineering Aspects, Vol. 414, 2012, pp. 160-167.

[12]   L. E. Nita, A. P. Chiriac, S. Cimmino, C. Silvestre, D. Duraccio and C. Vasile, “Polymerization in Magnetic Field. Influence of Surfactant Nature on the Polymerization Reaction and on Thermal Properties of PMMA and MMA-Co-GMA Copolymers,” Polymer International, Vol. 57, No. 2, 2008, pp. 342-349.

[13]   A. P. Chiriac, L. E. Nita, I. Neamtu and M. Bercea, “Contribution to Polymer Nanoparticles Analysis by Laser Light Scattering,” Polymer Testing, Vol. 28, No. 8, 2009, pp. 886-890.

[14]   L. E. Nita, A. P. Chiriac, C. M. Popescu and I. Neamtu, “Possibilities for Poly(Aspartic Acid) Preparation as Biodegradable Compound,” Journal of Optoelectronics and Advanced Materials, Vol. 8, No. 2, 2006, pp. 663-666.

[15]   L. X. Song, C. F. Teng, P. Xu, H. M. Wang, Z. Q. Zhang and Q. Q. Liu, “Thermal Decomposition Behaviors of β-Cyclodextrin, Its Inclusion Complexes of Alkyl Amines, and Complexed β-Cyclodextrin at Different Heating Rates,” Journal of Inclusion Phenomena and Macrocyclic Chemistry, Vol. 60, No. 3-4, 2008, pp. 223-233.

[16]   J. F. R. Santos, R. Couceiro, A. Concheiro, J. J. T. Labandeira and C. Alvarez-Lorenzo, “Poly(Hydroxyethyl Methacrylate-Co-Methacrylated-β-Cyclodextrin) Hydrogels: Synthesis, Cytocompatibility, Mechanical Properties and Drug Loading/Release Properties,” Acta Biomaterialia, Vol. 4, No. 3, 2008, pp. 745-755.

[17]   Z. Wu, O. Tao, W. Cheng, L. Yu, X. Shi and Y. Qiao, “Visualizing Excipient Composition and Homogeneity of Compound Liquorice Tablets by Near-Infrared Chemical Imaging,” Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, Vol. 86, 2012, pp. 631-636.

[18]   C. C. Lin and A. T. Metters, “Hydrogels in Controlled Release Formulations: Network Design and Mathematical Modeling,” Drug Delivery Reviews, Vol. 58, No. 12-13, 2006, pp. 1379-1408.