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 AJAC  Vol.2 No.1 , February 2011
A New Potentiometric Sensor for Determination of Pethidine hydrochloride in Ampoules and Urine
Abstract: A simple, precise, rapid and low-cost potentiometric method for pethidine determination in pharmaceuticals and urine is proposed. A chemically modified carbon paste electrode (CMCPE) for pethidine hydrochloride (PDCl) based on pethidine-phosphotungstate (PD-PT) as ion-pair complex was prepared and fully character-ized in terms of composition, usable pH range, response time and temperature. The pethidine electrode showed Nernstain responses in the concentration range 2.1 × 10–6-1.0 × 10–2 M with a detection limit of 7.3 × 10-7 and usable within the pH range 3.5-6.6. This sensor exhibited a fast response time (about 5-8 s), good stability. The value (dE/dt) of the electrode was found to be 0.00071 V/?C, which indicates fairly high ther-mal stability. Selectivity coefficients determined by matched potential method (MPM) and separate solution method (SSM) showed high selectivity for PDCl with respect to a large number of inorganic cations, organic cations, sugars and some common drug excipients. The sensor could be used successfully in the estimation of PDCl in ampoules and in spiked urine samples.
Cite this paper: nullH. Abu-Shawish, N. Ghalwa, G. Khraish and J. Hammad, "A New Potentiometric Sensor for Determination of Pethidine hydrochloride in Ampoules and Urine," American Journal of Analytical Chemistry, Vol. 2 No. 1, 2011, pp. 56-65. doi: 10.4236/ajac.2011.21006.
References

[1]   S. White and S. H. Y. Wong, “Guidelines for Therapeutic Drug Monitoring Services,” In: A. Warner and T. Annesley, Eds., The National Academy of Clinical Biochemistry, Washington, 1999, pp. 63-73.

[2]   P. A. Greenwood, C. Merrin, T. McCreedy and G. M. Greenway, “Chemiluminescence μTAS for the Determination of Atropine and Pethidine,” Talanta, Vol. 56, No. 3, 2002, pp. 539-545.

[3]   B. Han, Y. Du and E. Wang, “Simultaneous Determination of Pethidine and Methadone by Capillary Electrophoresis with Electrochemiluminescence Detection of Tris(2,2’-bipyridyl)ruthenium(II),” Microchemical Journal, Vol. 89, No. 2, 2008, pp. 137-141.

[4]   T. G. Venkateshwaran, J. T. Stewart and D. T. King, “HPLC Determination of Morphine-Ondansetron and Meperidine-Ondansetron Mixture in 0.9% Sodium Chloride Injection,” Journal of Liquid Chromatography & Related Technologies, Vol. 19, No. 8, 1996, pp. 1329-1338.

[5]   C. R. Meatherall, D. R. P. Guay and R. P. Dvid, “Analysis of Meperidine and Normeperidine in Serum and Urine by High-Performance Liquid Chromatography,” Journal of Liquid Chromatography, Vol. 338, 1985, pp. 141-149.

[6]   S. W. Myung, S. Kim, J. H. Park, M. Kim, J. C. Lee and T. J. Kim, “Solid-Phase Microextraction for the Determination of Pethidine and Methadone in Human Urine Using Gas Chromatography with Nitrogen-Phosphorus Detection,” Analyst, Vol. 124, No. 9, 1999, pp. 1283-1286.

[7]   F. Liu, X. Y. Hu and Y. Luo, “Investigation of Meperidine and Its Metabolites in Urine of an Addict by Gas Chromatography-Flameionization Detection And Gas Chromatography-Mass Spectrometry,” Journal of Chromatography B: Biomedical Sciences and Applications, Vol. 658, 1994, pp. 375-379.

[8]   A. Ishii, M. Tanaka, R. Kurihara, K. Watanabe-Suzuki, T. Kumazawa, H. Seno, O. Suzuki and Y. Katsumata, “Sensitive Determination of Pethidine in Body Fluids by Gas Chromatography-Tandem Mass Spectrometry,” Journal of Chromatography B, Vol. 792, 2003, pp. 117-121.

[9]   H. Farsam and M. R. Nadjari-Moghaddam, “Spectrophotometric Determination of Meperidine Hydrochloride in Pharmaceutical Preparations by Complexation with Bromocresol Green,” Journal of Pharmaceutical and Biomedical Analysis, Vol. 2, 1984, pp. 543-547

[10]   A. Shalaby, M. El-Tohamy, M. El-Maamly and H. Y. Aboul-Enein, “Potentiometric Membrane Sensor for the Selective Determination of Pethidine in Pharmaceutical Preparations and Biological Fluids,” Annali di Chimica, Vol. 97, No. 10, 2007, pp. 1065-1074.

[11]   Z. H. Liu, M. L. Wen and J. Xiong, “A Pethidine Selective Polymeric Membrane Electrode Based on Pethidine- Silicotungstate,” Analytical Sciences, Vol. 16, No. 8, 2000, pp. 885-887.

[12]   Z. H. Liu, M. L. Wen and J. Xiong, “Plastic Membrane Electrode for the Potentiometric Determination of Pethi- Dine Hydrochloride in Pharmaceutical Preparations,” Fresenius Journal of Analytical Chemistry, Vol. 368, No. 4, 2000, pp. 335-337.

[13]   Z. H. Liu, M. L. Wen, Y. Yao and J. Xiong, “Plastic Pethidine Hydrochloride Membrane Sensor and Its Pharmaceutical Applications,” Sensors and Actuators B, Vol. 72, 2001, pp. 219-223.

[14]   Z. H. Liu, M. L. Wen, Y. Yao and J. Xiong, “A Pethidine Selective Polymeric Membrane Electrode,” Boletin de la Sociedad Chilena de Quimica, Vol. 47, No. 2, 2002, pp. 163-168.

[15]   H. Ibrahim, Y. M. Issa and H. M. Abu-Shawish, “Chemically Modified Carbon Paste Electrode of Dicyclomine Hydrochloride in Batch and in FIA Conditions,” Analytical Sciences, Vol. 20, No. 5, 2004, pp. 911-916.

[16]   A. O. Santini, H. R. Pezza, J. E. de Oliveira and L. Pezza, “Development of a Potentiometric Flufenamate ISE and its Application to Pharmaceutical and Clinical Analyses,” Journal of the Brazilian Chemical Society, Vol. 19, No. 1, 2008. pp. 162-168.

[17]   Y. M. Issa, H. Ibrahim and H. M. Abu-Shawish, “Carbon Paste Electrode for the Potentiometric Flow Injection Analysis of Drotaverine Hydrochloride in Serum and Urine,” Microchim Acta, Vol. 150, No. 1, 2005, pp. 47-54.

[18]   H. M. Abu-Shawish, “Potentiometric Response of Modified Carbon Paste Electrode Based on Mixed Ion-Ex- changers,” Electroanalysis, Vol. 20, No. 5, 2008, pp. 491-497.

[19]   H. Ibrahim, Y. M. Issa and H. M. Abu-Shawish, “Potentiometric Flow Injection Analysis of Mebeverine Hydrochloride in Serum and Urine,” Journal of Pharmaceutical and Biomedical Analysis, Vol. 36, No. 5, 2005, pp. 1053-1061.

[20]   G. A. E. Mostafa, “Development and Characterization of Ion Selective Electrode for the Assay of Antimony,” Talanta, Vol. 71, No. 4, 2007, pp. 1449-1454.

[21]   H. Ibrahim, Y. M. Issa and H. M. Abu-Shawish, “Potentiometric Flow Injection Analysis of Dicyclomine Hydrochloride in Serum, Urine and Milk,” Analytica Chimica Acta, Vol. 532, No. 1, 2005, pp. 79-88.

[22]   V. S. Bhat, V. S. Ijeri and K. A. Srivastava, “Coated Wire Lead(II) Selective Potentiometric Sensor Based on 4-tert- butylcalix[6]arene,” Sensors and Actuators B, Vol. 99, No. 1, 2004, pp. 98-105.

[23]   H. M. Abu-Shawish, S. M. Saadeh, K. Hartani and H. M. Dalloul, “A Comparative Study of Chromium(III) Ion- Selective Electrodes Based on N,N-Bis(salicylidene)-o- phenylenediaminatechromium(III),” Journal of the Iranian Chemical Society, Vol. 6, No. 4, 2009, pp. 729-737.

[24]   M. Arvand and S. A. Asadollahzadeh, “Ion-Selective Electrode for Aluminum Determination in Pharmaceutical Substances, Tea Leaves and Water Samples,” Talanta, Vol. 75, No. 4, 2008, pp. 1046-1054.

[25]   M. Shamsipur, M. Yousefi, M. Hosseini and M. R. Ganjali, “Lanthanum(III) PVC Membrane Electrodes Based on 1,3,5-trithiacyclohexane,” Analytical Chemistry, Vol. 74, No. 21, 2002, pp. 5538-5543.

[26]   E. A. Cummings, P. Mailley, S. Linquette-Mailley, B. R. Eggins, E. T. McAdams and S. McFadden, “Amperometric Carbon Paste Biosensor Based on Plant Tissue for the Determination of Total Flavanol Content in Beers,” Analyst, Vol. 123, No. 10, 1998, pp. 1975-1980.

[27]   J. S′anchez and M. Valle, “Determination of Anionic Surfactants Employing Potentiometric Sensors-A review,” Critical Reviews in Analytical Chemistry, Vol. 35, No. 1, 2005, pp. 15-29.

[28]   X. B. Zhang, Z. X. Han, Z. H. Fang, G. L. Shen and R. Q. Yu, “5,10,15-Tris(pentafluorophenyl)corrole as Highly Selective Neutral Carrier for a Silver Ion-Sensitive Electrode,” Analytica Chimica Acta, Vol. 562, No. 2, 2006, pp. 210-215.

[29]   P. R. Buck and E. Lindner, “IUPAC Recommendation for Nomenclature of Ion-Selective Electrodes,” Pure and Applied Chemistry, Vol. 66, No. 12, 1994, pp. 2527-2536.

[30]   H. M. Abu-Shawish, S. M. Saadeh and A. R. Hussien, “Enhanced Sensitivity for Cu(II) by a Salicylidine-Functionalized Polysiloxane Carbon Paste Electrode,” Talanta, Vol. 76, No. 3, 2008, pp. 941-948.

[31]   H. M. Abu-Shawish, “A Mercury(II) Selective Sensor based on N,N’-bis(salicylaldehyde)-phenylenediamine as Neutral Carrier for Potentiometric Analysis in Water Samples,” Journal of Hazardous Materials, Vol. 167, No. 1-3, 2009, pp. 602-608.

[32]   Y. Umezawa, P. Buhlmann, K. Umezawa, K. Tohda and S. Amemiya, “Potentiometric Selectivity Coefficients of Ion-Selective Electrodes,” Pure and Applied Chemistry, Vol. 72, No. 10, 2000, pp. 1851-2082.

[33]   S. Chandra, H. Agarwal and C.K. Singh, “A highly Selective and Sensitive Thorium(IV) PVC Membrane Electrode Based on a Dithio-Tetraaza Macrocyclic Compound,” Analytical Sciences, Vol. 23, No. 4, 2007, pp. 469-473.

[34]   H. X. Wang and M. Pu, “A Method of Determining Selectivity Coefficients Based on the Practical Slope of Ion Selective Electrodes,” Chinese Chemical Letters, Vol. 13, No. 4, 2002, pp. 355-358.

[35]   M. Arvand, M. Vejdani and M. Moghimi, “Construction and Performance Characterization of an Ion Selective Electrode for Potentiometric Determination of Atenolol in Pharmaceutical Preparations,” Desalination, Vol. 225, No. 1-3, 2008, pp. 176-184.

 
 
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