IJOHNS  Vol.2 No.5 , September 2013
The Presenting Symptom of Metastatic Prostate Carcinoma: Case of a Large Supraclavicular Mass and Review of Literature
Abstract: Prostate cancer is the most common noncutaneous malignancy of American males and typically presents with genitourinary symptoms, however, head and neck extension is a rare finding. We present a case of a 53-year-old male initially presenting with a large supraclavicular mass as the only complaint. After an initial non-diagnostic FNA biopsy, PSA levels, histology and immunohistochemical findings were consistent with metastatic prostatic adenocarcinoma. The patient was started on anti-hormonal treatment after diagnosis. Due to the increasing reports of such cases, we suggest PSA levels and appropriate immunohistochemical staining should be obtained on all unknown neck masses.
Cite this paper: C. Vaughn, K. Jaqua, R. Meacham and F. Vieira, "The Presenting Symptom of Metastatic Prostate Carcinoma: Case of a Large Supraclavicular Mass and Review of Literature," International Journal of Otolaryngology and Head & Neck Surgery, Vol. 2 No. 5, 2013, pp. 207-210. doi: 10.4236/ijohns.2013.25043.

[1]   A. J. Wein, L. R. Kavoussi, A. C. Novick, A. W. Partin and C. A. Peters, “Campbell-Walsh Urology,” 10th Edition, Elsevier Inc., Philadelphia, 2012, pp. 2704-2725.

[2]   American Cancer Society, “Cancer Facts & Figures 2008,” American Cancer Society, Atlanta, 2008.

[3]   R. H. Flocks and D. L. Boatman, “Incidence of Head and Neck Metastases from Genitor-Urinary Neoplasms,” Laryngoscope, Vol. 83, 1973, pp. 1527-1539. doi:10.1288/00005537-197309000-00011

[4]   K. R. Cho and J. I. Epstein, “Metastatic Prostate Carcinoma to Supradiaphragmtic Lymph Nodes. A Clinicopathologic and Immunohistochemical Study,” American Journal of Surgical Pathology, Vol. 11, No. 6, 1987, pp. 457-463. doi:10.1097/00000478-198706000-00006

[5]   B. Copeland, J. M. Clark, A. Sura, S. E. Kilpatrick, W. Shockley and S. Meredith, “Prostate Carcinoma Metastatic to the Cervical Lymph Nodes: Report of Two Cases and Review of the Literature,” American Journal of Otolaryngology, Vol. 22, No. 6, 2001, pp. 420-423. doi:10.1053/ajot.2001.28066

[6]   W. T. Couldwell, P. T. Chandrasoma and M. H. Weiss, “Pituitary Gland Metastasis from Adenocarcinoma of the Prostate. Case Report,” Journal of Neurosurgery, Vol. 71, No. 1, 1989, pp. 138-140. doi:10.3171/jns.1989.71.1.0138

[7]   G. Saeter, S. D. Fossa, S. Ous, G. P. Blom and O. Kaalhus, “Carcinoma of the Prostate with Soft Tissue or Non-Regional Lymphatic Metastases at the Time of Diagnosis: A Review of 47 Cases,” British Journal of Urology, Vol. 56, 1984, pp. 385-390. doi:10.1111/j.1464-410X.1984.tb05827.x

[8]   J. J. Butler, C. Howe and D. Johnson, “Enlargement of Supraclavicular Lymph Nodes as the Initial Sign of Prostate Carcinoma,” Cancer, Vol. 27, 1971, pp. 1055-1063. doi:10.1002/1097-0142(197105)27:5<1055::AID-CNCR2820270509>3.0.CO;2-T

[9]   H. Saitoh, M. Hida, T. Shimbo, et al., “Metastatic Patterns of Prostatic Cancer,” Cancer, Vol. 54, No. 12, 1984, pp. 3078-3084. doi:10.1002/1097-0142(19841215)54:12<3078::AID-CNCR2820541245>3.0.CO;2-U

[10]   M. Elkin and H. P. Mueller, “Metastases from Cancer of the Prostate,” Cancer, Vol. 7, No. 6, 1954, pp. 1246-1248. doi:10.1002/1097-0142(195411)7:6<1246::AID-CNCR2820070616>3.0.CO;2-C

[11]   H. L. Abrams, R. Sprio and N. Goldstein, “Metastases in carcinoma,” Cancer, Vol. 3, No. 1, 1950, pp. 74-85. doi:10.1002/1097-0142(1950)3:1<74::AID-CNCR2820030111>3.0.CO;2-7

[12]   E. R. Mintz and G. G. Smith, “Autopsy Findings in 100 Cases of Prostate Cancer,” New England Journal of Medicine, Vol. 211, 1934, pp. 479-487. doi:10.1056/NEJM193409132111101

[13]   J. L. Hunt, J. E. Tomaszewski and K. T. Montone, “Prostatic Adenocarcinoma Metastatic to the Head and Neck and the Workup of an Unknown Epithelioid Neoplasm,” Head & Neck, Vol. 26, No. 2, 2004, pp. 171-178. doi:10.1002/hed.10353

[14]   H. Jones and P. P. Anthony, “Metastatic Prostatic Carcinoma Presenting as Left-Sided Cervical Lymphadenopath: A Series of 11 Cases,” Histopathology, Vol. 21, No. 2, 1992, pp. 149-154. doi:10.1111/j.1365-2559.1992.tb00363.x

[15]   P. G. McMenamin, J. D. Anderson and J. J. Baker, “Prostatic Carcinoma Presenting in Neck Metastasis,” Journal of Otolaryngology, Vol. 3, 1989, pp. 119-124.

[16]   P. A. Humphrey, “Diagnosis of Adenocarcinoma in Prostate Needle Biopsy Tissue,” Journal of Clinical Pathology, Vol. 60, No. l, 2007, pp. 35-42. doi:10.1136/jcp.2005.036442

[17]   T. Sheridan, M. Herawi, J. I. Epstein and P. B. Illei, “The Role of P501S and PSA in the Diagnosis of Metastatic Adenocarcinoma of the Prostate,” American Journal of Surgical Pathology, Vol. 31, No. 9, 2007, pp. 1351-1355. doi:10.1097/PAS.0b013e3180536678

[18]   M. Yin, R. Dhir and A. V. Parwani, “Diagnostic Utility of p501s (Prostein) in Comparison to Prostate Specific Antigen (PSA) for the Detection of Metastatic Prostatic Adenocarcinoma,” Diagnostic Pathology, Vol. 27, No. 2, 2007, p. 41.