WJCS  Vol.3 No.5 , September 2013
Trimetazidine and Cellular Response in Cardiopulmonary Bypass*
ABSTRACT
Background: Organic cellular inflammatory response constitutes a pathophysiological mechanism present in all Coronary Artery Bypass Graftings (CABGs). In this aspect, the organism brings forth its defenses through answers that involve cellular components. Objectives: To evaluate, in a randomized double-blind prospective study, controlled with placebo, the effects of trimetazidine (Tmz) on cellular response, analyzed through the variation of leukocytes, neutrophils and monocytes. Patients and Method: 30 patients were randomly selected to be studied, with no more than a mild ventricular dysfunction, and divided into two groups (Tmz and placebo) stratified by echocardiography and receiving medication/placebo in a 60 mg/day dose. The samples of leukocytes, neutrophils and monocytes were obtained in the pre-operatory day without medication, at surgery day with 12 to 15 days of medication/placebo, with 5 minutes after the aortic declamping, and within 12, 24 and 48 hours after surgery. Results: The leukocytes and neutrophils levels have decreased significantly in the treated group when compared to the control group, in all analyzed moments (p = 0.012; p = 0.005). Conclusions and Clinical Implications: Trimetazidine has proved to reduce significantly the levels of total leukocytes and neutrophils in patients submitted to CABG.

Cite this paper
G. Martins, A. G. de Siqueira Filho, J. Bosco de F. Santos, C. Roberto Cavalcanti Assunção, A. Valência and G. Martins, "Trimetazidine and Cellular Response in Cardiopulmonary Bypass*," World Journal of Cardiovascular Surgery, Vol. 3 No. 5, 2013, pp. 171-179. doi: 10.4236/wjcs.2013.35035.
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