A simple and rapid Supercritical Fluid Chromatography (SFC) method
has been developed to isolate and characterize R-Isomer of Ezetimi be by
using normal phase Chiral Cel OD-H with
 M. Von Heek, C. Farley and D. S. Compton, “Ezetimibe Selectively Inhibits Intestinal Cholesterol Absorption in Rodents in Presence and Absence of Exocrine Pancreatic Function,” British Journal of Pharmacology, Vol. 134, No. 2, 2001, pp. 409-417.
 S. Singh, B. Singh, R. Bahuguna, L. Wadhwa and R. Saxena, “Stress Degradation Studies on Ezetimibe and Development of a Validated Stability-Indicating HPLC Assay,” Journal of Pharmaceutical and Biomedical Analysis, Vol. 41, No. 3, 2006, pp. 1037-1040. doi:10.1016/j.jpba.2006.01.030
 R. Sistla, V. S. Tata, Y. V. Kashyap, D. Chandrasekar and P. V. Diwan, “Development and Validation of a Reversed-Phase HPLC Method for the Determination of Ezetimibe in Pharmaceutical Dosage Forms,” Journal of Pharmaceutical and Biomedical Analysis, Vol. 39, No. 3-4, 2005, pp. 517-522. doi:10.1016/j.jpba.2005.04.026