Introduction: This article is a case report of metastatic
malignant melanoma to the ovary and a review of the current literature on
recommendations for diagnosis and management. Background: Metastatic
involvement of the ovary from malignant melanoma is relatively uncommon and represents
a diagnostic challenge. There are 74 cases of malignant melanoma metastasing to
the ovary reported in the English literature. Malignant melanoma in the ovary
is often found at autopsy, as a part of an extensive multisystemic spread of
the disease and is rarely diagnosed during life. Most cases reported in the
literature thus far occurred in women of reproductive age. Commonly, the
history of a primary cutaneous melanoma lesion is remote, and in some cases,
absent . Most cases are associated with disseminated disease and carried a
dismal prognosis .
Cite this paper
Harris, A. and Blumenthal, N. (2013) Metastatic malignant melanoma arising in the ovary: A case report and review of the literature. Open Journal of Obstetrics and Gynecology, 3, 7-9. doi: 10.4236/ojog.2013.37A1002.
 Gupta, D., Deavers, D., Silva, E. and Malpica. A. (2004) Malignant melanoma involving the ovary: A clinicopathologic and immunohistochemichal study of 23 cases. The American Journal of Surgical Pathology, 28, 771-780. doi:10.1097/01.pas.0000126786.69232.55
 Boustis, A., Valeri, R., Korantzis, I., et al. (2008) Delayed malignant melanoma recurrence stimulating primary ovarian cancer: Case report. World Journal of Surgical Oncology, 6, 124-129.
 Moore, R., Chung, M., Granai. C., Gajewski, W. and Steinhoff, M. (2004) Incidence of metastasis to the ovaries fronnongenital tract primary tumors. Gynecologic Oncology, 93, 87-91. doi:10.1016/ j.ygyno.2003.12.039
 Fuller, P. (1999) Malignant melanoma of the ovary and exposure to clomiphine citrate: A case report and review of the literature. American Journal of Obstetrics & Gynecology, 180, 1499-1503.
 Curtin, J.P. and Morrow, C.P. (1992) Melanoma of the female genital tract. In: Coppelson, M., Monaghan, J.M., Morrow, C.P. and Tattersall, M.H., Eds., Gynecologic Oncology, 2nd Edition, Churchill Livingstone, London, 9, 1059-1068.
 Young, P. (2007) From Krukenberg to today: The ever present problems posed by metastatic tumors in the ovary, Part II. Advances in Anatomic Pathology, 14, 149-177.
 Bishop, P.W., Menasce, L.P., Yates, A.J., Win, N.A. and Banerjee, S.S. (1993) An immunophenotypic survey of malignant melanomas. Histopathology, 23, 159-166.
doi:10.1111 /j.1365-2559. 1993.tb00474.x
 Moselhi, M., Spencer, J., and Lane, G. (1998) Malignant melanoma metastatic to the ovary: Presentation and radiological characteristics. Gynecologic Oncology, 69, 165-168. doi:10.1006/ gyno.1998.4992
 Banerjee, S.S. and Harris, M. (2000) Morphological and Immunophenotypic variations of malignant melanoma. Histopathology, 36, 387-402.