Pectin-Based Biodegradable Hydrogels with Potential Biomedical Applications as Drug Delivery Systems
Author(s)
Mohammad Sadeghi
ABSTRACT
In this work, synthesis and swelling behavior of a superabsorbent hydrogel based on Pectin (Pc) and polyacrylonitrile (PAN) were investigated. A mechanism for hydrogel formation was proposed and the structure of the product was es-tablished using FTIR spectroscopy. The Pc-poly (sodium acrylate-co-acrylamide) hydrogel exhibited a pH-responsive swelling-deswelling behavior at pH’s 2 and 8. This on-off switching behavior provides the hydrogel with the potential to control delivery of bioactive agents. Release profiles of ibuprofen (IBU), a poor water-soluble drug, from the hydro-gels were studied under both simulated gastric and intestinal pH conditions.
In this work, synthesis and swelling behavior of a superabsorbent hydrogel based on Pectin (Pc) and polyacrylonitrile (PAN) were investigated. A mechanism for hydrogel formation was proposed and the structure of the product was es-tablished using FTIR spectroscopy. The Pc-poly (sodium acrylate-co-acrylamide) hydrogel exhibited a pH-responsive swelling-deswelling behavior at pH’s 2 and 8. This on-off switching behavior provides the hydrogel with the potential to control delivery of bioactive agents. Release profiles of ibuprofen (IBU), a poor water-soluble drug, from the hydro-gels were studied under both simulated gastric and intestinal pH conditions.
Cite this paper
nullM. Sadeghi, "Pectin-Based Biodegradable Hydrogels with Potential Biomedical Applications as Drug Delivery Systems," Journal of Biomaterials and Nanobiotechnology, Vol. 2 No. 1, 2011, pp. 36-40. doi: 10.4236/jbnb.2011.21005.
nullM. Sadeghi, "Pectin-Based Biodegradable Hydrogels with Potential Biomedical Applications as Drug Delivery Systems," Journal of Biomaterials and Nanobiotechnology, Vol. 2 No. 1, 2011, pp. 36-40. doi: 10.4236/jbnb.2011.21005.
References
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[1] F. L. Buchholz and A. T. Graham “Modern Superabsorbent Polymer Technology,” Wiley, New York, 1997. [2] Po R. “Water-absorbent Polymers, A Patent Survey,” Journal of Macromolecular Science, Reviews in Macromolecular Chemistry & Physics, C34, 1994, pp. 607-661. [3] J. Kost, “Encyclopedia of Controlled Drug Delivery,” E. Mathiowitz, Ed. Wiley, New York, 1999. [4] A. S. Hoffman, “Polymeric Materials Encyclopedia,” J. C. Salamone; Ed., CRC Press, Boca Raton, FL. 5, 1996. [5] N. A. Peppas and A. G. Mikes, “Hydrogels in Medicine and Pharmacy,” CRC Press Inc., Boca Raton, Florida.1, 27(1986). [6] P. J. Flory, “Principles of polymer chemistry,” Ithaca, NY: Cornell University Press, 1953. [7] R. M. Silverstein and F. X. Webster, “Spectrometric Identification of Organic Compounds,” 6th Edition, Wiley: New York, 1998. [8] A. Pourjavadi, M. Sadeghi and H. Hosseinzadeh (2004). Polymers for Advanced Technologies, 15: pp. 645-653. [9] A. M. Lowman and N. A. Peppas, “Hydrogels”, In: E. Mathiowitz, Ed. Encyclopedia of Controlled Drug Delivery, Wiley, New York, 1999, p. 139. [10] Z. Mohamadnia, M. J. Zohuriaan-Mehr, K. Kabiri, A. Jamshidi and H. Mobedi, Journal of Bioactive and Compatible Polymers, Vol. 22, 2007, pp. 342. [11] L. H. Gan, G. R. Deen, Y. Y. Gan and K. C. Tam, European Polymer Journal, Vol. 37, 2001, pp. 1473-1478. [12] M. Mahkam, L. Doostie and S. O. R. Siadat (2006). Inflammo Pharmacology Vol. 14, 2006, pp. 72-75. [13] M. Mahkam and M. Allahverdipoor, Drug Targeting, Vol. 12, 2004, pp. 151-156.