ABSTRACT In this work, synthesis and swelling behavior of a superabsorbent hydrogel based on Pectin (Pc) and polyacrylonitrile (PAN) were investigated. A mechanism for hydrogel formation was proposed and the structure of the product was es-tablished using FTIR spectroscopy. The Pc-poly (sodium acrylate-co-acrylamide) hydrogel exhibited a pH-responsive swelling-deswelling behavior at pH’s 2 and 8. This on-off switching behavior provides the hydrogel with the potential to control delivery of bioactive agents. Release profiles of ibuprofen (IBU), a poor water-soluble drug, from the hydro-gels were studied under both simulated gastric and intestinal pH conditions.
Cite this paper
nullM. Sadeghi, "Pectin-Based Biodegradable Hydrogels with Potential Biomedical Applications as Drug Delivery Systems," Journal of Biomaterials and Nanobiotechnology, Vol. 2 No. 1, 2011, pp. 36-40. doi: 10.4236/jbnb.2011.21005.
 F. L. Buchholz and A. T. Graham “Modern Superabsorbent Polymer Technology,” Wiley, New York, 1997.
Po R. “Water-absorbent Polymers, A Patent Survey,” Journal of Macromolecular Science, Reviews in Macromolecular Chemistry & Physics, C34, 1994, pp. 607-661.
J. Kost, “Encyclopedia of Controlled Drug Delivery,” E. Mathiowitz, Ed. Wiley, New York, 1999.
A. S. Hoffman, “Polymeric Materials Encyclopedia,” J. C. Salamone; Ed., CRC Press, Boca Raton, FL. 5, 1996.
N. A. Peppas and A. G. Mikes, “Hydrogels in Medicine and Pharmacy,” CRC Press Inc., Boca Raton, Florida.1, 27(1986).
P. J. Flory, “Principles of polymer chemistry,” Ithaca, NY: Cornell University Press, 1953.
R. M. Silverstein and F. X. Webster, “Spectrometric Identification of Organic Compounds,” 6th Edition, Wiley: New York, 1998.
A. Pourjavadi, M. Sadeghi and H. Hosseinzadeh (2004). Polymers for Advanced Technologies, 15: pp. 645-653.
A. M. Lowman and N. A. Peppas, “Hydrogels”, In: E. Mathiowitz, Ed. Encyclopedia of Controlled Drug Delivery, Wiley, New York, 1999, p. 139.
Z. Mohamadnia, M. J. Zohuriaan-Mehr, K. Kabiri, A. Jamshidi and H. Mobedi, Journal of Bioactive and Compatible Polymers, Vol. 22, 2007, pp. 342.
L. H. Gan, G. R. Deen, Y. Y. Gan and K. C. Tam, European Polymer Journal, Vol. 37, 2001, pp. 1473-1478.
M. Mahkam, L. Doostie and S. O. R. Siadat (2006). Inflammo Pharmacology Vol. 14, 2006, pp. 72-75.
M. Mahkam and M. Allahverdipoor, Drug Targeting, Vol. 12, 2004, pp. 151-156.