with epithelian ovarian cancer who have achieved remission after initial
surgery and induction chemotherapy, the role of maintenance chemotherapy is
controversial. We carried out a trial-sequential analysis that included 4 randomised
controlled trials. The end-point was progression at 3 years while the boundary
for non-inferiority was set at ±20% in risk ratio. The results of our
trial-sequential analysis indicated the futility of maintenance chemotherapy, i.e. proof of no effectiveness.
Consequently, no further trials of this type should be performed to assess the
effectiveness of this intervention in this clinical condition.
Cite this paper
A. Messori, V. Fadda, D. Maratea and S. Trippoli, "Maintenance Chemotherapy in Ovarian Cancer: A Trial-Sequential Analysis," Journal of Cancer Therapy, Vol. 4 No. 7, 2013, pp. 1242-1243. doi: 10.4236/jct.2013.47145.
 L. Mei, H. Chen, D. M. Wei, F. Fang, G. J. Liu, H. Y. Xie, et al., “Maintenance Chemotherapy for Ovarian Cancer,” Cochrane Database Systematic Reviews, Vol. 6, 2013, Article ID: CD007414.
 J. Wetterslev, K. Thorlund, J. Brok and C. Gluud, “Trial Sequential Analysis May Establish When Firm Evidence Is Reached in Cumulative Meta-Analysis,” Journal of Clinical Epidemiology, Vol. 61, No. 1, 2008, pp. 64-75.
 J. Brok, K. Thorlund, C. Gluud and J. Wetterslev, “Trial Sequential Analysis Reveals Insufficient Information Size and Potentially False Positive Results in Many MetaAnalyses,” Journal of Clinical Epidemiology, Vol. 61, No. 8, 2008, pp. 763-769. doi:10.1016/j.jclinepi.2007.10.007
 A. Messori, V. Fadda, D. Maratea and S. Trippoli, “ω-3 Fatty Acid Supplements Form Secondary Prevention of Cardiovascular Disease: From No Proof of Effectiveness to Proof of No Effectiveness,” JAMA Internal Medicine, 2013, Epub.
 D. Maratea, V. Fadda, S. Trippoli and A. Messori, “OffPump versus On-Pump Coronary Artery Bypass Grafting: Quantifying Information Size by Trial Sequential Analysis,” European Journal of Internal Medicine, 2013, Epub.
 S. Pecorelli, G. Favalli, A. Gadducci, D. Katsaros, P. B. Panici, A. Carpi, et al., “Phase III Trial of Observation versus Six Courses of Paclitaxel in Patients with Advanced Epithelial Ovarian Cancer in Complete Response after Six Courses of Paclitaxel/Platinum-Based Chemotherapy: Final Results of the After-6 Protocol 1,” Journal of Clinical Oncology, Vol. 27, No. 28, 2009, pp. 4642-4648. doi:10.1200/JCO.2009.21.9691