OJST  Vol.3 No.6 , September 2013
A unique case of a calcifying cystic odontogenic tumor

The calcifying odontogenic cyst was first reported by Gorlin et al. in 1962. At that time, it was classified as a cyst related to the odontogenic apparatus, although it was later renamed as a calcifying cystic odontogenic tumor by the WHO calcification in 2005 due to its histological complexity, morphological diversity and aggressive proliferation [2]. Here, we describe a case of a calcifying cystic odontogenic tumor in a 4- year-old boy. The lesion was surgically removed, and the histopathological examination revealed it to be a cystic tumor with ghost cells, a stellate reticulum and small amount of dentinoid tissue in the cystic wall.

Cite this paper
Gamoh, S. , Nakashima, Y. , Akiyama, H. , Shimizutani, K. , Sanuki, T. , Kotani, J. , Yamada, K. , Morita, S. , Tominaga, K. , Wato, M. and Tanaka, A. (2013) A unique case of a calcifying cystic odontogenic tumor. Open Journal of Stomatology, 3, 314-317. doi: 10.4236/ojst.2013.36052.
[1]   Gorlin, R.J., Pindborg, J.J., Clausen, F.P. and Vickers, R.A. (1962) The calcifying odontogenic cyst—A possible analogue of the cutaneous calcifying epithelioma of Malherbe. An analysis of fifteen cases. Oral Surgery, Oral Medicine, Oral Pathology, 15, 1235-1243. doi:10.1016/0030-4220(62)90159-7

[2]   Praetorius, F. and Ledesma-Montes, C. (2005) Dentino- genic ghost cell tumour. In: Barnes, L., Eveson, J.W., Reichart, P. and Sidransky, D., Eds., World Health Organization Classification of Tumours. Pathology and Genetics of Head and Neck Tumours. IARC Press, Lyon, 314.

[3]   Chindasombatjaroen, J., Kakimoto, N., Akiyama, H., Ku- bo, K., Murakami, S., Furukawa, S. and Ki-shino, M. (2007) Computerized tomography observation of a calcifying cystic odontogenic tumor with an odontoma: Case report. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 104, e52-e57. doi:10.1016/j.tripleo.2007.06.025

[4]   Verbin, R. and Barned, L. (2001) Cysts and cyst-like lesions of the oral cavity, jaws and neck. In: Barnes, L., Ed., Surgical Pathology of the Head and Neck, Vol. 3, 2nd Edition, Marcel Decker, New York, 1437-1555.

[5]   Kamboj, M. and Juneja, M. (2007) Amelo-blastoma Gorlin’s cyst. Journal of Oral Science, 49, 319-323. doi:10.2334/josnusd.49.319

[6]   Ledesma-Montes, C., Gorlin, R.J., Shear, M., Prae Torius, F., Mosqueda-Taylor, A., Altini, M., et al. (2007) International collabolative study on ghost cell odontogenic tumours. Calcifying cystic odontogenic tumour, dentino- genic ghost cell tumour, and ghost cell odontogenic carcinoma. Journal of Oral Pathology & Medicine, 37, 302- 308.doi:10.1111/j.1600-0714.2007.00623.x

[7]   Sakai, V.T., Filho, C.E., Moretti, A.B., Pereira, A.A., Ha- nemann, J.A. and Duque, J.A. (2011) Conservative surgical treatment of an aggressive calcifying cystic odontogenic maxillary tumor in the young permanent dentition. Pediatric Dentistry, 33, 265-269.

[8]   Kler, S., Palaskar, S., Shetty, V.P. and Bhushan, A. (2009) Intraosseous calcifying cystic odontogenic tumor. Journal of Oral and Maxillofacial Pathology, 13, 27-29. doi:10.4103/0973-029X.48753

[9]   Marques, Y.M.F.S., Botelho, T.L., Xavier, F.C.A., Ran- gel, A.L., Rege, I.C.C. and Mantesso, A. (2010) Importance of cone beam computed tomography for diagnosis of calcifying cystic odontogenic tumor associated to odontoma. Report of a case, Medicina Oral Patologia Oral y Cirugia Bucal, 1, ed3, e490-e493.

[10]   Niikuni, T., Takigawa, T., Kawagoe, H., Ko-bayashi, A. and Yokoi, S. (1966) A clinical case of keratinizing and calcifying odontogenic epithelial tumor in the upper jaw. Journal of Nihon University School of Dentistry, 8, 116- 122. doi:10.2334/josnusd1959.8.116

[11]   Jones, J.H., McGowan, D.A. and Gorman, J.M. (1968) Calcifying epithelial odontogenic and keratinizing odon- togenic tumors. Oral Surgery, Oral Medicine, Oral Pathology, 25, 465-469. doi:10.1016/0030-4220(68)90022-4

[12]   Fejerskov, O. and Krogh, J. (1972) The calcifying ghost cell odontogenic tumor or the calcifying odontogenic cyst. Journal of Oral Pathology, 1, 273-287. doi:10.1111/j.1600-0714.1972.tb01666.x

[13]   Singhaniya, S.B., Barpande, S.R. and Bhavthanker, J.D. (2009) Dentinogenic ghost cell tumor. Journal of Oral and Maxillofacial Pathology, 13, 97-100. doi:10.4103/0973-029X.57679

[14]   Kumar, U., Vij, H., Vij, R., Kharbanda, J., Aparna, I.N. and Radhakrishman, R. (2010) Dentinogenic ghost cell tumor of the peripheral variant mimicking epulis. International Journal of Dentistry. doi:10.1155/2010/519494

[15]   Li, B.B. and Gao, Y. (2008) Ghost cell odontogenic carcinoma transformed from a dentinogenic ghost cell tumor of maxilla after multiple recurrences. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodo- ntology, 107, 691-695. doi:10.1016/j.tripleo.2009.01.008

[16]   Lombardi, T., Felice, R.D. and Samson, J. (1999) Epithelial odontogenic ghost cell tumour of the mandibular gingival. Oral Oncology, 35, 439-442.

[17]   Kim, H.J., Choi, S.K., Lee, C.J. and Suh, C.H. (2001) Aggressive epithelial odontogenic ghost cell tumor in the mandible: CT and MR imaging findings. American Journal of Neuroradiology, 22, 175-179.

[18]   Zornosa, X. and Muller, S. (2010) Calcifying cystic odontogenic tumor. Head & Neck Pathology, 4, 292-294. doi:10.1007/s12105-010-0197-z

[19]   Buchner, A. (1991) The central (intraosseous) calcifying odontogenic cyst: An analysis of 215 cases. Journal of Oral and Maxillofacial Surgery, 49, 330-339. doi:10.1016/0278-2391(91)90365-S

[20]   Soares, E.C.S., Costa, F.W.G., Neto, I.C.P., Bezerra, T.P., Patrocinio, R.M.S.V. and Alves, A.P.N.N. (2011) Rare hybrid odontogenic tumor in a 2-year-old child. Journal of Craniofacial Surgery, 22, 554-558. doi:10.1097/SCS.0b013e3182074616