We report a 9-year-old Japanese girl who presented
with muscle weakness and elevated serum levels of muscle-derived enzymes
following mycoplasma infection. Rhabdomyolysis or myositis was suggested by
magnetic resonance imaging and repeated four times within 4 years. Each episode
developed following respiratory infection and spontaneously recovered. The
diagnosis of Sjogren’s syndrome was made by decreased salivary secretion, MR
sialography, lip biopsy, and positive anti-SSA/Ro antibody. Given the rarity of
rhabdomyolysis/myositis, recurrent episode could be induced by infectious
disease on the basis of underlying Sjogren’s syndrome. Conclusion: Sjogren’s
syndrome should be considered as an underlying disease of recurrent
infection-induced rhabdomyolysis/ myositis.
Cite this paper
Morikawa, S. , Kobayashi, I. , Uzuki, Y. , Ueki, M. , Hattori, T. and Aoyagi, H. (2013) A case of recurrent rhabdomyolysis associated with childhood Sjögren’s syndrome. Open Journal of Pediatrics, 3, 276-278. doi: 10.4236/ojped.2013.33049.
 Perreault, S., Birca, A., Piper, D., Nadeau, A., Gauvin, F. and Vanasse, M. (2011) Transient creatine phosphokinase elevation in children: A single-center experience. Journal of Pediatrics, 59, 682-685.
 Anaya, J.M., Ogawa, N. and Talal, N. (1995) Sjogren’s syndrome in childhood. The Journal of Rheumatology, 22, 1152-1158.
 Kobayashi, I., Furuta, H., Tame, A., Kawamura, N., Kojima, K., Endoh, M., Okano, M. and Sakiyama, Y. (1996) Complications of childhood Sj?gren’s syndrome. European Journal of Pediatrics, 155, 890-894.
 Aoki, A., Ono, S., Ueda, A., Hagiwara, E., Tsuji, T., Misumi, M., Ideguchi, H., Takeda, Y. and Ishigatsubo, Y. (2003) Myositis in primary Sj?gren’s syndrome: Clinical and pathological report. Modern Rheumatology, 13, 57-61. doi:10.1007/s101650300008
 Kraus, A., Cifuentes, M., Villa, A.R., Jakez, J., Reyes, E. and Alarcón-Segovia, D. (1994) Myositis in primary Sjogren’s syndrome. Report on three cases. The Journal of Rheumatology, 21, 649-653.
 Lindvall, B., Bengtsson, A., Ernerudh, J. and Eriksson, P. (2002) Subclinical myositis is common in primary Sjogren’s syndrome and is not related to muscle pain. The Journal of Rheumatology, 29, 717-725.
 Vitali, C., Bombardieri, S., Jonsson, R., Moutsopoulos, H.M., Alexander, E.L., Carsons, S.E., Daniels, T.E., Fox, P.C., Fox, R.I., Kassan, S.S., Pillemer, S.R., Talal, N. and Weisman, M.H. (2002) Classification criteria for Sjogren’s syndrome: A revised version of the European criteria proposed by the American-European Consensus Group. Annals of the Rheumatic Diseases, 61, 554-558. doi:10. 1136/ard.61.6.554
 Khan, F.Y. (2009) Rhabdomyolysis: A review of the literature. The Netherlands Journal of Medicine, 67, 272-283.
 Kobayashi, I., Ono, S., Kawamura, N., Okano, M. and Kobayashi, K. (2001) Elevated serum levels of soluble interleukin 2 receptor in juvenile dermatomyositis. Pediatrics International, 43, 109-111.
 Berger, R.P. and Wadowsky, R.M. (2000) Rhabdomyolysis associated with infection by mycoplasma pneumonia: A case report. Pediatrics, 5, 433-436.