CRCM  Vol.2 No.6 , September 2013
Fever of unknown origin as the first manifestation of Erdheim-Chester disease
ABSTRACT
Erdheim-Chester disease (ECD) is an uncommon non-Langerhans cell histiocytosis that affects multiple body systems and can present clinically in a myriad of ways. We report the case of a 29-year-old man presented with fever and diffuse bone pain. Physical examination showed bilateral and symmetrical long bone pain, especially the knees. Radiographs showed multiple mixed bone lesions with sclerotic and lytic areas of the femora, tibiae, and fibula. Biopsy of the tibial area displayed foamy lipid-laden histiocytes, confirming the diagnosis of ECD.

Cite this paper
Li, N. , Chen, M. , Sun, H. , Bao, Y. and Zhang, J. (2013) Fever of unknown origin as the first manifestation of Erdheim-Chester disease. Case Reports in Clinical Medicine, 2, 351-357. doi: 10.4236/crcm.2013.26095.
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