Twenty two haplotypes were generated from a pool of 60 unrelated Saudi β thalassemia major patients using previously described restriction sites in the β globin gene. Linkage disequilibrium analysis of the polymorphic sites was also conducted, a few identified haplotypes were novel while the remainder was previously reported, haplotype1222212 was the most frequent haplotype in the study group and a strong linkage disequilibrium between two polymorphic restriction sites in these β thalassemia patients was uncovered.
 Pirastu, M., Galanello, R., Doherty, M.A., Tuveri, T., Cao, A. and Kan, Y.W. (1987) The same beta-globin gene mutation is present on nine different beta-thalassemia chromosomes in a Sardinian population. The Proceedings of the National Academy of Sciences of the United States of America, 84, 2882-2885. doi:10.1073/pnas.84.9.2882
 Orkin, S.H., Kazazian Jr., H.H., Antonarakis, S.E., Goff, S.C., Boehm, C.D., Sexton, J.P., Waber, P.G. and Giardina, P.J. (1982) Linkage of beta-thalassaemia mutations and beta-globin gene polymorphisms with DNA polymerphisms in human beta-globin gene cluster. Nature, 296, 627-631. doi:10.1038/296627a0
 Long, J.C., Chakravarti, A., Boehm, C.D., Antonarakis, S. and Kazazian, H.H. (1990) Phylogeny of human betaglobin haplotypes and its implications for recent human evolution. American Journal of Physical Anthropology, 81, 113-130. doi:10.1002/ajpa.1330810112
 Kazazian, H.H. Jr., Orkin, S.H., Antonarakis, S.E., Sexton, J.P., Boehm, C.D., Goff, S.C. and Waber, P.G. (1984) Molecular characterization of seven beta-thalassemia mutations in Asian Indians. EMBO Journal, 3, 593-596.