WJCD  Vol.3 No.5 , August 2013
Magnetocardiography capabilities in myocardium injuries diagnosis
Abstract: Objective: The electrophysiological properties of the myocardium are extremely heterogeneous. Verification of new magnetocardiography (MCG) signs appears an important aspect for severity assessment of ischemic myocardium damage, ischemic heart disease (IHD) course prognosis, determining of indications for preventive “aggressive” therapy and estimation of its efficacy in patients with IHD. The objective of this research was the investigation of magnetocardiography (MCG) capabilities in diagnosis of ischemic and inflammatory myocardial injuries using new MCG markers of the spatiotemporal organization of myocardium excitation. Methods and results: There were 128 patients examined in three groups. Group 1 contained 34 healthy volunteers. Group 2 contained 62 patients with IHD diagnosis. Group 3 included 32 comparatively young patients with acute myocarditis diagnosis. MCG-mapping of patients was performed at rest on the 7-channel MCG-scanners “Cardiomagscan” V 3.1 (Company KMG, Ukraine) in non-shielded MCG laboratory. 11 MCG markers were determined for selected time intervals of the cardiac cycle. Obtained data provided evidences about significant differences in values of proposed MCG markers for various groups. In patients with AMI, rate of parameters change is higher than without AMI (Sub-groups 2.1 and 2.2 differ by 8 MCG markers). Patients of 2nd and 3rd groups are different from healthy patients by 8 of 11 markers. Analysis of the obtained data has demonstrated good capabilities of MCG in differential diagnostics. Application of discriminatory analysis allowed us to get classification functions, which could be used (with 82% accuracy) to qualify the just examined patient to the investigated categories. Conclusion: Based on the new methodological approach during the studies, the most informative MCG-criteria of space-temporal organization of myocardium excitation in patients with IHD has been proposed. The method is able to distinguish healthy subjects and myocarditis patients and patients with IHD without previous MI with high sensitivity and specificity.
Cite this paper: Sosnytskyy, V. , Chaikovsky, I. , Stadnyuk, L. , Miasnykov, G. , Kazmirchyk, A. , Sosnytska, T. and Gurjeva, O. (2013) Magnetocardiography capabilities in myocardium injuries diagnosis. World Journal of Cardiovascular Diseases, 3, 380-388. doi: 10.4236/wjcd.2013.35059.

[1]   Kemp, H.G., Kronmal, R.A., Vietstra, R.E. and Frye, R.L. (1986) Seven year survival of patients with normal coronary arteriograms: A CASS registry study. Journal of the American College of Cardiology, 7, 479-483. doi:10.1016/S0735-1097(86)80456-9

[2]   Malmivuo, J. and Plonsey, R. (1995) Bioelectromagnetism: Principles and applications of bioelectric and biomagnetic fields. New York: Oxford University Press. doi:10.1093/acprof:oso/9780195058239.001.0001

[3]   Stroink, G., Moshage, W. and Achenbach, S. (1998) Cardiomagnetism. In: Andr. W. and Nowak, H., Eds., Magnetism in Medicine, Wiley-VCH, Berlin, 136-189.

[4]   Tavarozzi, I., Comani, S., Del Gratta, C., Di Luzio, S., Romani, G.L., Gallina, S., et al. (2002) Magneto-cardiography: Current status and perspectives. Part II: Clinical applications. Italian Heart Journal, 3, 151-165.

[5]   Fenici, R., Brisinda, D. and Meloni, A.M. (2005) Clinical application of magnetocardiography. Expert Review of Molecular Diagnostics, 5, 291-313. doi:10.1586/14737159.5.3.291

[6]   Van Leeuwen, P., Hailer, B., Lange, S. and Grцnemeyer, D. (2003) Spatial distribution of repolarization times in patients with coronary artery disease. Pacing and Clinical Electrophysiology, 26, 1706-1714. doi:10.1046/j.1460-9592.2003.t01-1-00256.x

[7]   Hailer, B., Chaikovsky, I., Auth-Eisernitz, S., Schafer, H. and Van Leeuwen, P. (2005) The value of magnetocardiography in patients with and without relevant stenoses of the coronary arteries using an unshielded system. Pacing and Clinical Electrophysiology, 28, 8-11. doi:10.1111/j.1540-8159.2005.09318.x

[8]   Park, J.W., Hill, P.M., Chung, N., Hugenholtz, P.G. and Jung, F. (2005) Magnetocardiography predicts coronary artery disease in patients with acute chest pain. Annals of Noninvasive Electrocardiology, 10, 312-323. doi:10.1111/j.1542-474X.2005.00634.x

[9]   Tolstrup, K., Madsen, B.E., Ruiz, J.A., Greenwood, S.D, Camacho, J., Siegel, R.J., et al. (2006) Non-invasive resting magnetocardiographic imaging for the rapid detection of ischemia in subjects presenting with chest pain. Cardiology, 106, 270-276. doi:10.1159/000093490

[10]   Chen, Y. (2005) Resting magnetocardiographic imaging can accurately detect obstructive coronary artery disease in patient with chronic ischaemia. Journal of the American College of Cardiology, 45, 27-69.

[11]   Park, J.W. et al. (2005) Magnetocardiography predicts coronary artery disease in bundle brunch block patients with acute chest pain. Journal of Electrocardiology, 40, S53.

[12]   Van de Werf, F., Ardissino, D., Betriu, A. et al. (2003) Management of acute myocardial infarction in patients presenting with ST-segment elevation: The task force on the management of acute myocardial infarction of the european society of cardiology. European Heart Journal, 24, 28-66. doi:10.1016/S0195-668X(02)00618-8

[13]   Sosnytskyy, V.M., Vojtovich, I.D., Bojchak, M.P., Myasnikov, G.V., Chaikovsky, I.A. and Sosnitskaya, T.V. (2011) Magnetic mapping of the heart-new information technology of noninvasive electrophysiology. Reports of the National Academy of Sciences of Ukraine, 1, 166-171.

[14]   Ertl, G. and Frantz, S. (2005) Healing after myocardial infarction. Cardiovascular Research, 66, 22-32, doi:10.1016/j.cardiores.2005.01.011

[15]   Casolo G., Minneci S., Manta R., et al. (2006) Identification of the ischemic etiology of heart failure by cardiovascular magnetic resonance imaging: Diagnostic accuracy of late gadolinium enhancement. American Heart Journal, 151, 101-108. doi:10.1016/j.ahj.2005.03.068

[16]   Ibrahim, T., Bulow, H.P., Hackl, T., et al. (2006) Diagnostic value of contrast-enhanced magnetic resonance imaging and single-photon emission computed tomogramphy for detection of myocardial necrosis early after acute myocardial infarction. Journal of the American College of Cardiology, 49, 208-216.

[17]   Kaandorp, T.A., Lamb, H.J., Viergever, E.P., et al. (2007) Scar tissue on contrast-enhanced MRI predicts left ventricular remodelling after acute infarction. Heart, 93, 375-376. doi:10.1136/hrt.2006.097675

[18]   Goerning, M., Liehr, M., Tute, C., Schlosser, M., Haueisen, J., Figulla, H. and Leder, U. (2009) Magnetocardiography based spatiotemporal correlation analysis is superior to conventional ECG analysis for identifying myocardial injury. Annals of Biomedical Engineering, 37, 107-111. doi:10.1007/s10439-008-9598-5

[19]   Sosnitskiy, V.N., Stadnyuk, L.A. and Sosnitskaya, T.V. (2004) Magnetocardiography: New insights onto old ideas. Heart and Vessels, 4, 73-78.

[20]   Ikefuji, H., Nomura, M., Nakaya, Y. et al. (2007) Visualization of cardiac dipole using a current density map: Detection of cardiac current undetectable by electrocardiography using magnetocardiography. Journal of Investigative Medicine, 54, 116-123. doi:10.2152/jmi.54.116

[21]   Jarusevicius, G., Navickas, R., Vainoras, A. et al.( 2004) JT interval changes in acute myocardial infarction following coronary angioplasty, Medicina (Kaunas), 40, 90-93.

[22]   Hondeghem, L.M., Carlsson, L., Duker, G. (2001) Insta-bility and triangulation of the action potential predict se-rious proarrhythmia, but action potential duration prolongation is antiarrhythmic. Circulation, 103, 2004-2013. doi:10.1161/01.CIR.103.15.2004

[23]   Antzelevitch, С. (2005) Modulation of transmural repolarization. Annals of the New York Academy of Sciences, 1047, 314-323

[24]   Emori, T. and Antzelevitch, C. (2001) Cellular basis for complex T wave and arrhythmic activity following combined I (kr) and I (ks) block. Journal of Cardiovascular Electrophysiology, 12, 1369-1378. doi:10.1046/j.1540-8167.2001.01369.x

[25]   Lu, H.R., Vlaminckx, E., Van Ammel, K., De Clerck, F. (2002) Drug—induced long QT in isolated rabbit Purkinje fibers: Importance of action potential duration, triangulation and early after depolarization. European Journal of Pharmacology, 452, 183-152. doi:10.1016/S0014-2999(02)02246-X

[26]   Milberg, P., Hilker, E., Ramtin, S., et al. (2007) Proarrhythmia as a class effect of quinolones: Increased dispersion of repolarization and triangulation of action potential predict torsades de points. Journal of Cardiovascular Electrophysiology, 18, 647-654. doi:10.1111/j.1540-8167.2007.00793.x

[27]   Kuzmin, V.S. and Rozenshtraukh, L.V. (2010) Ionic mechanisms as action of the III class antiarrhythmic drugs. Cardiology, 7, 49-61.

[28]   Sosnytskyy, V.M., Stadnyuk, L.A. and Sosnytska, T.V. (2010) Detection of the Ca2+ overload in patients presenting with delayed aftedepolarization using cardiac magnetic field mapping at rest. European Heart Journal, 31(Abstract Supplement), 264.