P. A. Greenberg, G. N. Hortobagyi, T. L. Smith, et al., “Long-Term Follow-Up of Patients with Complete Remission Following Combination Chemotherapy for Metastatic Breast Cancer,” Journal of Clinical Oncology, Vol. 14, 1996, pp. 2197-205.
 S. Dawood, K. Broglio, A. M. Gonzalez-Angulo, et al., “Trends in Survival over the Past Two Decades among White and Black Patients with Newly Diagnosed Stage IV Breast Cancer,” Journal of Clinical Oncology, Vol. 26, No. 23, 2008, pp. 4891-4898. doi:10.1200/JCO.2007.14.1168
 S. K. Chia, C. H. Speers, Y. D’Yachkova, et al., “The Impact of New Chemotherapeutic and Hormone Agents on Survival in a Population-Based Cohort of Women with Metastatic Breast Cancer,” Cancer, Vol. 110, No. 5, 2007, pp. 973-979. doi:10.1002/cncr.22867
 S. Germano and L. O’Driscoll, “Breast Cancer: Understanding Sensitivity and Resistance to Chemotherapy and Targeted Therapies to Aid in Personalised Medicine,” Current Cancer Drug Targets, Vol. 9, No. 3, 2009, pp. 398-418. doi:10.2174/156800909788166529
 M. C. De Martino, P. M. van Koetsveld, R. Pivonello, et al., “Role of the mTOR Pathway in Normal and Tumoral Adrenal Cells,” Neuroendocrinology, Vol. 92, Suppl 1, 2010, pp. 28-34. doi:10. 1159/000314280
 N. Margariti, S. B. Fox, A. Bottini, et al., “Overcoming Breast Cancer Drug Resistance with mTOR Inhibitors, Could It Be a Myth or a Real Possibility in the ShortTerm Future?” Breast Cancer Research and Treatment, Vol. 128, No. 3, 2011, pp. 599-606. doi:10.1007/s10549-010-0986-9
 G. Perez-Tenorio, L. Alkhori, B. Olsson, et al., “PIK3CA Mutations and PTEN Loss Correlate with Similar Prognostic Factors and Are Not Mutually Exclusive in Breast Cancer,” Clinical Cancer Research, Vol. 13, 2007, pp. 3577-3584. doi:10.1158/1078-0432.CCR-06-1609
 N. Shoman, S. Klassen, A. McFadden, et al., “Reduced PTEN Expression Predicts Relapse in Patients with Breast Carcinoma Treated by Tamoxifen,” Modern Pathology, Vol. 18, 2005, pp. 250-259. doi:10.1038/modpathol.3800296
 L. A. deGraffenried, W. E. Friedrichs, D. H. Russell, et al., “Inhibition of mTOR Activity Restores TamoxifenResponse in Breast Cancer Cells with Aberrant Akt Activity,” Clinical Cancer Research, Vol. 10, 2004, pp. 8059-8067. doi:10.1158/1078-0432.CCR-04-0035
 P. Chollet, C. Abrial, O. Tacca, et al., “Mammalian Target of Rapamycin Inhibitors in Combination with Letrozole in Breast Cancer,” Clinical Breast Cancer, Vol. 7, No. 4, 2006, pp. 336-338. doi:10.3816/CBC.2006.n.047
 K. Berns, H. M. Horlings, B. T. Hennessy, et al., “A Functional Genetic Approach Identifies the PI3K Pathway as a Major Determinant of Trastuzumab Resistance in Breast Cancer,” Cancer Cell, Vol. 12, 2007, pp. 395402. doi:10.1016/j.ccr.2007.08.030
 J. Tabernero, F. Rojo, E. Calvo, et al., “Doseand Schedule-Dependent Inhibition of the Mammalian Target of Rapamycin Pathway with Everolimus: A Phase I Tumor Pharmacodynamic Study in Patients with Advanced solid Tumors,” Journal of Clinical Oncology, Vol. 26, 2008, pp. 1603-1610. doi:10.1200/JCO.2007.14.5482
 A. O’Donnell, S. Faivre, H. A. Burris 3rd, et al., “Phase I Pharmacokinetic and Pharmacodynamic Study of the Oral Mammalian Target of Rapamycin Inhibitor Everolimus in Patients with Advanced Solid Tumors,” Journal of Clinical Oncology, Vol. 26, 2008, pp. 1588-1595. doi:10.1200/JCO.2007.14.0988
 L. W. C. Chow, J. Jassem, et al., “Phase 3 Study of Temsirolimus with Letrozole or Letrozole Alone in Postmenopausal Women with Locally Advanced or Metastatic Breast Cancer,” Presented at the 29th Annual San Antonio Breast Cancer Symposium, San Antonio, 14-17 December 2006.
 T. Bachelot, C. Bourgier, C. Cropet, et al., “Randomized Phase II Trial of Everolimus in Combination with Tamoxifen in Patients with Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Metastatic Breast Cancer with Prior Exposure to Aromatase Inhibitors: A GINECO Study,” Journal of Clinical Oncology, Vol. 30, 2012, pp. 2718-2724. doi:10. 1200/JCO. 2011.39.0708
 A. Awada, F. Cardoso, C. Fontaine, et al., “The Oral mTOR Inhibitor RAD001 (Everolimus) in Combination with Letrozole in Patients with Advanced Breast Cancer: Results of a Phase I Study with Pharmacokinetics,” European Journal of Cancer, Vol. 44, No. 1, 2008, pp. 84-91. doi:10.1016/j.ejca.2007.10.003
 J. Baselga, V. Semiglazov, P. van Dam, et al., “Phase II Randomized Study of Neoadjuvant Everolimus Plus Letrozole Compared with Placebo Plus Letrozole in Patients with Estrogen Receptor-Positive Breast Cancer,” Journal of Clinical Oncology, Vol. 27, 2009, pp. 2630-2637. doi:10.1200/JCO. 2008.18.8391
 F. Badin, M. Chambers, et al., “A Phase II Trial of Fulvestrant and RAD001 (Everolimus) in Patients with Metastatic Estrogen Receptor Positive Breast Cancer after Aromatase Inhibitor Failure: A Study in Progress,” Presented at the 33rd Annual San Antonio Breast Cancer Symposium, San Antonio, 8-12 December 2010.
 J. Baselga, M. Campone, M. Piccart, et al., “Everolimus in Postmenopausal Hormone-Receptor-Positive Advanced Breast Cancer,” New England Journal of Medicine, Vol. 366, No. 6, 2012, pp. 520-529. doi:10.1056/NEJMoa1109653
 J. S. Ross, E. A. Slodkowska, W. F. Symmans, et al., “The HER-2 Receptor and Breast Cancer: Ten Years of Targeted Anti-HER-2 Therapy and Personalized Medicine,” Oncologist, Vol. 14, No. 4, 2009, pp. 320-368. doi:10.1634/theoncologist.2008-0230
 J. Baselga, J. Cortes, S. B. Kim, et al., “Pertuzumab Plus Trastuzumab Plus Docetaxel for Metastatic Breast Cancer,” New England Journal of Medicine, Vol. 366, No. 2, 2012, pp. 109-119. doi:10.1056/NEJMoa1113216
 F. Andre, M. Campone, R. O’Regan, et al., “Phase I Study of Everolimus Plus Weekly Paclitaxel and Trastuzumab in Patients with Metastatic Breast Cancer Pretreated with Trastuzumab,” Journal of Clinical Oncology, Vol. 28, No. 34, 2010, pp. 5110-5115. doi:10.1200/JCO.2009.27.8549
 F. C. M. Dalenc, P. Hupperets, et al., “Everolimus in Combination with Weekly Paclitaxel and Trastuzumab in Patients (pts) with HER-2-Overexpressing Metastatic Breast Cancer (MBC) with Prior Resistance to Trastuzumab and Taxanes: A Multicenter Phase II Clinical Trial,” American Society of Clinical Oncology Annual Meeting, Chicago, 4-8 June 2010.
 G. Jerusalem, A. Fasolo, V. Dieras, et al., “Phase I Trial of Oral mTOR Inhibitor Everolimus in Combination with Trastuzumab and Vinorelbine in Pre-Treated Patients with HER2-Overexpressing Metastatic Breast Cancer,” Breast Cancer Research and Treatment, Vol. 125, No. 2, 2011, pp. 447-455. doi:10.1007/s10549-010-1260-x
 G. F. A. Jerusalem, C. Massacesi, et al., “Maintenance with Everolimus (RAD001) and Trastuzumab (T) after Discontinuation of Chemotherapy in Heavily Pre-Treated HER-2 + Metastatic Breast Cancer (MBC) Patients (pts): Pooled Data of Extension Cohorts of Phase Ib/II Studies,” American Society of Clinical Oncology Annual Meeting, Chicago, 4-8 June 2010.
 M. G. L. Campone, C. Massacesi, et al., “Trastuzumab (H) and Everolimus (RAD001) Containing Regimens Are Safe and Active When Reintroduced in Patients (pts) with HER2-Overexpressing Metastatic Breast Cancer (MBC) Pre-Treated with Lapatinib [Abstract],” European Journal of Cancer Supplements, Vol. 8, 2010, p. 186. doi:10.1016/S1359-6349(10)70458-4
 P. K. Morrow, G. M. Wulf, J. Ensor, et al., “Phase I/II Study of Trastuzumab in Combination with Everolimus (RAD001) in Patients with HER2-Overexpressing Metastatic Breast Cancer Who Progressed on TrastuzumabBased Therapy,” Journal of Clinical Oncology, Vol. 29, No. 23, 2011, pp. 3126-3132. doi:10.1200/JCO.2010.32.2321
 I. A. B. H. Mayer, J. Bendel, et al., “A Phase Ib Trial of RAD001, an mTOR Inhibitor, with Weekly Cisplatin and Paclitaxel in Patients with HER2-Negative Metastatic Breast Cancer,” 32nd Annual San Antonio Breast Cancer Symposium, San Antonio, 9-13 December 2009.
 A. M. G. M. Gonzalez-Angulo, J. L. Murray, et al., “Open Label Randomized Clinical Trial of Standard Neoadjuvant Chemotherapy with Paclitaxel Followed by FEC (TFEC) vs the Combination of Paclitaxel and RAD001 Followed by FEC (TR-FEC) in Women with Triple Receptor-Negative Breast Cancer (TNBC),” American Society of Clinical Oncology Annual Meeting, Chicago, 3-7 June 2011.