Necrotizing scleritis is the most
severe form of scleritis with a significant threat to vision and globe
integrity. It can be infectious, surgically induced necrotizing scleritis
(SINS) or systemic autoimmune associated. We report a case of necrotizing
scleritis associated with 5-fluorouracil (5-FU) at the site of sub tenon’s
block in a patient with previous trabeculectomy. To our knowledge, this is the first reported case of
necrotizing scleritis associated with 5-FU. This may implicate alternative
approaches to local anaesthetic techniques when using adjunctive 5-FU.
Cite this paper
T. Tran, J. O’Connor, X. Fagan, T. Tran and D. Nguyen, "Necrotizing Scleritis Associated with 5-Fluorouracil and Sub-Tenon’s Block in Patient with Previous Trabeculectomy: A Case Report," Open Journal of Ophthalmology, Vol. 3 No. 3, 2013, pp. 73-75. doi: 10.4236/ojoph.2013.33018.
 D. Wakefield, N. Di Girolamo, S. Thurau, G. Wildner and P. McCluskey, “Scleritis: Immunopathogenesis and Molecular Basis for Therapy,” Progress in Retinal and Eye Research, Vol. 35, 2013, pp. 44-62.
 M. Sainz de la Maza, N. Molina, L. A. Gonzalez-Gonzalez, P. P. Doctor, J. Tauber and C. S. Foster, “Clinical Characteristics of a Large Cohort of Patients with Scleritis and Episcleritis,” Ophthalmology, Vol. 119, No. 1. 2012, pp. 43-50. doi:10.1016/j.ophtha.2011.07.013
 E. K. Akpek, J. E. Thorne, F. A. Qazi, D. V. Do and D. A. Jabs, “Evaluation of Patients with Scleritis for Systemic Disease,” Ophthalmology, Vol. 111, No. 3, 2004, pp. 501-506. doi:10.1016/j.ophtha.2003.06.006
 L. M. Abraham, D. Selva, R. Casson and I. Leibovitch, “The Clinical Applications of Fluorouracil in Ophthalmic Practice,” Drugs, Vol. 67, No. 2, 2007, pp. 237-255.
 R. R. Doshi, G. J. Harocopos, I. R. Schwab and E. T. Cunningham Jr., “The Spectrum of Postoperative Scleral Necrosis,” Survey of Ophthalmology, 2013. (in Press)