WJNS  Vol.3 No.3 , August 2013
Description of interhemispheric disconnection syndrome in a patient with Marchiafava-Bignami disease
ABSTRACT

Interhemispheric disconnection syndrome (IDS), described by Sperry, Gazzaniga and Bogen, is characterized by the presence of visual and tactile anomia, absence of interhemispheric transference of unilateral somatosensory stimulation of both hands, hemialexia and unilateral left-side apraxia. Subsequently, changes were also observed in the sensory interhemispheric transfer and in tests of crossed motor control. In Marchiafava-Bignami disease (MBD) there have been descriptions of partial IDS. The aim is to describe the dissociations in IDS that are presented in a patient with MBD, using a specialized assessment methodology. Patient and Method: A 54-year-old patient, righthanded, with 11 years of schooling, presented with antecedent chronic alcoholism. Neuropsychological tests were administered for general assessment along with specific tests of interhemispheric transference. Results: Borderline changes were found in visual memory, visual-constructive abilities and attention and executive functioning. In tasks of interhemispheric transference the patient showed changes in: the imitation of hand poses; inter-manual pressure point localization (tactile stimulation); reading aloud of words by visual hemifield; and movement control. Conclusion: Our patient showed a wide lesion of the Corpus Callosum (CC) with relative preservation of the splenium, accompanied by partial disconnection syndrome in the context of a global cognitive deterioration from his chronic alcoholism.


Cite this paper
Politis, D. , Tirigay, R. , Gómez, P. and Tabernero, M. (2013) Description of interhemispheric disconnection syndrome in a patient with Marchiafava-Bignami disease. World Journal of Neuroscience, 3, 190-197. doi: 10.4236/wjns.2013.33024.
References
[1]   Sperry, R., Gazzaniga, M. and Bogen, J. (1987) Interhemisferic relatonships: The neocortical commissures, syndromes of hemisphere disconnection. In: Vinken, P., Bruyn, G. and Klawans, H., Eds., Handbook of Clinical Neurology, Elsevier, Amsterdam, 273-290.

[2]   Lausberg, H. and Cruz, R. (2004) Hemispheric specialisation for imitation of hand-head positions and finger configurations: A controlled study in patients with complete callosotomy. Neuropsychologia, 42, 320-334. doi:10.1016/j.neuropsychologia.2003.08.003

[3]   Navarro, J.F. and Noriega, S. (1999) Enfermedad de Marchiafava-Bignami. Revista de Neurología, 28, 519-523.

[4]   Castaigne, P., Buge, A., Cambier, J., Escourolle, R. and Rancurel, G. (1971) La maladie de Marchiafava-Bignami. Etude anatomo-clinique de 10 observations. Revue Neurologique (Paris), 125, 179-186.

[5]   Vázquez, C., Salamano, R., Legnani, C. and Cardinal, P. (2008) Enfermedad de Marchiafava-Bignami en uruguay. Neurología, 23, 322-328.

[6]   Gambini, A., Falini, A., Moiola, L., Comi, G. and Scotti, G. (2003) Marchiafava-Bignami disease: Longitudinal MR imaging and MR spectroscopy study. American Journal of Neuroradiology, 24, 249-253.

[7]   Arbelaez, A.P. and Castillo, M. (2003) Acute Marchiafava-Bignami disease: MR findings in two patients andres. American Journal of Neuroradiology, 24, 1955-1957.

[8]   Chang, K.H., Cha, S.H., Han, M.H., Park, S.H., Nah, D.L. and Hong, J.H. (1992) Marchiafava-Bignami disease: Serial changes in corpus callosum on MRI. Neuroradiology, 34, 480-482. doi:10.1007/BF00598954

[9]   Lhermitte, F., Marteau, R., Serdaru, M. and Chedru, F. (1977) Signs of interhemispheric disconnection in marchiafava-bignami disease. Archives of Neurology, 34, 254. doi:10.1001/archneur.1977.00500160068015

[10]   Lechevalier, B., Andersson, J.C. and Morin, P. (1977) Hemispheric disconnection syndrome with a “crossed avoiding” reaction in a case of Marchiafava-Bignami disease. Journal of Neurology, Neurosurgery, and Psychiatry, 40, 483-497. doi:10.1136/jnnp.40.5.483

[11]   Kamaki, M., Kawamura, M., Moriya, H. and Hirayama, K. (1993) “Crossed homonymous hemianopia” and “crossed left hemispatial neglect” in a case of MarchiafavaBignami disease. Journal of Neurology, Neurosurgery, and Psychiatry, 56, 1027-1032. doi:10.1136/jnnp.56.9.1027

[12]   Berek, K., Wagner, M., Chemelli, A.P., Aichner, F. and Benke, T. (1994) Hemispheric disconnection in Marchiafava-Bignami disease: Clinical, neuropsychological and MRI findings. Journal of the Neurological Sciences, 123, 2-5. doi:10.1016/0022-510X(94)90195-3

[13]   Kalckreuth, W., Zimmermann, P., Preilowski, B. and Wallesch, C.W. (1994) Incomplete split-brain syndrome in a patient with chronic Marchifava-Bignami disease. Behavioural Brain Research, 64, 219-228. doi:10.1016/0166-4328(94)90134-1

[14]   Hirayama, K., Tachibana, K., Abe, N., Manabe, H., Fuse, T. and Tsukamoto, T. (2008) Simultaneously cooperative, but serially antagonistic: A neuropsychological study of diagonistic dyspraxia in a case of Marchiafava-Bignami disease. Neuroscience and Behavioural Neuroscience, 19, 137-144.

[15]   Allegri, R.F., Ollari, J.A., Mangone, C.A., Arizaga, R.L., De Pascale, A., Pellegrini, M., et al. (1999) “Minimental State Examination” en la Argentina: Instrucciones para su administración. Neurológica Argentina, 24, 31-35.

[16]   Folstein, M.F., Folstein, S.E. and McHugh, P.R. (1975) “Mini-mental state” a practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12, 189-198. doi:10.1016/0022-3956(75)90026-6

[17]   Freedman, M., Learch, K., Kaplan, E., Winocur, G., Shulman, K.I. and Delis, D. (1994) Clock drawing: A neuropsychological analysis. Oxford University Press Inc., New York.

[18]   Artiola, L., Hermosillo Romo, D., Heaton, R.K. and Pardee, R.E. (1999) Batería neuropsicológica en espanol. Pardee III Press, Tucson.

[19]   Reitan, R. and Wolfson, D. (1985) The halstead-reitan neuropsychological test battery. Neuropsychology Press, Tucson.

[20]   Butman, J., Allegri, R.F., Harris, P. and Drake, M. (2000) Fluencia verbal en espanol. Datos normativos en argentina. Medicina, 60, 561-564.

[21]   Meyers, J.E. and Meyers, K.R. (1995) Rey complex figure test and recognition trial. Profesional manual. Psychological Assessment Resources, Odessa.

[22]   Goodglass, H. and Kaplan, E. (1996) Evaluación de la afasia y de trastornos relacionados. 2nd Edition, Panamericana, Madrid.

[23]   Wechsler, D. (2002) WAIS III: Test de inteligencia para adultos. Manual técnico. Buenos Aires, Paidós.

[24]   Shallice, T. (1982) Specific impairments of planning. Philosophical Transactions of the Royal Society of London B, 298, 199-209. doi:10.1098/rstb.1982.0082

[25]   Shallice, T. (1988) From neuropsychology to mental structure. Cambridge University Press, Cambridge. doi:10.1017/CBO9780511526817

[26]   Kongs, K.S., Thompson, L.L., Iverson, G.L. and Heaton, R.K. (2000) Wisconsin card sorting test-64 card version (WCST-64). Psychological Assessment Resources, Odessa.

[27]   Politis, D., Ferreres, A. and Bonafina, M. (1998) Neuropsychological rehabilitation in a case of asterognosia. VI Yearbook faculty research in psychology. Universidad de Buenos Aires, Ciudad de Buenos Aires, 372-383.

[28]   Politis, D. and Margulis, L. (1997) Evaluación de las praxias a partir de un modelo cognitivo. Neuropsychologia Latina, 3, 92.

[29]   Politis, D. (2003) Nuevas perspectivas en la evaluación de las apraxias. Universidad de Buenos Aires, Buenos Aires.

[30]   Abboud, H. and Sugar, D. (1997) Superlab pro, version 1.04. Cedrus Corporation, Phoenix.

[31]   Ferreres, A., Grus, J., Jacubovich, S., Jaichenco, V., Kevorkian, A., Piaggio, V., et al. (1999) Batería para el análisis de los déficits afásicos. JVE Ediciones, Buenos Aires.

[32]   Miceli, G., Laudanna, A., Burani, C. and Capasso, C. (1991) Battería per l’analisi dei defcit afasici. Berdata, Milán.

[33]   Levine, S.C. and Banich, T. (1982) Lateral asymetries in the naming of words and corresponding line drawings. Brain and Language, 17, 34-45. doi:10.1016/0093-934X(82)90003-7

[34]   Namba, Y., Bando, M., Takeda, K., Iwata, M. and Mannen, T. (1991) Marchiafava-Bignami disease with symptoms of the motor impersistence and unilateral hemispatial neglect. Rinsho Shinkeigaku, 31, 632-635.

[35]   Heinrich, A., Runge, U. and Khaw, A. (2004) Clinicoradiologic subtypes of Marchiafava-Bignami disease. Journal of the Neurological Sciences, 251, 1050-1059.

[36]   Liepmann, H. and Mass, O. (1908) Fall von linksseitiger agraphie und apraxie bei rechtsseitiger Ilihmung. Journal für Psychologie und Neurologie, 1, 214-227.

[37]   Bogen, J.E. (1987) Physiological consequences of complete or partial commissural section. In: Apuzzo, M.L.J., Ed., Surgery of the Third Ventricle, Williams & Wilkins, Baltimore, 175-194.

[38]   Zaidel, D. and Sperry, R.W. (1977) Some long-term motor effects of cerebral commissurotomy in man. Neuropsychologia, 15, 193-204. doi:10.1016/0028-3932(77)90028-8

[39]   Barbizet, J., Degos, J.D., Lejeune, A. and Leroy, A. (1978) Interhemispheric disconnection syndrome with diagnostic dyspraxia in the course of Marchiafava-Bignami disease. Revue Neurologique, 134, 781-789.

[40]   Apuzzo, M.L., Chikovani, O.K., Gott, P.S., Teng, E.L., Zee, C.S., Giannotta, S.L. and Weiss, M.H. (1982) Transcallosal, interfornicial approaches for lesions affecting the third ventricle: Surgical considerations and consequences. Neurosurgery, 10, 547-554. doi:10.1227/00006123-198205000-00001

[41]   Purves, S.J., Wada, J.A., Woodhurst, W.B., Moyes, P.D., Strauss, E., Kosaka, B. and Li, D. (1988) Results of anterior corpus callosum section in 24 patients with medically intractable seizures. Neurology, 38, 1194-1201. doi:10.1212/WNL.38.8.1194

[42]   Gordon, H.W. (1990) Neuropsychological sequelae of partial commissurotomy. In: Boiler, F. and Grafman, J., Eds., Handbook of Neuropsychology, Amsterdam, Elsevier.

[43]   Levin, H.S., Mattson, A.J., Levander, M., Lindquist, C.E., Simard, J.M., Guinto, F.C., Lilly, M.A. and Eisenberg, H.M. (1993) Effects of transcallosal surgery on interhemispheric transfer of information. Surgical Neurology, 40, 65-74. doi:10.1016/0090-3019(93)90174-Y

[44]   Kuypers, H. (1981) Anatomy of the descending pathways. In: Brooks, V., Ed., The Nervous System, Handbook of Physiology, Vol. 2, Williams and Wilkins, Baltimore, 597-666.

[45]   Bentin, S., Sahar, A. and Moscovitch, M. (1984) Intermanual information transfer in patients with lesions in the trunk of the corpus callosum. Neuropsychology, 22, 601-611. doi:10.1016/0028-3932(84)90024-1

[46]   Jeeves, M.A. (1979) Some limits to interhemispheric integration in cases of callosal agenesis and partial commissurotomy. In: Russell, I.S., von Hof, M.W. and Berlucchi, G., Eds., Structure and Function of Cerebral Commissures, University Park Press, Baltimore.

[47]   Sugishita, M., Shinohara, A., Shimoji, T. and Ogawa, T. (1985) A remaining problem in hemialexia: Tachistoscopis hemineglect and hemialexia. In: Reeves, A.G., Ed., Epilepsy and the Corpus Callosum, Plenum Press, New York, 417-434.

[48]   Sugishita, M. and Yoshioka, M. (1987) Visual processes in a hemialexic patient with posterior callosal section. Neuropsychologia, 25, 329-339. doi:10.1016/0028-3932(87)90022-4

[49]   Gazzaniga, M.S. (2000) Cerebral specialization and interhemispheric communication. Does the corpus callosum enable the human condition? Brain, 123, 1293-1326. doi:10.1093/brain/123.7.1293

[50]   Suzuki, K., Yamadori, A., Endo, K., Fujii, T., Ezura, M. and Takahashi, A. (1998) Dissociation of letter and picture naming resulting from callosal disconnection. Neurology, 51, 1390-1394. doi:10.1212/WNL.51.5.1390

[51]   Funnell, M.G., Corballis, P.M. and Gazzaniga, M.S. (2000) Insights into the functional specificity of the human corpus callosum. Brain, 123, 920-926. doi:10.1093/brain/123.5.920

 
 
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