In the present study, we developed silicosis of
rat model by bronchial perfusion SiO2 dust, and intervenes with
AcSDKP, immunohisto chemistry was used to detect NF-κb and MCP-1 expression in lung
tissue, and positive cells were counted. We found that compared with silicotic
model group, the positive cells of NF-κb and MCP-1 were decreased significantly
in anti-fibrosis treatment of AcSDKP group. The findings suggest that AcSDKP could inhibit the expression of NF-κb
and MCP-1 in lung tissue of silicosos, this may be related to AcSDKP inhibit of
macrophage infiltration in lung tissue and reduced the degree of dust
Cite this paper
Q. Li, F. Yang, L. J. Zhang, H. Xu and W. L. Zhang, "The Effects of N-acetyl-seryl-aspartyl-lysyl-proline on Expression of NF-κb and MCP-1 in Rats with Silicosis," International Journal of Clean Coal and Energy, Vol. 2 No. 2B, 2013, pp. 24-26. doi: 10.4236/ijcce.2013.22B006.
 G. Semenzalo, F. Adami, N. Maschio, et al., “Immune Mechanisms in Interstitial Lung Disease,” Allergy, Vol. 55, 2000, pp. 1103-1120.
 S. Ying, Y. Fang, Y. Jingbo, et al., ”New Anti-fibrotic Mechanisms of N-acetyl-seryl-aspartyl-lysyl-proline in Silicon Dioxide-induced Silicosis,” Life Sciences, Vol. 87, No. 3, 2010, pp. 232-239.
 M. D. Gunn, N. A. Nelken, X. Liao, et al., “Monocyte Chemo Attractant Protein-1 Is Sufficient for the Chemotaxis of Monocyte and Lymphocytes in Transgenic Mice but Requires an Additional Stimulus for Inflammatory Activation, Journal of Immunol, Vol. 158, No. 1, 1997, pp. 376-383.
 I. Inoshima, Kuwano K, Hamada N, et al., “Anti-monocyte Chemo Attractant Protein-1 Gene Therapy Attenuates Pulmonary Fibrosis in Mice Am,” Journal of Physiol Lung Cell Mol Physiol, Vol. 286, No. 5, 2004, pp. L1038 - L1044.
 P. A. Henriksen, M. Hitt, Z. Xing, et al., “Adenoviral Gene Delivery of Elafin and Secretory Leukocyte Protease Inhibitor Attenuates NF-kappa B-dependent Inflammatory Responses of Human Endothelial Cells and Macrophages to Atherogenic Stimuli,” Journal of Immunol, Vol. 172, No. 7, 2004, pp. 4535-4544.
 Z. Y. Tao, A. Maria Cavasin, F. Yang, Y. H. Liu and X. P. Yang, “Temporal Changes in Matrix Metalloproteinase Expression and Inflammatory Response Associated with Cardiac Rupture after Myocardial Infarction in Mice,” Life Science, Vol. 74, No. 12, 2004, pp. 1561-1572.