APD  Vol.2 No.3 , August 2013
Factors affecting early decline of executive function after subthalamic nucleus stimulation in Parkinson’s disease
ABSTRACT
Subthalamic nucleus deep brain stimulation (STN DBS) is an effective treatment for medically refractory Parkinson’s disease (PD). However, a minority of patients develop cognitive problems, particularly a decline of executive function in the early period after STN DBS. Although this problem is usually transient, it may cause social maladjustment. We investigated factors affecting early decline of executive function after STN-DBS. Fifty-seven patients whose preoperative global cognitive screening was normal (MMSE score; 28 or more) were enrolled in this study. Executive function was evaluated with the Trail-Making Test (TMT) preoperatively and 1-month after surgery. We considered a patient to have decline in executive function if the TMT (B-A) was prolonged more than 30 seconds after STN DBS. Among 57 patients, 25 patients were categorized as having decline of executive function. Univariate analysis revealed that high preoperative UPDRS III motor score in the medication-off period and a depressive state evaluated with BDI-II correlated significantly with decline in executive function. Multiple logistic regression analysis revealed that the only significant independent variable related to early decline of executive function was the preoperative BDI-II score. Postoperative factors such as active contact location or dopaminergic medication reduction had no relation with the decline of executive function. Even in cognitively well-selected patients, STN DBS causes early decline in executive function in a significant number of patients. Preoperative simple cognitive screening alone could not predict early decline in executive function. More detailed neuropsychological evaluation, including mood status, should be undertaken before surgery.

Cite this paper
Umemura, A. , Oka, Y. , Tsuboi, R. , Fujii, S. , Shimizu, Y. , Okita, K. , Matsukawa, N. and Yamada, K. (2013) Factors affecting early decline of executive function after subthalamic nucleus stimulation in Parkinson’s disease. Advances in Parkinson's Disease, 2, 75-80. doi: 10.4236/apd.2013.23015.
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