ABSTRACT Mineral trioxide aggregate (MTA) has been found to be very biocompatible in a large number of studies. However, the handling properties can be challenging and research on modified materials to enhance placement are few. The purpose of this study is to compare a new faster setting, and more easily placed preparation with classic MTA in an animal model. Canine premolar teeth from two dogs were randomized and received quadrant surgery timed to allow 50 day and 98 day comparisons. Histologic and radiographic comparisons were made. Results were essentially equal in healing, even close to the materials.
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Eleazer, P. , Rhodes, S. , Horn, D. , DeVilliers, P. , Wei, S. , Novak, L. , Dohm, E. , Weems, R. and Litaker, M. (2013) In vivo evaluation of an experimental root-end filling material versus MTA. Open Journal of Animal Sciences, 3, 19-23. doi: 10.4236/ojas.2013.33A003.
 Torabinejad, M., Watson, T.F. and Pitt-Ford, T.R. (1993) Sealing ability of a mineral trioxide aggregate used as a root end filling material. Journal of Endodontics, 19, 591-595. doi:10.1016/S0099-2399(06)80271-2
 Parirokh, M. and Torabinejad, M. (2010) Mineral trioxide aggregate: A comprehensive literature review—Part I: Chemical, physical, and antibacterial properties. Journal of Endodontics, 36, 16-27.
 Torabinejad, M. and Parirokh, M. (2010) Mineral trioxide aggregate: A comprehensive literature review—Part II: Leakage and biocompatibility investigations. Journal of Endodontics, 36, 190-202.
 Parirokh, M. and Torabinejad, M. (2010) Mineral trioxide aggregate: A comprehensive literature review—Part III: Clinical applications, drawbacks and mechanism of action. Journal of Endodontics, 36, 400-413.
 von Arx, T., Hanni, S. and Jensen, S.S. (2010) Clinical results with two different methods of root-end preparation and filling in apical surgery: Mineral trioxide aggregate and adhesive resin composite. Journal of Endodontics, 36, 1122-1129. doi:10.1016/j.joen.2010.03.040
 Wang, Y., Cheung, G.S., Xu, X., Zhao, S. and Zhang, C. (2010) The effect of cultured autologous periodontal ligament cells on the healing of delayed autotransplanted dog’s teeth. Journal of Endodontics, 36, 264-267.
 Brasil, D.S., Soares, J.A., Horta, M.C.R., Ferreira, C.L., Nunes, E., Chaves, G.G. and Silvera, F.F. (2010) Periapical repair in dog teeth: Root canal adhesive filling by using the Resilon system. Journal of Endodontics, 36, 482488. doi:10.1016/j.joen.2009.11.020
 Yasuda, F., Ogawa, M., Arakawa, T., Kadowaki, T. and Saito, T. (2008) The effect of mineral trioxide aggregate on the mineralization ability of rat dental pulp cells: An in vitro study. Journal of Endodontics, 34, 1057-1060.
 Meade, H., Nakano, T., Tomokiyo, A., Fujii, S., Wada, N., Monnouchi, S., Hori, K. and Akamine, A. (2010) Mineral trioxide aggregate induces bone morphogenetic protein-2 expression and calcification in human periodontal ligament cells. Journal of Endodontics, 36, 647-652.
 Asgary, S., Eghbal, M.J. and Ehsani, S. (2010) Periradicular regeneration after endodontic surgery with calciumenriched mixture cement in dogs. Journal of Endodontics, 36, 837-841. doi:10.1016/j.joen.2010.03.005
 Hakki, S.S., Bozkurt, S.B., Hakki, E.E. and Belli, S. (2009) Effects of mineral trioxide aggregate on cell survival, gene expression associated with mineralized tissues, and biomineralization of cementoblasts. Journal of Endodontics, 35, 513-519. doi:10.1016/j.joen.2008.12.016