Primary non-Hodgkin’s lymphomas is an uncommon disease representing approximately 0.13% of all reported malignant mammary neoplasms. Clinically they are mainly observed as solitary lesions, but may also be seen as multiple foci. Herein, we present a very rare case with the diagnosis of multifocal malignant lymphoma of the breast. Case: A 56-year-old-female patient with a right palpable breast mass admitted to the hospital. Mammography and ultrasonography findings showed two different foci of hypoechoic solid mass forming lesion in the right breast. Excisional biopsy has been performed. In the histopathological evaluation, both lesions demonstrated foci of necrosis; mitotically active tumor cells with large nucleus and prominent nucleoli. The immunohistochemical analysis revealed diffuse LCA, CD20, CD43, focal CD68 positivity while pancytokeratin, EMA, CD34, SMA were negative. The case was diagnosed as Diffuse Large B-cell Lymphoma. We report a very rare case with a diagnosis of multifocal primary non-Hodgkin’s lymphoma of the breast.
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