influences the function of skeletal muscle, modifying fibre structure, metabolism
and promoting the release of growth factors and other signalling molecules. The number of satellite cells under
the basal lamina of type I and type IIA muscle fibres increases during endurance
training and under the basal lamina of both type II fibres during resistance training. An increase in satellite
cells is related to several factors
expressing different genes and type II muscle fibre hypertrophy. Insulin-like
growth factor-I has a role in the hypertrophy of muscle fibres through the
stimulation of the differentiation of satellite cells. The increased mitochondrial biogenesis via adenosine myophosphate-activated protein kinase is
accompanied by the suppression of myofibrillar protein synthesis through
pathways mediated by mitogen-activated protein kinases and the nuclear factor
kappa B. Insulin-like growth factor-I expression
is higher in type I fibres. Myostatin, the expression inhibitor of
muscle hypertrophy, is higher in type II fibres.
The proteasome-, lysosome- and Ca2+-mediated protein
degradation is more intensive in fibres with higher oxidative capacity. Both,
oxidative capacity and satellite cells number in muscle fibres play
important roles in skeletal muscle regeneration. In this review, we explore
the regeneration capacity changes in different types of skeletal muscle fibres
in response to resistance, endurance and overtraining.
Cite this paper
Seene, T. and Kaasik, P. (2013) Muscle damage and regeneration: Response to exercise training. Health, 5, 136-145. doi: 10.4236/health.2013.56A2020.
 Kendall, B. and Eston, R. (2002) Exercise-induced muscle damage and the potential protective role of estrogen. Sports Medicine, 32, 103-123.
 Kibler, W.B. and Chandler, T.J. (1998) Musculoskeletal and orthopedic considerations. In: Kreider, R.B., Fry, A.C. and O’Toole, M.L., Eds., Overtraining in Sport, Human Kinetics, Champaign, 169-190.
 Fridén, J., Leiber, R.L. and Thornell, L.E. (1991) Subtle indications of muscle damage following eccentric contractions. Acta Physiologica Scandinavica, 142, 523-524.
 Perrey, S. and Rupp, T. (2009) Altitude-induced changes in muscle contractile properies. High Altitude Medicine & Biology, 10, 175-182. doi:10.1089/ham.2008.1093
 Gibala, M. (2009) Molecular responses to high-intensity interval exercise. Applied Physiology, Nutrition, and Metabolism, 34, 428-432. doi:10.1139/H09-046
 Seene, T., Umnova, M., Kaasik, P., Alev, K. and Pehme, A. (2008) Overtraining injuries in athletic population. In: Tiidus, P.M. Ed., Skeletal Muscle Damage and Repair, Human Kinetics, Champaign, 305-307.
 Wijnberg, I.D., van Dam, K.G., Graaf-Roelfsema, E., Keizer, H.A., van Ginneken, M.M., Barneveld, A., Breda, E. and van der Kolk, J.H. (2008) (Over)training effects on quantitative electromyography and muscle enzyme activities in standardbred horses. Journal of Applied Physiology, 105, 1746-1753.
 Duguez, S., Féasson, L., Denis, C. and Freyssenet, D. (2002) Mitochondrial biogenesis during skeletal muscle regeneration. American Journal of Physiology. Endocrinology and Metabolism, 282, E802-E809.
 Wagers, A.J. and Conboy, I.M. (2005) Cellular and molecular signatures of muscle regeneration: Current concepts and controversies in adult myogenesis. Cell, 122, 659-667.
 Conboy, I.M. and Rando, T.A. (2002) The regulation of Notch signaling controls satellite cell activation and cell fate determination in postnatal myogenesis. Developmental Cell, 3, 397-409.
 Charge, S.B. and Rudnicki, M. A. (2004) Cellular and molecular regulation of muscle regeneration. Physiological Reviews, 84, 209-238.
 Mauro, A. (1961) Satellite cell of skeletal muscle fibres. The Journal of Biophysical and Biochemical Cytology, 9, 493-495.
 Seene, T., Kaasik, P. and Umnova, M. (2009) Structural rearrangements in contractile apparatus and resulting skeletal muscle remodelling: Effect of exercise training. Journal of Sports Medicine and Physical Fitness, 49, 410-423.
 Umnova, M. and Seene, T. (1991) The effect of increased functional load on the activation of satellite cells in the skeletal muscle of adult rats. The International Journal of Sports Medicine, 12, 501-504.
 Grounds, M.D. (1999) Muscle regeneration: Molecular aspects and therapeutic implications. Current Opinion in Neurology, 12, 535-543.
 Broholm, C. and Pedersen, B.K. (2010) Leukaemia inhibitory factor—An exercise induced myokine. Exercise Immunology Review, 16, 77-85.
 Angione, A.R., Jiang, C., Pan, D., Wang, Y.-X. and Kuang, S. (2011) PPARδ regulates satellite cell proliferation and skeletal muscle regeneration. Skeletal Muscle, 1, 1-16.
 Zeng, L., Akasaki, Y., Sato, K., Ouchi, N., Izumiya, Y. and Walsh, K. (2010) Insulin-like 6 is induced by muscle injury and functions as a regenerative factor. The Journal of Biological Chemistry, 285, 36060-36069.
 Magaudda, L., Di Mauro, D., Trimarchi, F. and Anastasi, G. (2004) Effects of physical exercise on skeletal muscle fiber: ultrastructural and molecular aspects. Basic Applied Myology, 14, 17-21.
 Gibson, M.C. and Schultz, E. (1982) The distribution of satellite cells and their relationship to specific fiber types in soleus and extensor digitorum longus muscles. The Anatomical Record, 202, 329-337.
 Gibson, M.C. and Schultz, E. (1983) Age-related differrences in absolute numbers of skeletal muscle satellite cells. Muscle & Nerve, 6, 574-580.
 Putman, C.T., Düsterhöft, S. and Pette, D. (2000) Satellite cell proliferation in low frequency-stimulated fast muscle of hypothyroid rat. American Journal of Physiology. Cell Physiology, 279, C682-C690.
 Putman, C.T., Sultan, K.R., Wassmer, T., Bamford, J.A., Skorjanc, D. and Pette, D. (2001) Fiber-type transitions and satellite cell activation in low-frequency-stimulated muscles of young and aging rats. The Journal of Gerontology, Series A, Biological Sciences and Medical Sciences, 56, B510-B519. doi:10.1093/gerona/56.12.B510
 Apell, H.J., Forsberg, S. and Hollmann, W. (1988) Satellite cell activation in human skeletal muscle after training: Evidence for muscle fiber neoformation. The International Journal of Sports Medicine, 9, 297-299.
 Martins, K.J., Gordon, T., Pette, D., Dixon, W.T., Foxcroft, G.R., McLean, I.M. and Putman, C.T. (2006) Effect of satellite cell ablation on low-frequency-stimulated fast- to-slow fibre-type transitions in rat skeletal muscle. Journal of Physiology, 572, 281-294.
 Mackrell, J.G. and Cartee, G.D. (2012) A novel method to measure glucose uptake and myosin heavy chain isoform expression of single fibers from rat skeletal muscle. Diabetes, 61, 995-1003.
 Folland, J.P. and Williams, A.G. (2007) The adaptations to strength training: morphological and neurological contributions to increased strength. Sports Medicine, 37, 145- 168.
 Fry, A.C. (2004) The role of resistance exercise intensity on muscle fibre adaptations. Sports Medicine, 34, 663- 679.
 Thornell, L.E., Lindström, M., Renault, V., Mouly, V. and Butler-Browne, G.S. (2003) Satellite cells and training in the elderly. Scandinavian Journal of Medicine and Science in Sports, 13, 48-55.
 Hawke, T.J. and Garry, D.J. (2001) Myogenic satellite cells: Physiology to molecular biology. Journal of Applied Physiology, 91, 534-551.
 Ishido, M., Uda, M., Kasuga, N. and Masuhara, M. (2009) The expression patterns of Pax7 in satellite cells during overload-induced rat adult skeletal muscle hypertrophy. Acta Physiologica, 195, 459-469.
 Zammit, P.S., Golding, J.P., Nagata, Y., Hudon, V., Partridge, T.A. and Beauchamp, J.R. (2004) Muscle satellite cells adopt divergent fates a mechanism for self-renewal? The Journal of Cell Biology, 166, 347-357.
 Carson, J.A., Nettleton, D. and Reecy, J.M. (2002) Differential gene expression in the rat soleus muscle during early work overload-induced hypertrophy. Official Publication of the Federation of American Societies for Experimental Biology/FASEB Journal, 16, 207-209.
 Hespel, P., Op’t Eijnde, B., van Leemputte, M., Ursø, B., Greenhaff, P.L., Labarque, V., Dymarkowski, S., van Hecke, P. and Richter, EA. (2001) Oral creatine supplementation facilitates the rehabilitation of disuse atrophy and alters the expression of muscle myogenic factors in humans. Journal of Physiology, 536, 625-633.
 Philippou, A., Papageorgiou, E., Bogdanis, G., Halapas, A., Souria, A., Maridaki, M., Pissimissis, N. and Koutsilieris, M. (2009) Expression of IGF-1 isoforms after exercise-induced muscle damage in humans: Characterization of the MGF E peptide action in vitro. In Vivo, 23, 567-575.
 Allen, D.L., Roy, R.R. and Edgerton, V.R. (1999) Myonuclear domains in muscle adaptation and disease. Muscle & Nerve, 22, 1350-1360.
 Seene, T., Pehme, A., Alev, K., Kaasik, P., Umnova, M. and Aru, M. (2010) Effects of resistance training on fast- and slow-twitch muscles in rats. Biology of Sport, 27, 221-229.
 Hunter, G.R., McCarthy, J.P. and Bamman, M.M. (2004) Effects of resistance training on older adults. Sports Medicine, 34, 329-348.
 Cheek, D.B. (1985) The control of cell mass and replication. The DNA unit—A personal 20-year study. Early Human Development, 12, 211-239.
 Hall, Z.W. and Ralston, E. (1989) Nuclear domains in muscle cells. Cell, 59, 771-772.
 Kadi, F., Schjerling, P., Andersen, L.L., Charifi, N., Madsen, J.L.,Christensen, L.R. and Andersen, J.L. (2004) The effects of heavy resistance training and detraining on satellite cells in human skeletal muscles. Journal of Physiology, 558, 1005-1012.
 Baldwin, K.M. and Haddad, F. (2002) Skeletal muscle plasticity: Cellular and molecular responses to altered physical activity paradigms. American Journal of Physical Medicine and Rehabilitation, 81, S40-S51.
 Holloszy, J.O. and Booth, F.W. (1976) Biochemical adaptations to endurance exercise in muscle. Annual Review of Physiology, 38, 273-291.
 Hood, D.A. (2001) Invited review: Contractile activity- induced mitochondrial biogenesis in skeletal muscle. Journal of Applied Physiology, 90, 1137-1157.
 Seene, T., Kaasik, P. and Alev, K. (2011) Muscle protein turnover in endurance training: A review. The International Journal of Sports Medicine, 32, 905-911.
 Hood, D.A. (2009) Mechanisms of exercise-induced mitochondrial biogenesis in skeletal muscle. Applied Physiology, Nutrition, and Metabolism, 34, 465-472.
 Van Wessel, T., de Haan, A., van der Laarse, W.J., Jaspers, R.T. (2010) The muscle fiber type-fiber size paradox: Hypertrophy or oxidative metabolism? European Journal of Applied Physiology, 110, 665-694.
 Moore, D.R., Atherton, P.J., Rennie, M.J., Tarnopolsky, M.A. and Phillips, S.M. (2011) Resistance exercise enhances mTOR and MAPK signalling in human muscle over that seen at rest after bolus protein ingestion. Acta Physiologica, 201, 365-372.
 Bodine, S.C., Stitt, T.N., Gonzalez, M., Kline, W.O., Stover, G.L., Bauerlein, R., Zlotchenko, E., Scrimgeour, A., Lawrence, J.C., Glass, D.J. and Yancopoulos, G.D. (2001) Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo. Nature Cell Biology, 3, 1014-1019.
 Stitt, T.N., Drujan, D., Clarke, B.A., Panaro, F., Timofeyva, Y., Kline, W.O., Gonzalez, M., Yancopoulos, G.D. and Glass, D.J. (2004) The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors. Molecular Cell, 14, 395-403.
 Lee, S.J. and McPherron, A.C. (2001) Regulation of myostatin activity and muscle growth. Proceedings of the National Academy of Sciences of the United States of America, 98, 9306-9311.
 Zimmers, T.A., Davies, M.V., Koniaris, L.G., Haynes, P., Esquela, A.F., Tomkinson, K.N., McPherron, A.C., Wolfman, N.M. and Lee. S.-J. (2002) Induction of cachexia in mice by systemically administered myostatin. Science, 296, 1486-1488.
 Van der Vusse, G.J., Glatz, J.F., Stam, H.C. and Reneman, R.S. (1992) Fatty acid homeostasis in the normoxic and ischemic heart. Physiological Reviews, 72, 881-940.
 Seene, T. and Umnova, M. (1992) Relations between the changes in the turnover rate of contractile proteins, activation of satellite cells and ultra-structural response of neuromuscular junctions in the fast-oxidative-glucolytic muscle fibres in endurance trained rats. BAM, 2, 39-46.
 Harris, B.A. (2005) The influence of endurance and resistance exercise on muscle capillarization in the elderly: A review. Acta Physiologica Scandinavica, 185, 89-97.
 Yeo,W.K., Paton, C.D., Garnham, A.P., Burke, L.M., Carey, A.L. and Hawley, J.A. (2008) Skeletal muscle adaptation and performance responses to once a day versus twice every second day endurance training regimens. Journal of Applied Physiology, 105, 1462-1470.
 Hardie, D.G. and Sakamoto, K. (2006) AMPK: A key sensor of fuel and energy status in skeletal muscle. Physiology, 21, 48-60.
 McGee, S.L., Kristy, J., Mustard, D., Hardie, D.G. and Baar, K. (2008) Normal hypertrophy accompanied by phosphoryation and activation of AMP-activated protein kinase α1 following overload in LKB1 knockout mice. The Journal of Physiology, 586, 1731-1741.
 Sjöström, M., Johansson, C. and Lorentzon, R. (1988) Muscle pathomorphology in m. quadericeps of marathon runners. Early signs of strain disease or functional adaptation? Acta Physiolpgica Scandinavica, 132, 537-541.
 Spiering, B.A., Kraemer, W.J., Anderson, J.M., Armstrong, L.E., Nidl, B.C., Volek, J.S. and Maresh, C.M. (2008) Resistance exercise biology: Manipulation of resistance exercise programme variables determines the responses of cellular and molecular signalling pathways. Sports Medicine, 38, 527-540.
 Schoenfeld, B.J. (2012) Does exercise-induced muscle damage play a role in skeletal muscle hypertrophy? Journal of Strength and Conditioning Research, 26, 1441- 1453.
 Fell, J.W. and Williams, A.D. (2008) The effect of aging on skeletal-muscle recovery from exercise: Possible implications for the aging athlete. Journal of Aging and Physical Activity, 16, 97-115.
 Winder, W.W. and Hardie, D.G. (1996) Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise. The American Journal of Physiology, 270, E299-E304.
 Alev, K., Kaasik, P., Pehme, A., Aru, M., Parring. A.-M., Elart, A. and Seene, T. (2009) Physiological role of myosin light and heavy chain isoforms in fast- and slow- twitch muscles: Effect of exercise. Biology of Sport, 26, 215-234.
 Pehme, A., Alev, K., Kaasik, P., Julkunen, A. and Seene, T. (2004) The effect of mechanical loading on the MyHC synthesis rate and composition in rat plantaris muscle. The International Journal of Sports Medicine, 25, 332- 338.
 Pette D. (2001) Historical perspectives: Plasticity of mammalian skeletal muscle. Journal of Applied Physiology, 90, 1119-1124.
 Hernandez, J.M., Fedele, M.J. and Farrell, P.A. (2000) Time course evaluation of protein synthesis and glucose uptake after acute resistance exercise in rats. Journal of Applied Physiology, 88, 1142-1149.
 Seene, T., Kaasik, P., Alev, K., Pehme, A. and Riso, E.M. (2004) Composition and turnover of contractile proteins in volume-overtrained skeletal muscle. The International Journal of Sports Medicine, 25, 438-445.
 Foster, C., Synder, A. and Welsh, R. (1999) Monitoring of training, warm up, and performance in athletes. In: Lehmann, M., Foster, C., Gastmann, U., Keizer, H. and Steinacker, J.M., Eds., Overload, Performance Incompetence, and Regeneration in Sport, Kluwer-Academic/ Plenum Press, New York, 43-51.
 Lehmann, M., Gastmann, U., Baur, S., Liu, Y., Lormes, W., Opitz-Gress, A., Reisnecker, S., Simsch, C. and Steinacker, J.M. (1999) Selected parameters and mechanisms of peripheral and central fatigue and regeneration in overtrained athletes. In: Lehmann, M., Foster, C., Gastmann, U., Keizer, H. and Steinacker, J.M., Eds., Overload, Performance Incompetence, and Regeneration in Sport, Kluwer-Academic/Plenum Press, New York, 7-25.
 Kaasik, P. and Seene, T. (2010) The overtraining syndrome: Reflexion in skeletal muscle. Gazzetta Medica Italiana Archivio per le Scienze Mediche, 169, 311-319.
 Seene, T., Umnova, M. and Kaasik, P. (1999) The exercise myopathy. In: Lehmann, M., Foster, C., Gastmann, U., Keizer, H. and Steinacker, J.M., Eds., Overload, Performance Incompetence, and Regeneration in Sport, Kluwer Academic Plenum Publishers, New York, 119-130.
 Xiao, W. and Dong, C.J. (2012) Effect of overtraining on skeletal muscle growth and gene expression. The International Journal of Sports Medicine, 33, 846-853.
 Moldoveanu, A.I., Shephard, R.J. and Shek, P.N. (2001) The cytokine response to physical activity and training. Sports Medicine, 31, 115-144.
 Smith, L.L. (2000) Cytokine hypothesis of overtraining: A physiological adaptation to excessive stress? Medicine and Science Sports and Exercise, 32, 317-331.
 Wills, K.S., Smith, D.T., Broughton, K.S. and Larson- Meyer, D.E. (2012) Vitamin D status and biomarkers of inflammation in runners. Open Access Journal of Sports Medicine, 3, 35-42.
 Salo, D.C., Donovan, C.M. and Davies, K.J. (1991) HSP70 and other possible heat shock or oxidative stress proteins are induced in skeletal muscle, heart, and liver during exercise. Free Radical Biology and Medicine, 11, 239-246. doi:10.1016/0891-5849(91)90119-N
 Guglielmo, C.G., Piersma, T. and Williams, T.D. (2001) A sport-physiological perspective on bird migration: Evidence for flight-induced muscle damage. The Journal of Experimental Biology, 204, 2683-2690.
 Liu, Y. and Steinacker, J.M. (2001) Changes in skeletal muscle heat shock proteins: Pathological significance. Frontiers in Bioscience, 6, D12-25. doi:10.2741/Liu
 Steinacker, J.M. and Liu, Y. (2002) Stress proteins and applied exercise physiology. In: Locke, M. and Noble, E.G., Eds., Exercise and Stress Response: The Role of Stress Proteins, CRC Press, Boca Raton, 197-216.
 Kurek, J.B., Bower, J.J., Romanella, M., Koentgen, F., Murphy, M. and Austin, L. (1997) The role of leukaemia inhibitory factor in skeletal muscle regeneration. Muscle & Nerve, 20, 815-822.
 Moresi, V., Pristerá, A., Scicchitano, B.M., Molinaro, M., Teodori, L., Sassoon, D., Adamo, S. and Coletti, D. (2008) Tumor necrosis factor-alpha inhibition of skeletal muscle regeneration is mediated by a caspase-dependent stem cell response. Stem Cells, 26, 997-100.
 Bhatnagar, S., Panguluri, S.K., Gupta, S.K., Dahiya, S., Lundy, R.F. and Kumar, A. (2010) Tumor necrosis factor-α regulates distinct molecular pathways and gene networks in cultured skeletal muscle cells. PLoS ONE, 5, e13262. doi:10.1371/journal.pone.0013262
 Schleithoff, S.S., Zittermann, A., Tenderich, G., Berthold, H., Stehle, P. and Koerfer, R. (2006) Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure: A double-blind, randomized, placebo-controlled trial. The American Journal of Clinical Nutrition, 83, 754-759.
 Peterson, C.A. and Heffernan, M.E. (2008) Serum tumor necrosis factor-alpha concentrations in healthy women. Journal of Inflammation, 5, 10.
 Shea, M.K., Booth, S.L., Massaro, J.M., Jacques, P.F., D’Agostino, R.B., Dawson-Hughes, B., Ordovas, J.M., O’Donnell, C.J., Kathiresan, S., Keaney, J.F., Vasan, R.S. and Benjamin, E.J. (2008) Vitamin K and vitamin D status: Associations with inflammatory markers in the Framingham offspring study. American Journal of Epidemiology, 167, 313-320.
 Lowery, L. and Forsythe, C.E. (2006) Protein and overtraining: Potential applications for free-living athletes. Journal of the International Society of Sports Nutrition, 3, 42-50.
 Long, C.L., Schaffel, N., Geiger, J.W., Schiller, W.R. and Blakemore, W.S. (1979) Metabolic response to injury and illness: Estimation of energy and protein needs from indirect calorimetry and nitrogen balance. Journal of Parenteral and Enteral Nutrition, 3, 452-456.
 Williams, M. (2005) Nutrition for health fitness and sport. McGrow-Hill Publishing Company, Boston.
 Ament, W. and Verkere, G.J. (2009) Exercise and fatigue. Sports Medicine, 39, 389-422.
 Neto, J.C.R., Lira, F.S., Oyama, L.M., Zanchi, N.E., Yamashita, A.S., Batista, M.L., Oller do Nascimento, C.M. and Seelaender, M. (2009) Exhaustive exercise causes an anti-inflammatory effect in skeletal muscle and a pro-inflammatory effect in adipose tissue in rats. European Journal of Applied Physiology, 106, 697-704.