Dynamical modelling of cardiac electrical activity using bidomain approach: The effects of variation of ionic model parameters

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This work presents the dynamical modelling of cardiac electrical
activity using bidomain approach. It focuses on the effects of variation of the
ionic model parameters on cardiac wave propagation. Cardiac electrical
activity is governed by partial differential equations coupled to a system of
ordinary differential equations. Numerical simulation of these equations is computationally expensive due to their non-linearity and stiffness. Nevertheless, we
adopted the bidomain model due to its ability to reflect the actual cardiac
wave propagation. The derived bidomain equations coupled with FitzHugh-Nagumo’s
ionic equations were time-discretized using explicit forward Euler method and
space-discretized using 2-D network modelling to obtain linearized equations
for transmembrane potential *V _{m}*,
extracellular potential

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