Center of Clinical and Experimental medical, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk, Russia.
In the course of the study there were examined cytokine levels of pro-inflammatory and anti-inflammatory activity (IL-1b, IL-4, IL-6, IL-8, IL-10, IFN-g, G-GSF), and also the levels of progesterone and estradiol in the blood serum with a view to study the pathogenic characteristics of a chronic inflammatory process of the pelvic organs in remission. It was shown that the remission of the disease is characterized by the significant increase in the concentrations of pro-inflammatory cytokines IL-6, IL-8, and also increase of inducers activation of the immune response of the immune response (IL-4 and IFN-g), accompanied by a decrease in the concentration of sex hormones. In women with chronic inflammatory diseases of urogenital sphere in remission tested active immunological process and violation of the synthesis of sex hormones. Revealed changes predispose to the emergence disorders of reproductive health.
Trunov, A. , Obukhova, O. , Gorbenko, O. , Shvayk, A. and Trunova, L. (2013) Cytokines, estradiol and progesterone in the plasma of women of reproductive age with pelvic inflammatory disease in remission. Advances in Bioscience and Biotechnology, 4, 727-730. doi: 10.4236/abb.2013.46096.
[1] Kondranina T.G., Gorin V.S. and Grigoriev E.V. (2009), Acute-phase proteins and markers of endotoxemia, and their prognostic value in gynecological practice. Russian Journal of Obstetrician and Gynecologist, 9, 26-30. [2] Smith, M., Hagerty, K.A., Skipper, B. and Bocklage, T. (2010) Chronic endometritis: A combined histopathologic and clinical review of cases from 2002 to 2007. International Journal of Gynecological Pathology, 1, 44-50. doi:10.1097/PGP.0b013e3181ae81bb [3] Frolov, M.V. and Khalim H. (2006) Evaluation of the reproductive function of women with acute and chronic inflammatory diseases of the uterus. Journal of Voronezh, 7, 21-26. [4] Mardh, P.A. (2004) Tubal factor infertility, with special regard to chlamydial salpingitis. Current Opinion in Infectious Diseases, 1, 49-52. doi:10.1097/00001432-200402000-00010 [5] Gorin, V.S., Saginor, M.E., Maltiyskaya, N.A., Birjukova, L.A. and Maltiysky, M.L. (2008) Principles of diagnosis and treatment of purulent inflammatory diseases of the uterus. Russian Journal of Obstetrician and Gynecologist, 5, 30-38. [6] Trunovа, L.A., Gorbenko, O.M., Shvayk, A.P., Obukhovа, O.O., Anisimova, N.I., Chernikh, V.V., Safronov, I.D. and Trunov A.N. (2008) Active immunological process in women of reproductive age with chronic infectious and inflammatory diseases of the uterus in clinical remission. Bulletin of SO RAMS, 1, 80-83. [7] Strijakov, A.N., Kargamanova, J.A. and Yakubovich, D.V. (2004) Clinical and immunological study of therapy in patients with acute inflammation of the uterus. Questions of Gynecology, Obstetrics and Perinatology, 3, 26-29. [8] Lee, S.A., Tsai, H.T., Ou, H.C., Han, C.P., Tee, Y.T., Chen, Y.C., Wu, M.T., Chou, M.C., Wang, P.H. and Yang, F. (2008) Plasma interleukin-1beta, -6, -8 and tumor necrosis factor-alpha as highly informative markers of pelvic inflammatory disease. Clinical Chemistry and Laboratory Medicine, 7, 997-1003. [9] Ng, S.C., Gilman-Sachs, A. and Thaker, P. (2002) Expression of intracellular Th1 and Th2 cytokines in women with recurrent spontaneous abortion, implantation failures after IVF/ET or normal pregnancy. American Journal of Reproductive Immunology, 2, 77-86. doi:10.1034/j.1600-0897.2002.01105.x [10] Chen, K.S., Wang, P.H., Yang, S.F., Lin, D.B., Lin, Y.J., Kuo, D.Y., Lin, L.Y., Wu, M.T., Lin, C.W., Lee, S, Chou, M.C., Tsai, H.T. and Hsieh, Y.S. (2008) Significant elevation of a Th2 cytokine, interleukin-10, in pelvic inflammatory disease. Clinical Chemistry and Laboratory Medicine, 11, 1609-1616. [11] Trunov, A.N., Efremov, A.V. and Trunova, L.A. (2002) Principles pathogenetically substantiated diagnosis in therapies of chronic infectious and inflammatory diseases. Allergology and Immunology, 1, 117.