Associations of polymorphisms in rs4646903 site of CYP1A1 and rs1056836 site of CYP1B1 genes with the breast cancer (BC) were studied in two main ethnic groups of Kazakhstan Republic (Kazakhs and Russians). Total number of BC patients was 181, controls—397. The statistically significant differences were revealed in allele frequencies (χ2=5.93, р=0.004) and in genotypes distribution (χ2=8.71, р=0.015) in rs4646903 site of CYP1A1 gene in Kazakh but not in Russian group. The study of CYP1В1 rs1056836 site demonstrated differences in genotype distributions (χ2=7.48, р=0.023) between BC patients and controls in Russian but not in Kazakh ethnic group.
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Balmukhanov, T. , Khanseitova, A. , Nigmatova, V. , Varchenko, S. , Talaeva, S. and Aitkhozhina, N. (2013) Associations of Polymorphisms of the CYP1A1 and CYP1B1 Cytochrome P450 Genes with Breast Cancer in Kazakhstan. Advances in Breast Cancer Research, 2, 51-55. doi: 10.4236/abcr.2013.23009.
 V. Paracchini, S. Raimondi, I. T. Gram, D. Kang, N. A. Kocabas, V. N. Kristensen, D. Li, F. F. Parl, T. Rylander-Rudqvist, P. Soucek, W. Zheng, S. Wedren and E. Taioli, “Metaand Pooled Analyses of the Cytochrome P-450 1B1 Val432Leu Polymorphism and Breast Cancer: A HuGE-GSEC Review,” American Journal of Epidemiology, Vol. 165, No. 2, 2007, pp. 115-125.
 K. W. Reding, C. Chen, K. Lowe, D. R. Doody, C. S. Carlson, C. T. Chen, J. Houck, L. K. Weiss, P. A. Marchbanks, L. Bernstein, R. Spirtas, J. A. McDonald, B. L. Strom, R. T. Burkman, M. S. Simon, J. M. Liff, J. R. Daling and K. E. Malone, “Estrogen-Related Genes and Their Contribution to Racial Differences in Breast Cancer Risk,” Cancer Causes Control, Vol. 23, No. 5, 2012, pp. 671-681. doi:10.1007/s10552-012-9925-x
 L. F. Gulyaeva, O. N. Mikhailova, V. O. Pustylnyak, I. V. Kim, A. V. Gerasimov, S. E. Krasilnikov, M. L. Filipenko and E. V. Pechkovsky, “Comparative Analysis of SNP in Estrogen-Metabolizing Enzymes for Ovarian, Endometrial, and Breast Cancers in Novosibirsk, Russia,” Advanced Experimental and Medical Biology, Vol. 617, 2008, pp. 359-366. doi:10.1007/978-0-387-69080-3_34
 G. F. Korytina, L. Z. Akhmadishina, O. V. Kochetova, Sh. Z. Zagidullin and T. V. Viktorova, “Association of Cytochrome P450 Genes Polymorphisms (CYP1A1 and CYP1A2) with the Development of Chronic Obstructive Pulmonary Disease in Bashkortostan,” Molecular Biology, Vol. 42, No. 1, 2008, pp. 32-41.
 M. T. Wu, J. M. Lee, D. C. Wu, C. K. Ho, Y. T. Wang, Y. C. Lee, H. K. Hsu and E. L. Kao, “Genetic Polymorphisms of Cytochrome P4501A1 and Oesophageal SquamousCell Carcinoma in Taiwan,” British Journal of Cancer, Vol. 87, No. 5, 2002, pp. 529-532.
 M. Sasaki, Y. Tanaka, M. Kaneuchi, N. Sakuragi and R. Dahiya, “CYP1B1 Gene Polymorphisms Have Higher Risk for Endometrial Cancer, and Positive Correlations with Estrogen Receptor Alpha and Estrogen Receptor Beta Expressions,” Cancer Research, Vol. 63, No. 14, 2003, pp. 3913-3918.
 C. Kiyohara, T. Horiuchi, K. Takayama and Y. Nakanishi, “Genetic Polymorphisms Involved in Carcinogen Metabolism and DNA Repair and Lung Cancer Risk in a Japanese Population,” Journal of Thoracic Oncology, Vol. 7, No. 6, 2012, pp. 954-962.
 D. Wang, M. Su, D. Tian and S. Liang, “Associations between CYP1A1 and CYP2E1 Polymorphisms and Susceptibility to Esophageal Cancer in Chaoshan and Taihang Areas of China,” Cancer Epidemiology, Vol. 36, No. 3, 2012, pp. 276-282. doi:10.1016/j.canep.2011.10.008
 T. N. Sergentanis, K. P. Economopoulos, S. Choussein and N. F. Vlahos, “Cytochrome P450 1A1 (CYP1A1) Gene Polymorphisms and Cervical Cancer Risk: A Meta-Analysis,” Molecular Biology Reports, Vol. 39, No. 6, 2012, pp. 6647-5654. doi:10.1007/s11033-012-1470-x
 J. R. Long, Q. Cai, X. O. Shu, H. Cai, Y. T. Gao and W. Zheng, “Genetic Polymorphisms in Estrogen-Metabolizing Genes and Breast Cancer Survival,” Pharmacogenetical Genomics, Vol. 17, No. 5, 2007, pp. 331-338.
 A. Shin, D. Kang, J. Y. Choi, K. M. Lee, S. K. Park, D. Y. Noh, S. H. Ahn and K. Y. Yoo, “Cytochrome P450 1A1 (CYP1A1) Polymorphisms and Breast Cancer Risk in Korean Women,” Experimental & Molecular Medicine, Vol. 39, No. 3, 2007, pp. 361-366.
 B. Diergaarde, J. D. Potter, E. R. Jupe, S. Manjeshwar, C. D. Shimasaki, T. W. Pugh, D. C. Defreese, B. A. Gramling, I. Evans and E. White, “Polymorphisms in Genes Involved in Sex Hormone Metabolism, Estrogen plus Progestin Hormone Therapy Use, and Risk of Postmenopausal Breast Cancer,” Cancer Epidemiology, Biomarkers and Prevention, Vol. 17, No. 7, 2008, pp. 1751-1759.
 M. Moreno-Galván, N. E. Herrera-González, V. RoblesPérez, J. C. Velasco-Rodríguez, R. Tapia-Conyer and E. Sarti, “Impact of CYP1A1 and COMT Genotypes on Breast Cancer Risk in Mexican Women: A Pilot Study,” International Journal of Biological Markers, Vol. 25, No. 3, 2010, pp. 157-163.
 E. P. Khvostova, V. O. Pustylnyak and L. F. Gulyaeva, “Genetic Polymorphism of Estrogen Metabolizing Enzymes in Siberian Women with Breast Cancer,” Genetic Testing and Molecular Biomarkers, Vol. 16, No. 3, 2012, pp. 167-173. doi:10.1089/gtmb.2011.0131
 N. A. Ajtkhozhina, V. G. Nigmatova, A. K. Khanseitova, M. A. Mendesh, E. E. Ashirbekov and T. S. Balmukhanov, “Polymorphic Markers of Some Genes Associated with Multiple Sclerosis in the Population of Kazakhstan,” Genetika, Vol. 47, No. 6, 2011, pp. 847-852.
 H. Jiao, C. Liu, W. Guo, L. Peng, Y. Chen and F. L. Martin, “Association of CYP1B1 Polymorphisms with Breast Cancer: A Case-Control Study in the Han Population in Ningxia Hui Autonomous Region, P. R. China,” Biomark Insights, Vol. 12, 2010, pp. 21-27.
 W. Zheng, D. W. Xie, F. Jin, J. R. Cheng, Q. Dai, W. Q. Wen, X. O. Shu and Y. T. Gao, “Genetic Polymorphism of Cytochrome P450-1B1 and Risk of Breast Cancer,” Cancer Epidemiology, Biomarkers and Prevention, Vol. 9, No. 2, 2000, pp. 147-150.
 N. A. Kocabas, S. Sardas, S. Cholerton, A. K. Daly and A. E. Karakaya, “Cytochrome P450 CYP1B1 and Catechol OMethyltransferase (COMT) Genetic Polymorphisms and Breast Cancer Susceptibility in a Turkish Population,” Archives of Toxicology, Vol. 76, No. 11, 2002, pp. 643-649. doi:10.1007/s00204-002-0387-x
 M. N. Okobia, C. H. Bunker, S. J. Garte, J. M. Zmuda, E. R. Ezeome, S. N. Anyanwu, E. E. Uche, U. Osime, J. Ojukwu, L. H. Kuller, R. E. Ferrell and E. Taioli, “Cytochrome P450 1B1 Val432Leu Polymorphism and Breast Cancer Risk in Nigerian Women: A Case Control Study,” Infection Agent Cancer, Vol. 10, No. 4, 2009, pp. S1-S12.
 P. Sillanpaa, L. Heikinheimo, V. Kataja, M. Eskelinen, V. M. Kosma, M. Uusitupa, H. Vainio, K. Metsola and A. Hirvonen, “CYP1A1 and CYP1B1 Genetic Polymorphisms, Smoking and Breast Cancer Risk in a Finnish Caucasian Population,” Breast Cancer Research and Treatment, Vol. 104, No. 3, 2007, pp. 287-297.
 J. Z. Cerne, M. Pohar-Perme, S. Novakovic, S. Frkovic-Grazio, V. Stegel and K. Gersak, “Combined Effect of CYP1B1, COMT, GSTP1, and MnSOD Genotypes and Risk of Postmenopausal Breast Cancer,” Journal of Gynecologic Oncology, Vol. 22, No. 2, 2011, pp. 110-119.
 A. J. Sigurdson, P. Bhatti, S. C. Chang, P. Rajaraman, M. M. Doody, L. Bowen, S. L. Simon, R. M. Weinstock, M. S. Linet, M. Rosenstein, M. Stovall, B. H. Alexander, D. L. Preston and J. P. Struewing, “Polymorphisms in Estrogen Biosynthesis and Metabolism-Related Genes, Ionizing Radiation Exposure, and Risk of Breast Cancer among US Radiologic Technologists,” Breast Cancer Research and Treatment, Vol. 118, No. 1, 2009, pp. 177-184.
 K. M. Lee, J. Abel, Y. Ko, V. Harth, W. Y. Park, J. S. Seo, K. Y. Yoo, J. Y. Choi, A. Shin, S. H. Ahn, D. Y. Noh, A. Hirvonen and D. Kang, “Genetic Polymorphisms of Cytochrome P450 19 and 1B1, Alcohol Use, and Breast Cancer Risk in Korean Women,” British Journal of Cancer, Vol. 88, No. 5, 2003, pp. 675-678.
 N. Shimada, M. Iwasaki, Y. Kasuga, S. Yokoyama, H. Onuma, H. Nishimura, R. Kusama, G. S. Hamada, I. N. Nishimoto, H. Iyeyasu, J. Motola Jr., F. M. Laginha, N. Kurahashi and S. Tsugane, “Genetic Polymorphisms in Estrogen Metabolism and Breast Cancer Risk in Case-Control Studies in Japanese, Japanese Brazilians and Non-Japanese Brazilians,” Human Genetics, Vol. 54, No. 4, 2009, pp. 209-215. doi:10.1038/jhg.2009.13