ABSTRACT Background:Maternal periodontal infection has been proposed to influence pre-term delivery and low birth weight infants through mechanisms involving inflammatory mediators or direct bacterial assault on the amnion. Thus, the aim of the present study was to assess the presence of periodontal pathogens in maternal periodontal infection and their effect on the birth weight of infants.Materials and Methods: The case-control study included 30 mothers with a singleton gestation and gestational age of >37 weeks. Data regarding the periodontal status, pregnancy outcome variables, hemoglobin levels (Hb%) and other factors that may influence adverse pregnancy outcomes were collected. A qualitative analysis of the predominant anaerobic organisms was conducted. The data was analysed using one-way ANOVA test and Scheffe’s test.Results: The microbiological results showed that prevalent colonies of organisms isolated from the experimental groups were of Bacteroides spp. (n = 3), Fusobacterium spp. (n = 3) and Peptostreptococcus spp. (n = 9). In the control group, Peptostreptococcus spp. (n = 15) were predominant. In the experimental group, it was seen that Bacteroides spp. (p = 0.003) and Fusobacterium spp. (p = 0.050) were statistically significant with the birth weight of the infant. The one-way ANOVA test showed that the birth weight of the infant was inversely proportionate with increase in severity of the periodontal disease. Scheffe’s test showed that presence of a periodontal pocket showed most significance to the birth weight of an infant as compared to presence of local factors or bleeding on probing.Conclusion: The study revealed that the gram negative organisms, Bacteroides spp. and Fusobacterium spp. were significantly associated with the low birth weight (LBW) of the infants, although there was not a significant difference in the clinical periodontal status between the experimental groups and the controls. It could be proposed that specific groups of pathogens may have a contributory role in the risk of LBW.
Cite this paper
S. Kothiwale and M. Gandhi, "Effect of Periodontal Infection on Birth Weight of Infants: A Clinical and Microbiological Study*," Open Journal of Medical Microbiology, Vol. 3 No. 2, 2013, pp. 100-104. doi: 10.4236/ojmm.2013.32016.
 UNICEF & WHO, “Low Birthweight: Country, Regional and Global Estimates,” UNICEF, 2004.
 United Nations Development Programme Human Development Report, 2005.
 M. K. Sharma, D. Kumar, A. Huria and P. Gupta, “Maternal Risk Factors of Low Birth Weight in Chandigarh India,” The Internet Journal of Health, Vol. 9, No. 1, 2009.
 World Health Organization, “The Incidence of Low Birth Weight: An Update,” Weekly Epidemiological Record, Vol. 59, 1984, pp. 205-211.
 S. Offenbacher, V. Katz, G. Fertik, J. Collins, D. Boyd and G. Maynor, “Periodontal Infection as a Possible Risk Factor for Preterm Low Birth Weight,” Journal of Periodontology, Vol. 67, No. 10s, 1996, pp. 1103-1113.
 S. Offenbacher, H. L. Jared, P. G. O’Reilly, et al., “Potential Pathogenic Mechanisms of Periodontitis Associated Pregnancy Complications,” Annals of Periodontology, Vol. 3, No. 1, 1998, pp. 233-250.
 C. M. Champagne, P. N. Madianos, S. Lieff, et al., “Periodontal Medicine: Emerging Concepts in Pregnancy Outcomes,” Journal of the International Academy of Periodontology, Vol. 2, No. 1, 2000, pp. 9-13.
 F. A. Scannapieco, R. B. Bush and S. Paju, “Periodontal Disease as a Risk Factor for Adverse Pregnancy Outcomes. A Systematic Review,” Annals of Periodontology, Vol. 8, No. 1, 2003, pp. 70-78.
 X. Xiong, P. Buekens, W. D. Fraser, J. Beck and S. Offenbacher, “Periodontal Disease and Adverse Pregnancy Outcomes: A Systematic Review,” BJOG: An International Journal of Obstetrics & Gynaecology, Vol. 113, No. 2, 2006, pp. 135-143.
 R. C. Page and K. S. Kornman, “The Pathogenesis of Human Periodontitis: An Introduction,” Periodontology, Vol. 14, No. 1, 2000, pp. 9-11.
 J. A. McGregor, J. I. French, R. Richter, et al., “Antenatal Microbiologic and Maternal Risk Factors Associated with Prematurity,” American Journal of Obstetrics & Gynecology, Vol. 163, No. 5, 1990, pp. 1465-1473.
 J. G. Collins, M. A. Smith, R. R. Arnold and S. Offenbacher, “Effects of Escherichia coli and Porphyromonas gingivalis Lipopolysaccharides on Pregnancy Outcome in the Golden Hamster,” Infection and Immunity, Vol. 62, No. 10, 1994, pp. 4652-4655.
 D. Mitchell-Lewis, S. P. Engebretson, J. Chen, I. B. Lamster and P. N. Papapanou, “Periodontal Infections and Pre-Term Birth: Early Findings from a Cohort of Young Minority Women in New York,” European Journal of Oral Sciences, Vol. 109, No. 1, 2001, pp. 34-39.
 H. Minkoff, A. N. Grunebaum, R. H. Schwarz, et al., “Risk Factors for Prematurity and Premature Rupture of Membranes: A Prospective Study of the Vaginal Flora in Pregnancy,” American Journal of Obstetrics & Gynecology, Vol. 150, No. 8, 1984, pp. 965-972.
 J. A. McGregor, J. I. French, D. Lawellin, et al., “Bacterial Protease-Induced Reduction of Chorioamniotic Membrane Strength and Elasticity,” Obstetrics & Gynecology, Vol. 69, No. 2, 1987, pp. 167-174.
 J. Katz, N. Chegini, K. T. Shiverick and R. J. Lamont, “Localization of P. gingivalis in Preterm Delivery Placenta,” Journal of Dental Research, Vol. 88, No. 6, 2009, pp. 575-578. doi:10.1177/0022034509338032
 M. K. Jeffcoat, N. C. Geurs, M. S. Reddy, et al., “Periodontal Infections and Preterm Birth: Results of a Prospective Study,” Journal of Dental Research, Vol. 80, 2001, p. 956.
 K. Hasegawa-Nakamura, F. Tateishi, T. Nakamura, et al., “The Possible Mechanism of Preterm Birth Associated with Periodontopathic Porphyromonas gingivalis,” Journal of Periodontal Research, Vol. 46, No. 4, 2011, pp. 497-504. doi:10.1111/j.1600-0765.2011.01366.x
 N. Buduneli, H. Baylas, E. Buduneli, et al., “Periodontal Infections and Pre-Term Low Birth Weight: A Case-Control Study,” Journal of Clinical Periodontology, Vol. 32, No. 2, 2005, pp. 174-181.