Introduction: There is a growing demand for non-invasive methods with no down time and minimal risk for facial skin rejuvenation and treatment of wrinkles. The Maximus system, based on TriLipo technology, combines radiofrequency and Dynamic Muscle Activation (DMA). We evaluated the safety and efficacy of the MaximusTM system for the treatment of facial wrinkles. Methods: Twenty women received 8 weekly treatments for facial wrinkles using the Maximus system. Treatment efficacy was assessed by comparing pre- and post-treatment photographs, assessing skin characteristics using the 3D Visioscan system, assessing skin microtopography using the DUB ultrasonic scanning system, assessing microcirculation conditions of facial skin using Laser Doppler Flowmetry (LDF) and subjective evaluation of skin improvement. Results: No adverse events were observed. Following the treatments, positive changes in skin flakiness (scaliness), roughness, smoothness and wrinkles were demonstrated using Visioscan. A thickening of the epidermal-dermal layer and increased structural homogeneity were observed by ultrasound, hyperechogenicity was increased and areas of hypoechogenicity reduced. Microcirculation was improved, corresponding with a positive trend for improved skin characteristics. Conclusions: The Maximus system powered by the TriLipo technology is a non-invasive, effective, safe, and virtually painless treatment for reduction of wrinkles and facial skin rejuvenation.
 W. Manuskiatti, E. Boonthaweeyuwat and S. Varothai, “Treatment of Striae Distensae with a Tripollar Radiofrequency Device: A Pilot Study,” The Journal of Dermatological Treatment, Vol. 20, No. 6, 2009, pp. 354-364. doi:10.3109/09546630903085278
 W. Manuskiatti, C. Wachirakaphan, N. Lektrakul and S. Varothai, “Circumference Reduction and Cellulite Treatment with a Tripollar Radiofrequency Device: A Pilot Study,” Journal of the European Academy of Dermatology and Venereology, Vol. 23, No. 7, 2009, pp. 820-827. doi:10.1111/j.1468-3083.2009.03254.x
 H. Kaplan and A. Gat, “Clinical and Histopathological Results Following Tripollar Radiofrequency Skin Treatments,” Journal of Cosmetic Laser Therapy, Vol. 11, No. 2, 2009, pp. 78-84. doi:10.1080/14764170902846227
 S. Boisnic and M. C. Branchet, “Ex Vivo Human Skin Evaluation of Localized Fat Reduction and Anti-Aging Effect by TriPollar Radio Frequency Treatments,” Journal of Cosmetic Laser Therapy, Vol. 12, No. 1, 2010, pp. 25-31. doi:10.3109/14764170903376232