Back
 JCDSA  Vol.3 No.2 , June 2013
Evaluation of the Efficacy and Safety for Atopic Dry Skin of a Medicinal Moisturizing Lotion (Mentholatum AP Soft Medicinal Moisture Lotion) Prepared by a High-Pressure Emulsification Method
Abstract: In order to evaluate the efficacy and safety of Mentholatumò AP Soft Lotion (APA), which is a Vaseline-based preparation that has been converted to nanoparticles by high-pressure emulsification technology, we conducted a study of 4-week continuous use on the atopic dry skin of patients with minor to moderate atopic dermatitis (AD). The results showed that improvements in the skin findings (dryness and scaling) and itching were observed beginning one week after starting to apply APA and that the symptoms had almost completely resolved at 3 to 4 weeks after the start of application. In addition, a significant increase in the degree of high-frequency conductivity, which is an indicator of the amount of moisture in the stratum corneum, and significant decrease in transepidermal water loss (TEWL) were observed, and improvements in skin functions were observed. The results for overall degree of improvement showed “improvement” or better in 100% of the subjects, and no side effects were observed in any of the cases. Based on the above results, it was concluded that APA is a preparation that has excellent efficacy and safety as skin care for atopic dry skin, in which reduced stratum corneum function is observed in the skin, and as a supplemental method of treatment of AD or treatment method to maintain remissions.
Cite this paper: T. Omi and Y. Ochiai, "Evaluation of the Efficacy and Safety for Atopic Dry Skin of a Medicinal Moisturizing Lotion (Mentholatum AP Soft Medicinal Moisture Lotion) Prepared by a High-Pressure Emulsification Method," Journal of Cosmetics, Dermatological Sciences and Applications, Vol. 3 No. 2, 2013, pp. 145-150. doi: 10.4236/jcdsa.2013.32023.
References

[1]   M. Watanabe, et al., “Functional Analyses of the Superficial Stratum Corneum in Atopic Xerosis,” Archives of Dermatology, Vol. 127, No. 11, 1991, pp. 1689-1692.

[2]   K. Kikuchi, et al., “Evaluation of the Skin Surface Hydration for 0.15% Prednisolone Butylacetate ‘Mentholatum?AP Soft Lotion’ by High Pressure Emulsification Manufacturing Method and Effects and Safety in Patients with Atopic Dermatitis,” Japanese Journal of Medicine and Pharmaceutical Science, Vol. 58, No. 2, 2007, pp. 279-287.

[3]   I. Angelova-Fischer, et al., “The Objective Severity Assessment of Atopic Dermatitis (OSAAD) Score: Validity, Reliability and Sensitivity in Adult Patients with Atopic Dermatitis,” British Journal of Dermatology, Vol. 153, No. 4, 2005, pp. 767-773.

[4]   J. L. Sugarman, et al., “The Objective Severity Assessment of Atopic Dermatitis Score: An Objective Measure Using Permeability Barrier Function and Stratum Corneum Hydration with Computer-Assisted Estimates for Extent of Disease,” Archives of Dermatology, Vol. 139, No. 11, 2003, pp. 1417-1422. doi:10.1001/archderm.139.11.1417

[5]   H. Tagami, et al., “Evaluation of the Skin Surface Hydration in Vivo by Electrical Measurement,” Journal of Investigative Dermatology, Vol. 75, No. 6, 1980, pp. 500-507. doi:10.1111/1523-1747.ep12524316

 
 
Top