CWEEE  Vol.2 No.2 B , April 2013
Time-Effect Relationship of Toxicity Induced by Roundup® and Its Main Constituents in Liver of Carassius Auratus
ABSTRACT

In order to evaluate the eco-toxicological effects of Roundup&reg on Carassius auratus (C. auratus), fish were exposed to 32 μg/L Roundup&reg, isopropylamine salt of glyphosate (G.I.S) and polyoxyethylene amine (POEA) over different periods (0.5, 1, 3, 7 and 14 d). Hydroxyl radical (·OH), malondialdehyde (MDA) and acetylcholinesterase (AChE) in liver were detected in this study. Results showed that the generation of ·OH increased before 7 d, but without significantly difference. ·OH was induced at 1 d for POEA group, 3 d for Roundup&reg group and 7 d for G.I.S group. At 14 d, ·OH generation returned to normal levels. MDA contents all increased significantly (p < 0.01) during 7 days and then reached a normal level at 14 d. AChE activity in all group tests revealed a significant inhibition (p < 0.01) after 7 days exposure and then rebounded a little, but remained below the control after 14 days exposure. The rate of AChE inhibition range from 13% - 42% in Roundup&reg, 6% - 40% in G.I.S, and 21% - 54% in POEA, suggesting that POEA was more toxic compared to Roundup&reg and G.I.S. 32 μg/L Roundup&reg exposure led to the change of physiological and biochemical indexes in C. auratus, which was a reversible process in the long run.



Cite this paper
Fan, J. , Geng, J. , Ren, H. and Wang, X. (2013) Time-Effect Relationship of Toxicity Induced by Roundup® and Its Main Constituents in Liver of Carassius Auratus. Computational Water, Energy, and Environmental Engineering, 2, 20-25. doi: 10.4236/cweee.2013.22B004.
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