FNS  Vol.4 No.6 , June 2013
Antiproliferative Activity of “Lycopersicon esculentum” Leaves (Var. Paul Robenson): Preliminary Study
Abstract: Among plants, the Lycopersicon esculentum (Solanaceae) is the most important for its beneficial effects on health. Several epidemiological studies have shown the benefits of tomato consumption in the cancer and cardiovascular disease prevention. Tomato products constitute the major source of lycopene, the most potent antioxidant among carotenoids in vitro. In tomatoes leaves are also present many secondary metabolites including phenolic compounds, phytoalexins, protease inhibitors and glycoalkaloids who protect against adverse effects of hosts including fungi, bacteria, viruses, and insects and are involved in host-plant resistance. In this work we evaluated the antiproliferative activity of tomato leaves extract (var. Paul Robenson) in vitro.
Cite this paper: C. Saturnino, A. Spagnuolo, C. Palladino, A. Popolo, G. Tommonaro, R. Prisco and A. Pinto, "Antiproliferative Activity of “Lycopersicon esculentum” Leaves (Var. Paul Robenson): Preliminary Study," Food and Nutrition Sciences, Vol. 4 No. 6, 2013, pp. 632-635. doi: 10.4236/fns.2013.46081.

[1]   M. L. Balestrieri, R. De Prisco, B. Nicolaus, P. Pari, V. Schiano Moriello, G. Strazzullo, E. L. Iorio, L. Servillo and C. Balestrieri, “Lycopene in Association with Alpha-Tocopherol or Tomato Lipophilic Extracts Enhances AcylPlatelet-Activating Factor Biosynthesis in Endothelial Cells during Oxidative Stress,” Free Radical Biology & Medicine, Vol. 36, No. 8, 2004, pp. 1058-1067. doi:10.1016/j.freeradbiomed.2004.01.014

[2]   A. V. Rao, “Lycopene, Tomatoes, and the Prevention of Coronary Heart Disease,” Experimental Biology and Medicine, Vol. 227, No. 10, 2002, pp. 908-913.

[3]   A. Nahum, K. Hirsch, M. Danilenko, C. K. Watts, O. W. Prall, J. Levy and Y. Sharoni, “Lycopene Inhibition of Cell Cycle Progression in Breast and Endometrial Cancer Cells Is Associated with Reduction in Cyclin D Levels and Retention of p27 (Kip1) in the Cyclin E-cdk2 Complex,” Oncogene, Vol. 20, No. 26, 2001, pp. 3428-3436. doi:10.1038/sj.onc.1204452

[4]   J. Karppi, S. Kurl, T. Nurmi, T. H. Rissanen, E. Pukkala and K. Nyyssonen, “Serum Lycopene and the Risk of Cancer: The Kuopio Ischaemic Heart Disease Risk Factor (KIHD) Study,” Annals of Epidemiology, Vol. 19, No. 7, 2009, pp. 512-518. doi:10.1016/j.annepidem.2009.03.017

[5]   K. Wertz, U. Siler and R. Goralczyk, “Lycopene: Modes of Action to Promote Prostate Health,” Archives of Biochemistry and Biophysics, Vol. 430, No. 1, 2004, pp. 127134. doi:10.1016/

[6]   O. Aust, N. Ale-Agha, L. Zhang, H. Wollersen, H. Sies and W. Stahl, “Lycopene Oxidation Product Enhances Gap Junctional Communication,” Food and Chemical Toxicology, Vol. 41, No. 10, 2003, pp. 1399-1407. doi:10.1016/S0278-6915(03)00148-0

[7]   C. M. Rick, J. W. Uhlig and A. D. Jones, “High Alphatomatine Content in Ripe Fruit of Andean Lycopersicon Esculentum var. Cerasiforme: Developmental and Genetic Aspects,” Proceeding of the National Academy of Sciences USA, Vol. 91, No. 26, 1994, pp. 12877-12881. doi:10.1073/pnas.91.26.12877

[8]   M. Friedman and G. M. McDonald, “Potato Glycoalkaloids: Chemistry, Analysis, Safety and Plant Physiology,” Critical Review in Plant Sciences, Vol. 16, No. 1, 1997, pp. 55-132.

[9]   C. A. Ryan and G. Pearce, “Systemins: A Functionally Defined Family of Peptide Signals That Regulate Defensive Genes in Solanaceae Species,” Proceeding of the National Academy of Sciences USA, Vol. 100, No. 2, 2003, pp. 14577-14580.

[10]   J. Stratmann, J. Scheer and C. A. Ryan, “Suramin Inhibits Initiation of Defense Signaling by Systemin, Chitosan, and a Beta-Glucan Elicitor in Suspension-Cultured Lycopersicon peruvianum Cells,” Proceedings of the National Academy of Sciences USA, Vol. 97, No. 16, 2000, pp. 8862-8867. doi:10.1073/pnas.97.16.8862

[11]   T. Mosmann, “Rapid Colorimetric Assay for Cellular Growth and Survival: Application to Proliferation and Cytotoxic Assays,” Journal of Immunological Methods, Vol. 65, No. 1-2, 1983, pp. 55-63. doi:10.1016/0022-1759(83)90303-4

[12]   C. A. Ryan, “The Systemin Signaling Pathway: Differential Activation of Plant Defensive Genes,” Biochimica et Biophysica Acta, Vol. 1477, No. 1-2, 2000, pp. 112-121. doi:10.1016/S0167-4838(99)00269-1

[13]   B. McGurl and C. A. Ryan, “The Organization of the Prosystemin Gene,” Plant Molecular Biology, Vol. 20, No. 3, 1992, pp. 405-409. doi:10.1007/BF00040600