OJVM  Vol.3 No.2 , June 2013
Genital and Extragenital Canine Transmissible Venereal Tumor in Dogs in Grenada, West Indies
Abstract: Transmissible venereal tumor (TVT) is a widely reported transplantable tumor in dogs, with no breed or sex predilection and with a low metastatic rate. This retrospective study conducted from 2005 and 2011 sought to evaluate the total number of TVT cases, and to report extragenital TVT lesions in dogs from the small tropical island of Grenada, West Indies. Evaluation of the biopsy and necropsy specimens from dogs with TVT was carried out by cytological and histopathological methods. In the present study, we observed a total of 78 dogs with TVT, comprising 40 male and 38 female dogs. Most cases were from dogs between 3 and 6 years; less frequently from older dogs (over 6 years) or younger dogs (1 - 2 years of age). In the present study, we report 15 cases (19.2%) of dogs with TVT in extragenital sites. Tumors were noted in the nasal cavity, eye orbit, spleen, liver, skin, ribs, subcutaneous, and submandibular, cervical and inguinal lymph nodes. There was also evidence of metastasis to the ovaries in 2 dogs. The most interesting finding was the presence of extragenital lesions without primary genital involvement in 4 cases (5.1%). Our findings emphasize the need to consider TVT on the list of differential diagnosis for masses in extragenital sites in dogs from geographic regions where TVT is prevalent.
Cite this paper: A. Chikweto, S. Kumthekar, H. Larkin, C. Deallie, K. Tiwari, R. Sharma and M. Bhaiyat, "Genital and Extragenital Canine Transmissible Venereal Tumor in Dogs in Grenada, West Indies," Open Journal of Veterinary Medicine, Vol. 3 No. 2, 2013, pp. 111-114. doi: 10.4236/ojvm.2013.32018.

[1]   F. Albanese, A. Poli, F. Millanta and F. Abramo, “Primary Cutaneous Extragenital Canine Transmissible Venereal Tumour with Leishmania-Laden Neoplastic Cells: A Further Suggestion of Histiocytic Origin?” Veterinary Dermatology, Vol. 13, No. 5, 2002, pp. 243-246.

[2]   R. A. Foster, “Female and Male Reproductive Systems,” In: M. D. McGavin and J. F. James Zachary, Eds., Pathologic Basis of Veterinary Disease, 4th Edition, Mosby, St. Louis, 2007, pp. 1306,1346.

[3]   A. Gurel, B. Kuscu, E. G. Gulanber and S. S. Arun, “Transmissible Venereal Tumors Detected in the Extragenital Organs of Dogs,” Israel Journal of Veterinary Medicine, Vol. 57, No. 2, 2002, pp. 1-8.

[4]   K. S. Rogers, M. A. Walker and H. B. Dillon, “Transmissible Venereal Tumor: A Retrospective Study of 29 Cases,” Journal of the American Animal Hospital Association, Vol. 34, 1998, pp. 463-470.

[5]   A. Bastan, B. Duygu and C. Mehmet, “Uterine and Ovarian Metastasis of Transmissible Venereal Tumor in a Bitch,” Turkish Journal of Veterinary and Animal Sciences, Vol. 32, No. 1, 2008, pp. 65-66.

[6]   L. N. Chiti, K. Too and P. D. Sayer, “Anal Transmissible Tumor in a Dog,” Zambian Journal of Veterinary Science, Vol. 1, No. 1, 1996, pp. 23-26.

[7]   U. Das and K. Das, “Review of Canine Transmissible Venereal Sarcoma,” Veterinary Research Communications, Vol. 24, No. 8, 2000, pp. 545-556. doi:10.1023/A:1006491918910

[8]   M. Park, Y. Kim, M. Knag, S. Oh, D. Cho, N. Shin and D. Kim, “Disseminated Transmissible Venereal Tumor in a Dog,” Journal of Veterinary Diagnostic Investigation, Vol. 18, No. 1, 2006, pp. 130-133. doi:10.1177/104063870601800123

[9]   J. H. Rust, “Transmissible Lymphosarcoma in the Dog,” Journal of the American Veterinary Medical Association, Vol. 114, No. 862, 1949, pp. 10-14.

[10]   D. A. Higgins, “Observations on the Canine Transmissible Venereal Tumor as Seen in the Bahamas,” Veterinary Record, Vol. 79, No. 3, 1966, pp. 67-71. doi:10.1136/vr.79.3.67

[11]   O. O. Oduye, B. O. Ikede, G. O. Esuruoso and J. U. Akpokodje, “Metastatic Transmissible Venereal Tumour in Dogs,” Journal of Small Animal Practice, Vol. 14, No. 10, 1973, pp. 625-637. doi:10.1111/j.1748-5827.1973.tb06399.x

[12]   B. Ivoghli, “Canine Transmissible Venereal Tumor in Iran,” Veterinary Pathology, Vol. 14, 1977, pp. 289-290. doi:10.1177/030098587701400313

[13]   A. J. Ferreira, A. Jaggy, A. P. Varejao, M. L. Ferreira, J. M. Correia, J. M. Mulas, O. Almeida, P. Oliveira and J. Prada, “Brain and Ocular Metastases from a Transmissible Venereal Tumor in a Dog,” Journal of Small Animal Practice, Vol. 41, No. 4, 2000, pp. 165-168. doi:10.1111/j.1748-5827.2000.tb03187.x

[14]   T. O. Abuom and J. D. Mande, “Transmissible Venereal Tumor with Subcutaneous and Bone Metastasis,” The Kenya Veterinarian, Vol. 30, No. 1, 2006, pp. 10-12.

[15]   S. Mukaratirwa and E. Gruys, “Canine Transmissible Venereal Tumor: Cytogenetic Origin, Immunophenotype, and Immunobiology: A Review,” Veterinary Quarterly, Vol. 25, No. 3, 2003, pp. 101-111. doi:10.1080/01652176.2003.9695151

[16]   L. G. Papazoglou, A. F. Koutinas, A. G. Plevraki and D. Tontis, “Primary Intranasal Transmissible Venereal Tumor in the Dog: A Retrospective Study of Six Spontaneous Cases,” Journal of Veterinary Medicine Series A—Physiology Pathology Clinical Medicine, Vol. 48, No. 7, 2001, pp. 391-400.

[17]   K. Gupta and N. K. Sood, “Pathological and Immunohistochemical Studies on Rare Cases of Primary Extra-Genital Transmissible Venereal Tumours in the Mammary Gland,” Veterinarni Medicina, Vol. 57, No. 4, 2012, pp. 198-206.

[18]   P. C. Kennedy and R. B. Miller, “Female Genital System,” In: K. V. F. Jubb, P. C. Kennedy, P. N. Nigel, Eds., Pathology of Domestic Animals, 4th Edition, Academic Press, New York, 1993, pp. 451-453.