Dual-energy X-ray absorptiometry (DXA) is an
attractive method for evaluating sarcopenia, age-related
loss of skeletal muscle mass and function, using
appendicular lean tissue (aLT) mass for criteria of diagnosis, although minimal
radiation is exposed. Skeletal muscle (SM) mass can be
estimated by using ultrasound-measured muscle thickness (MTH). However, the
association between these two methods is unclear. To examine the relationship
between DXA-derived aLT mass and total body SM mass estimated by ultrasound,
thirty-six healthy adults (18 men and 18 women) aged 19 - 65 years
participated in this study. Ultrasound-measured muscle thickness was used to
estimate the total SM mass. DXA was used to estimate whole body and regional
body composition, and aLT mass was considered equivalent to the sum of lean
tissue in both the right and left arms and legs. Total
SM mass (26.3 ± 4.4 kg for
men and 15.7 ± 2.6 kg for
women) estimated by ultrasound was similar to DXA-estimated aLT mass (24.5 ± 3.8 kg for men and 15.7 ± 2.7 kg for women). There was a strong
correlation between DXA-measured aLT mass and total SM mass estimated by
ultrasound in men (r = 0.927, n = 18) and women (r = 0.931, n = 18) as well as
overall sample (r = 0.975, n = 36). The ratio of total SM mass to aLT mass was
1.07 for men and 1.00 for women. These results suggest that DXA-derived aLT
mass can be accurately predicted from ultrasound estimated total SM mass,
although the predicted value may underestimate in men (approximately 7% at the
Cite this paper
T. Abe, N. Dabbs, V. Nahar, M. Ford, M. Bass and M. Loftin, "Relationship between Dual-Energy X-Ray Absorptiometry-Derived Appendicular Lean Tissue Mass and Total Body Skeletal Muscle Mass Estimated by Ultrasound," International Journal of Clinical Medicine, Vol. 4 No. 6, 2013, pp. 283-286. doi: 10.4236/ijcm.2013.46049.
 R. N. Baumgartner, K. M. Koehler, D. Gallagher, L. Romero, S. B. Heymsfield, R. Ross, P. J. Garry and R. D. Linderman, “Epidemiology of Sarcopenia among the Elderly in New Mexico,” American Journal of Epidemiology, Vol. 147, No. 8, 1998, pp. 755-763.
 A. Y. Bijlsma, C. G. Meskers, C. H. Ling, M. Narici, S. E. Kurrle, I. D. Cameron, R. G. Westendrorp and A. B. Maier, “Defining Sarcopenia: The Impact of Different Diagnostic Criteria on the Prevalence of Sarcopenia in a Large Middle Aged Cohort,” Age, Vol. 35, No. 3, 2013, pp. 871-881. doi:10.1007/s11357-012-9384-z
 I Janssen, S. B. Heymsfield, R. N. Baumgartner and R. Ross, “Estimation of Skeletal Muscle Mass by Bioelectrical Impedance Analysis,” Journal of Applied Physiology, Vol. 89, No. 2, 2000, pp. 465-471.
 K. Sanada, C. F. Kearns, T. Midorikawa and T. Abe, “Prediction and Validation of Total and Regional Skeletal Muscle Mass by Ultrasound in Japanese Adults,” European Journal of Applied Physiology, Vol. 96, No. 1, 2006, pp. 24-31. doi:10.1007/s00421-005-0061-0
 T. Midorikawa, K. Sanada, A. Yoshitomi and T. Abe, “Is the Use of Ultrasound-Derived Prediction Equations for Adults Useful for Estimating Total and Regional Skeletal Muscle Mass in Japanese Children?” British Journal of Nutrition, Vol. 101, No. 1, 2009, pp. 72-78.
 J. Kim, Z. Wang, S. B. Heymsfield, R. N. Baumgartner and D. Gallagher, “Total-Body Skeletal Muscle Mass: Estimation by a New Dual-Energy X-Ray Absorptiometry Method,” American Journal of Clinical Nutrition, Vol. 76, No. 2, 2002, pp. 378-383.
 J. Kim, W. Shen, D. Gallagher, A. Jones Jr, Z. Wang, J. Wang, S. Heshka and S. B. Heymsfield, “Total-Body Skeletal Muscle Mass: Estimation by Dual-Energy X-Ray Absorptiometry in Children and Adolescents,” American Journal of Clinical Nutrition, Vol. 84, No. 5, 2006, pp. 1014-1020.
 T. Abe, M. Kondo, Y. Kawakami and T. Fukunaga, “Prediction Equations for Body Composition of Japanese Adults by B-Mode Ultrasound,” American Journal of Human Biology, Vol. 6, No. 2, 1994, pp. 161-170.
 T. Abe and T. Fukunaga, “Relationship between Subcutaneous Fat and Muscle Distributions and Serum HDLCholesterol,” Journal of Atherosclerosis and Thrombosis, Vol. 1, No. 1, 1994, pp. 15-22.
 J. M. Bland and D. G. Altman, “Statistical Methods for Assessing Agreement between Two Methods of Clinical Measurement,” Lancet, Vol. 8, No. 1, 1986, pp. 307-310.
 T. Abe, C. F. Kearns and T. Fukunaga, “Sex Differences in Whole Body Skeletal Muscle Mass Measured by Magnetic Resonance Imaging and Its Distribution in Young Japanese Adults,” British Journal of Sports Medicine, Vol. 37, No. 5, 2003, pp. 436-440. doi:10.1136/bjsm.37.5.436
 T. Abe, R. S. Thiebaud, J. P. Loenneke, M. G. Bemben, M. Loftin and T. Fukunaga, “Influence of Severe Sarcopenia in Cardiovascular Risk Factors in Nonobese Men,” Metabolic Syndrome and Related Disorders, Vol. 10, No. 6, 2012, pp. 407-412. doi:10.1089/met.2012.0057
 T. W. Buford, D. J. Lott, E. Marzetti, S. E. Wohlgemuth, K. Vandenborne, M. Pahor, C. Leeuwenburgh and T. M. Manini, “Age-Related Differences in Lower Extremity Tissue Compartments and Associations with Physical Function in Older Adults,” Experimental Gerontology, Vol. 47, No. 1, 2012, pp. 38-44. doi:10.1016/j.exger.2011.10.001