The purpose of this study was to compare among
dysplasia of oral, uterine cervix and bronchus. Using a computer
cytomorphometry cell measurement program, the study was based on a
retrospective review of smear cases diagnosed with dysplasia of oral, bronchial
and uterine cervix, from 2002 to 2010. For 50 - 70 cells from each lesion,
nuclear (N) and cytoplasm (C) variables were assessed: area (A), diameter (D),
irregularity (I), stain brightness and granularity. NA and ND were highest in
OSCC and higher according to dysplastic grading. By contrast, CA and CD were lowest
in severe dysplasia. The significant difference of N/C ratio was observed among
OSCC to inflammation, mild and moderate dysplasias (p < 0.05). The N/C
ratios of mild and moderate dysplasias were equal. Brightness and granularity
values of OSCC cases were significantly higher than those of another (p < 0.05).
About the difference between mild to moderate dysplasias, it was the easiest
to detect of the uterine cervix. All severe dysplasias among the 3 regions
were easily identified morphometrically. The deficient in the difference
between inflammation to mild dysplasia and mild to moderate dysplasia were
obtained in the oral mucosal lesion. The results displayed a significant
variation in cytomorphometrical values among the 3 regions. N/C values for
uterine cervix and bronchus were well distinguished in comparison with oral
dysplasias. Screening of mild and moderate dysplasias requires experience which
carries out the comprehensive judgment of the color.
Cite this paper
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