ABSTRACT Identification and analysis of tissue-specific
(TS) genes and their regulatory activities
play an important role in understanding the mechanisms of the organism, disease
diagnosis and drug design. Although so far we are not clear about the
mechanisms totally, the sequence features
of TS genes are becoming an important clue. In this paper we used an
integrated pipeline to discover sequences motifs for the promoter
regions of TS genes. To test the significances of those motifs in a specific tissue, we used hypotheses test approaches
including Bayesian hypothesis, Binomial distribution and traditional z-test. We finally got 2784, 1204 and 703 motifs respectively out of 3244 motifs
obtained in discovery phase using above three tests from 3954 TS genes across 83 human tissues. 52.7% of those motifs can be found in public databases available.
Cite this paper
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