Introduction: Chronic sinusitis affects all age groups and is a cause for significant morbidity. Recent realization that noninfectious inflammatory causes can predispose to infectious sinusitis has evoked renewed interest in developing and documenting efficacious ancillary therapies that could supplement antibiotic use. Hypertonic saline solution has been shown to increase mucociliary clearance and ciliary beat frequency. Objectives: A double blinded randomized comparative study was undertaken to evaluate the effect of hypertonic saline (3.5%) nasal drops and normal saline (0.9%) nasal drops, to assess the tolerance of hypertonic saline nasal drops and to know if hypertonic nasal drops improve the “quality of life” in patients with chronic sinusitis. Methods: Fifty patients diagnosed as chronic sinusitis in the age group of 18-45 years were randomized into two groups; Group A was treated with normal saline and Group B with 3.5% hypertonic saline for a period of 4 weeks. Pre and Post treatment x-rays of the paranasal sinuses (Water’s view) were graded and radiological scores were given accordingly. The symptoms were evaluated before and after treatment using visual analogue score. Patients were queried about tolerance to the nasal solution and scores were given. Conclusion: Hypertonic saline nasal solution is more efficacious than normal saline solution in the treatment of patients with chronic sinusitis. Hypertonic saline nasal solution was well tolerated and it improved quality of life in these patients.
 O. Berg, H. Bergstedt, C. Carenfelt and M. G. Zind, “Discrimination of purulent from non-purulent maxillary sinusitis: Clinical and radiographic diagnosis,” The Annals of Otology, Rhinology, and Laryngology, Vol. 90, No. 3, 1981, pp. 272-275.
 D. Shoseyov, H. Bibi, P. Shai, N. Shoseyov, G. Shazberg and H. Hurvitz, “Treatment with Hypertonic Saline versus Normal Saline Nasal Wash of Pediatric Chronic Sinusitis,” Journal of Allergy and Clinical Immunology, Vol. 101, No. 5, 1998, pp. 602-605. doi:10.1016/S0091-6749(98)70166-6
 “Instruction Manual and General Information on Yogic Saline Nasal Cleansing Technique. The Jala-neti Booklet,” 2005. http://www.yogaage.com/asanas/jala.pdf
 Y. Majima, Y. Sakakura, T. Matsubara, S. Murai and Y. Miyoshi, “Mucociliary Clearance in Chronic Sinusitis: Related Human Nasal Clearance and in Vitro Bullfrog Palate Clearance,” Biorheology, Vol. 20, No. 2, 1983, pp. 251-262.
 M. J. Dulfano, K. Adler and O. Wooten, “Primary Properties of Sputum. IV. Effects of 100 Percent Humidity and Water Mist,” American Review of Respiratory Disease, Vol. 107, No. 1, 1973, pp. 130-132.
 C. M. Rossman, R. M. Lee, J. B. Forrest and M. T. Newhouse, “Nasal Ciliary Ultrastructure and Function in Patients with Primary Ciliary Dyskinesia Compared with That in Normal Subjects and in Subjects with Various Respiratory Diseases,” American Review of Respiratory Disease, Vol. 129, No. 1, 1984, pp. 161-170.
 H. G. Folkesson, F. Kheradmand and M. A. Matthay, “The Effect of Salt Water on Alveolar Epithelial Barrier Function,” American Journal of Respiratory and Critical Care Medicine, Vol. 150, No. 6, 1994, pp. 1555-1563. doi:10.1164/ajrccm.150.6.7952614
 N. T. Johnson, M. Villalon, F. H. Royce, R. Hard, P. Verdugo, “Autoregulation of Beat Frequency in Respiratory Ciliated Cells. Demonstrated by Viscous Loading,” American Review of Respiratory Disease, Vol. 144, No. 5, 1991, pp. 1091-1094. doi:10.1164/ajrccm/144.5.1091
 L. T. Tomooka, “Claire Murphy and Terence M Davidson. Clinical Study and Literature Review of Nasal Irrigation,” Laryngoscope, Vol. 110, No. 7, 2000, pp. 1189-1193. doi:10.1097/00005537-200007000-00023
 D. G. Heatley, K. E. McConnell, T. L. Kille and G. E. Leverson, “Nasal Irrigation for the Alleviation of Sinonasal Symptoms,” Otolaryngology—Head and Neck Surgery, Vol. 125, No. 1, 2001, pp. 44-48. doi:10.1067/mhn.2001.115909
 D. Rabago, A. Zgierska, M. Mundt, B. Barrett, J. Bobula and R. Maberry, “Efficacy of Daily Hypertonic Saline Nasal Irrigation among Patients with Sinusitis,” The Journal of Family Practice, Vol. 51, No. 12, 2002, pp. 1049-1055.